2016 Fiscal Year Final Research Report
Application to root resorption prevention and elucidation of periodontal tissue metabolic activity mechanism by drug discovery using amelogenin peptide and Platelet Rich Plasma
| Project/Area Number |
15K20593
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Yoshimi Yuki 広島大学, 病院(歯), 病院助教 (50707081)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | アメロゲニン / 歯根吸収 |
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| Outline of Final Research Achievements |
In this study, we focused on functional amelogenin peptides and PRP which is considered effective for wound healing. We clarified the influence of these on the metabolic regulation mechanism of periodontal tissues and studied as the ultimate goal of establishing the root absorption prevention method using these.It was suggested that the combination of functional amelogenin peptide and PRP is effective for cell activity of cementoblasts. Root absorption is a condition caused by excessive absorption of cementum. This study suggested the possibility of developing a novel root absorption prevention method using functional amelogenin peptide which improves the cell activity of cementoblasts.
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| Free Research Field |
歯科矯正学
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