2017 Fiscal Year Final Research Report
Investigating the influence of epigenetic regulation on feeding behavior
Project/Area Number |
15K20611
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | Nihon University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 摂食行動 / エピジェティクス / MeCP2 / Rett 症候群 / 視床下部 / ノルアドレナリン / コレシストキニン / 代謝 |
Outline of Final Research Achievements |
It was suggested that the effect of suppressing feeding behavior by cholecystokinin administration was decreased in female heterozygous MeCP2-deficient mice. From this result, it is considered that neurotransmission from the periphery may be decreased due to MeCP2 deficiency. This study suggests that feeding behavior changes with epigenetic regulation. We also believe that diminished capacity for signal transduction from the peripheral nerves may cause various symptoms in Rett syndrome cases. We believe that the results of this study are meaningful in terms of promote understanding of the pathology of Rett syndrome and epigenetic regulation abnormality.
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Free Research Field |
小児歯科学
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