Screening of ECM-selective peptide for Small-diameter artificial blood vessels

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21070
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biofunction/Bioprocess; Biomedical engineering/Biomaterial science and engineering
• Research Institution: Nagoya University
• Principal Investigator: Kanie Kei 名古屋大学, 創薬科学研究科, 助教 (80636407)
• Research Collaborator: KATO Ryuji 名古屋大学, 大学院創薬科学研究科, 准教授 ; EBARA Mitsuhiro 物質・材料研究機構, MANAナノシステム分野, MANA准主任研究者
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ペプチド / 人工血管 / バイオマテリアル / 内皮細胞 / 高分子材料 / コラーゲンIV / 間葉系幹細胞 / 骨再生

Outline of Final Research Achievements

Aim of this study is obtaining short selective-peptides for enhancing the effect of artificial blood vessel. There are two detail aims, one is screening ECM-selective adhesion peptides, and another is screening endotherial cell(EC)-selective adhesion peptides. As a result, some Collagen IV-selective peptides and EC-selective peptides were successfully obtained in this two years. Additionally, combination of peptide and polymeric materials could control the EC-selectivity.

Free Research Field

生物化学工学