Circumspect Management of Oral Conditions in the Medically Compromised Patients at Perioperative Period

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20655
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Tsurumi University
• Principal Investigator: Okada Ayako 鶴見大学, 歯学部, 学部助手 (60515584)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 易感染性宿主 / 口腔ケア / 次亜塩素酸電解水 / 細胞毒性 / 細胞間接着分子 / 感染制御

Outline of Final Research Achievements

Medically compromised patients, especially at perioperative conditions are prone to a range of oral complications majorly due to the loss of mucosal integrity. Proper preventive management would minimize the risks of oral and associated systemic complications. In recent years, electrolyzed saline solutions are gaining interests for their anti-bacterial potentials in shortest possible application time. In this study, some reactive oxygen species based electrolyzed saline solutions known as super-oxidized water (SOW) containing hypochlorous acid have been examined for their cytotoxicity. Results have indicated that a highly purified SOW containing 125 mg/L active chlorine concentrations with pH of 6.8 might be safe for useful in management of oral conditions at perioperative period especially for the medically compromised patients as it showed very low level of cytotoxicity on HeLa mucosal epithelial cells.

Free Research Field

予防歯科