Elucidation of regulatory mechanism of capacitation by extracellular Na+ in hamster spermatozoa

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21323
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology; Urology
• Research Institution: Dokkyo Medical University
• Principal Investigator: Takei Gen 獨協医科大学, 医学部, 助教 (00708183)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 哺乳類精子 / 受精能獲得 / 超活性化 / Na+ / Na/K ATPase / Na-Ca Exchanger

Outline of Final Research Achievements

In my previous study, I revealed oviductal fluid contains high concentration of Na+ compared to the medium for the in vitro fertilization in hamsters. Based on the previous study, present study was performed to elucidate the impact of extracellular Na+ on hamster sperm capacitation. The result showed that hyperactivation is regulated by extracellular Na+ in hamster spermatozoa, and the activity of molecules that regulate cellular Na+ homeostasis, such as Na-Ca exchanger or Na/K ATPase, are involved in hamster sperm hyperactivation.

Free Research Field

生殖細胞生理学