2016 Fiscal Year Final Research Report
Investigation of the pathophysiology and developmento of treatment for secondary lymphedema.
| Project/Area Number |
15K21052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
Cardiovascular surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Sano Masaki 浜松医科大学, 医学部附属病院, 診療助教 (40733514)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 二次性リンパ浮腫 / エイコサペンタエン酸 / 皮膚線維化 / 筋線維芽細胞 |
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| Outline of Final Research Achievements |
We developed a rat model of secondary lymphedema.Our model showed increase of limb volume, accumulation of lymphatic fluid, increase of collagen and skin hardness. Our lymphedma model mimic to human lymphedema patients, Using our model, we showed myofibroblasts exist in skin tissues of lymphedema model and accelerate collagen synthesis to result in fibrosis. Moreover, eicosapentaenoic acid (EPA) prevent skin fibrosis in vitro study. Similar findings were observed in skin samples from lymphedema patients. EPA may be useful in inhibiting fibrosis in patients with secondary lymphedema.
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| Free Research Field |
リンパ浮腫
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