2016 Fiscal Year Final Research Report
Analyses of a mechanism and physiological significance of NSD.
| Project/Area Number |
15K20947
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Molecular biology
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | NSD / NMD / RNAi |
|---|
| Outline of Final Research Achievements |
Nonstop mRNA decay (NSD) is a mechanism that immediately degrades aberrant mRNAs lacking stop codon. In this study, we attempted to reveal a mechanism of NSD in higher eukaryote and endogenous targets of NSD.
As a result, we revealed pivotal factors of NSD in higher eukaryote. Furthermore, we identified mRNA intermediates produced in other mRNA degrading mechanisms as endogenous NSD targets. These results indicate that NSD is generally required to eliminate mRNA intermediates produced in other mRNA degrading mechanisms.
|
| Free Research Field |
分子生物学
|
