Associations between obesity, abnormal glucose/lipid metabolism, and clinico-biological factors in patients with breast cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21239
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery; Metabolomics
• Research Institution: National Cancer Center Japan
• Principal Investigator: Hayashi Mitsuhiro 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 (50735628)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 乳癌 / 肥満 / 腫瘍硬度 / Elastography / 脂質

Outline of Final Research Achievements

In this study, we investigated the relationship between obesity, abnormal glucose/lipid metabolism, and clinicopathological factors in patients with breast cancer. In postmenopausal estrogen receptor-positive breast cancer, there were many cases with high body mass index. Furthermore, obesity was involved in the tumor stiffness of breast cancer by elastographic evaluation, and tumor stiffness significantly correlated with lymph node metastasis and high gene expression of lysyl oxidase. In vitro/vivo experiments suggested that lipid pathway contributed to the behavior of breast cancer.

Free Research Field

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