2017 Fiscal Year Final Research Report
Development of a novel diagnosis marker for kidney diseases by metabolome analysis
| Project/Area Number |
15K21364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
HIRAYAMA Akiyoshi 慶應義塾大学, 政策・メディア研究科(藤沢), 特任講師 (00572405)
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| Research Collaborator |
MARUYAMA Shoichi
AKIYAMA Shinichi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 腎疾患 / マーカー / CE-MS / 尿 / 血漿 |
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| Outline of Final Research Achievements |
In this study, a comprehensive analysis of urine and plasma metabolites from nephrotic disease patients was conducted by capillary electrophoresis-mass spectrometry (CE-MS) in order to discover biomarkers specific to the type of disease. As a result, it was possible to create a model to distinguish from seven types of nephrotic diseases by combining two to five types of metabolites. With respect to unknown peaks, it was possible to perform a fractionation operation using LC-MS to identify new biomarker candidates.
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| Free Research Field |
メタボロミクス
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