Development of new diagnostic and of cognitive dysfunction using saliva by metabolome analysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20566
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: To Masahiro 神奈川歯科大学, 大学院歯学研究科, 助教 (70707348)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 唾液 / 認知症 / メタボローム

Outline of Final Research Achievements

In this study, to clarify the relationship between the pathology of cognitive dysfunction and the change of saliva components in dementia patients, we aimed to develop a new diagnostic and evaluation method of cognitive dysfunction using saliva by metabolome analysis. We conducted experiments on animals and human subjects, and revealed the changes in saliva components by cognitive dysfunction using metabolome analysis. These findings indicate relation to saliva component and cognitive function, and it was possible to study of saliva test.

Free Research Field

口腔科学