2016 Fiscal Year Final Research Report
The analysis of pathogenic CD4+ T cells in mice model of Sjogren's syndrome
| Project/Area Number |
15K20882
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
Pathobiological dentistry/Dental radiology
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| Research Institution | Keio University (2016)
University of Tsukuba (2015) |
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Principal Investigator |
Iizuka Mana (飯塚麻菜) 慶應義塾大学, 医学部(信濃町), 特任助教 (80734821)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 自己免疫疾患 |
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| Outline of Final Research Achievements |
To reveal the pathological role of CD4+ T cells, we used RORγt Tg mice, which have been found to spontaneously develop severe sialadenitis-like Sjogren's syndrome (SS). Our results demonstrated that both RORγt-overexpressed CD4+ T cells and reduced Treg cells via suppression of IL-2 induced phosphorylation of STAT5 might contribute to the development of SS-like sialadeitis. This research was reported by the journal of "The Journal of Immunology".
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| Free Research Field |
免疫学
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