The role of cortico-hippocampal interaction for systems consolidation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21013
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience; Basic / Social brain science
• Research Institution: Tokyo University of Science (2016); University of Toyama (2015)
• Principal Investigator: Sano Yoshitake 東京理科大学, 理工学部応用生物科学科, 助教 (90415175)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 記憶 / 大脳皮質 / 海馬 / Systems consolidation / エングラム

Outline of Final Research Achievements

We addressed the mechanism for systems consolidation and especially tested the hypothesis that “cortico-hippocampal co-activation following learning has an impact on systems consolidation”. To address this hypothesis, we developed the systems labeling and manipulating cell assembly activated during learning. Then, cortico-hippocampal neurons activated during learning were co-stimulated during sleep after learning. We observed mice tended to show that memory generalization was enhanced and hippocampal-dependency for memory retrieval was decreased. But to confirm these results, we have to improve methods for activating cell assembly.

Free Research Field

神経科学