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2016 Fiscal Year Final Research Report

Analyses of a mechanism and physiological significance of NSD.

Research Project

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Project/Area Number 15K20947
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Molecular biology
Neurochemistry/Neuropharmacology
Research InstitutionThe University of Tokyo

Principal Investigator

Hashimoto Yoshifumi  東京大学, 医科学研究所, 特任研究員 (80734540)

Project Period (FY) 2015-04-01 – 2017-03-31
KeywordsNSD / NMD / RNAi
Outline of Final Research Achievements

Nonstop mRNA decay (NSD) is a mechanism that immediately degrades aberrant mRNAs lacking stop codon. In this study, we attempted to reveal a mechanism of NSD in higher eukaryote and endogenous targets of NSD.
As a result, we revealed pivotal factors of NSD in higher eukaryote. Furthermore, we identified mRNA intermediates produced in other mRNA degrading mechanisms as endogenous NSD targets. These results indicate that NSD is generally required to eliminate mRNA intermediates produced in other mRNA degrading mechanisms.

Free Research Field

分子生物学

URL: 

Published: 2018-03-22  

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