2016 Fiscal Year Final Research Report
Mechanism of tumor rebound after discontinuation of anti-VEGF treatment
| Project/Area Number |
15K21205
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
Tumor biology
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| Research Institution | Iwate University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 血管新生 / 分子標的薬 |
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| Outline of Final Research Achievements |
Mouse mammary tumor cell line 4T1 cell were used. BALB/c mice were injected with 4T1 cells and divided into 4 groups (group A: base line control, group B: 7-days treatment with sunitinib (40 mg/kg, QD), group C: 7-days treatment with sunitinib plus 7-days withdraw, group D: 7-days treatment with vehicle plus 7-days withdraw). Mice were perfused at Day1 (group A), Day7 (group B), and Day14 (group C and D) and analysed by immunohistochemistry. In the group B, a significant decrease of blood vessel density was observed. In the group C, blood vessel density was comparable with group A, that means that decreased blood vessels rapidly recovered after sunitinib withdrawal. The tumor invasiveness to surrounding tissue was much greater in group C than in group B. However, incidence of distant metastasis was comparable between group B and C.
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| Free Research Field |
血管生物学
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