2016 Fiscal Year Final Research Report
Identification of a role of apelin in obesity and periodontitis patients
| Project/Area Number |
15K20625
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
|
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| Research Collaborator |
Nakashima Keisuke
Usui Michihiko
Morishita Masaki
Nakamichi Ikuo
Muraoka Kousuke
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | apelin / GCF / adipokine / cytokine |
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| Outline of Final Research Achievements |
In serum, apelin level were lower in periodontitis group and obesity/periodontitis group than in non-periodontitis group. In gingival crevicular fluid (GCF), apelin level were lower in obesity group and obesity/periodontitis group than non-periodontitis group. Furthermore, pretreatment with apelin decreased Porphyromonas gingivalis LPS-induced expression of inflammatory cytokines in J774.1 cells.
These observations suggest that reduction of apelin level of GCF in obesity patients aggravates periodontitis.
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| Free Research Field |
医歯薬学
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