2016 Fiscal Year Final Research Report
Synthesis of gamma-glutamyl transpeptidase-specific chemical probes and their application to cancer immunotherapy
| Project/Area Number |
15K21117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
Biomolecular chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | γ-グルタミルトランスペプチダーゼ / GGT / 酵素阻害剤 / GGsTop / 分子プローブ / 抗体依存性細胞傷害 |
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| Outline of Final Research Achievements |
Four novel chemical probes based on the structure of GGsTop, a potent and selective γ-glutamyl transpeptidase (GGT) inhibitor, were designed and synthesized. One of theses probes inhibited human GGT strongly. These results opened the gate to the development of novel ligands that could exert antibody-dependent cellular cytotoxicity against various cancer cells overexpressing GGT on their cell surfaces.
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| Free Research Field |
有機合成化学、生物有機化学
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