To detect the affects of maternal exposure of OH-PCBs during pregnancy on metabolic pathway and disruption of reproductive hormones

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20825
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine; Hygiene and public health
• Research Institution: Hokkaido University
• Principal Investigator: Sachiko ITOH (伊藤佐智子) 北海道大学, 環境健康科学研究教育センター, 特任講師 (90580936)
• Project Period (FY): 2015-03-01 – 2018-03-31
• Keywords: OH-PCB / 性ホルモン / 胎児期曝露 / 出生コホート / 一塩基多型

Outline of Final Research Achievements

Evidence on the toxicity of hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) for reproductive hormones is limited. In addition,there was no statistical difference between any of the Single Nucleotide Polymorphism（SNPs） related to metabolic pathway and OH-PCB concentrations in maternal blood during pregnancy. We aimed to investigate the effects of environmental prenatal exposure to OH-PCBs and reproductive hormone levels in cord blood, taking into account the maternal SNPs into account.169 mother-infant pairs registered to Sapporo cohort, the Hokkaido Study, were included in this analysis. In multiple linear regression models, significant inverse associations were found between maternal 4-OH-CB146+3-OH-CB153 and boy's sex hormone biding globulin (SHBG) in dose-response manner.Maternal 4-OH-CB187 level was associated with decreased girl's progesterone.There was no significant difference of OH-PCB levels or effect on hormones between each type of SNPs.

Free Research Field

公衆衛生学