Elucidation of the role of oxygen-dependent dioxygenases on the development of tumor microenvironments

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20970
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology; Pathological medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Tabu Kouichi 東京医科歯科大学, 難治疾患研究所, 助教 (10466469)
• Research Collaborator: TAGA Tetsuya 東京医科歯科大学, 難治疾患研究所, 教授 (40192629) ; KIMURA Taichi 北海道大学, 医学研究科, 特任助教 (90435959)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 癌 / 微小環境 / マクロファージ / 鉄 / ストレス応答

Outline of Final Research Achievements

This study has been carried out with the aim of elucidating the mechanisms how tumor microenvironments are developed during tumor progression. We have revealed that a subpopulation of glioma cells induces macrophages expressing iron-recycling genes　under the iron-deficient stress, which suggests that stress response by tumor cells plays important roles in the development of tumor microenvironments. We also found that the induction of macrophages is potentially mediated by the epigenetic upregulation of CCL2 and GMCSF genes　in tumor cells. Our findings could help establish new strategies for cancer therapy targeting microenvironments.

Free Research Field

腫瘍生物学