2016 Fiscal Year Final Research Report
A role of amelotin in apoptosis and epithelial-mesenchymal transition of gingival junctional epithelium
| Project/Area Number |
15K20630
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Periodontology
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 歯肉接合上皮 / アメロチン / アポトーシス / 慢性歯周炎 |
|---|
| Outline of Final Research Achievements |
Amelotin (AMTN) is an enamel protein that localized at gingival junctional epithelium (JE), however its function remain unclear. It's important for the understanding of biological response against periodontitis to evaluate homeostasis and pathology of JE. In this study, we examined the change of AMTN gene expression in gingival epithelium induced apoptosis, and observed AMTN localization at JE in Smad3 knockout mice. AMTN mRNA levels were temporally increased at TGFβ1-induced apoptosis of gingival epithelium. Smad3 was mediated in the transcriptional upregulation. Thus, AMTN might play a role in apoptosis of gingival epithelium.
|
| Free Research Field |
歯周病学
|
