Mechanical properties of the irradiated bone

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21016
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery; Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: Kato Satoshi 金沢大学, 附属病院, 助教 (30584841)
• Research Collaborator: TSUCHIYA Hiroyuki ; MURAKAMI Hideki ; IGARASHI Takashi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脊椎 / 骨強度 / 放射線照射 / 骨質

Outline of Final Research Achievements

To examine the fragility of irradiated vertebral bone, we performed a mechanical stress tests and structure analysis by μCT on irradiated rat vertebrae. Rats received a single external irradiation of 20 Gy on the lumbar vertebra using a small animal irradiation apparatus. After irradiation, they were sacrificed the irradiated vertebrae were excised. We performed the vertebral body compression load test and μCT analyses of the vertebrae. Bone strength was significantly lower in the irradiated group than in the non-irradiated group. In μCT analyses, reduced trabecular connectivity were observed in the irradiated group as compared with the non-irradiated group. The three-dimensional structure was coarse in the irradiated group. However, bone mineral densities of the 2 group were almost the same. The results of this study indivated that the microstructure changes of cancellous bone in the radiated vertebrae led to a decrease in bone strength without a change in bone density.

Free Research Field

脊椎脊髄外科