Risk stratification of sudden cardiac death in patients with implantable cardioverter defibrillator using a high resolution electrocardiography; DREAM-ECG

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21388
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering; Medical engineering assessment
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Suzuki Atsushi 東京女子医科大学, 医学部, 助教 (00625626)
• Research Collaborator: SHIGA Tsuyoshi ; NAKAI Kenji
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 突然死 / 心不全 / 12誘導心電図 / 心室不整脈 / 植込み型除細動器 / 心室遅延電位 / 高分解能心電図

Outline of Final Research Achievements

This study included 125 consecutive heart failure (HF) patients received cardiac resynchronization therapy (CRT) with an indication for primary prevention of sudden cardiac death. 6 patients (5%) experienced electrical storm (ES). Patients with ES had a significantly higher Tp-e dispersion on 12-lead ECG (80±27 vs 60±37ms, p<0.05) and inter-lead difference between Tp-e intervals on 187-channel repolarization interval-difference mapping ECG (DREAM-ECG) (84±20 vs 60±23ms, p<0.05) than those without ES. Among 103 consecutive non-ischemic HF patients, 50 (49%) patients had widening filtered QRS (fQRS) between before and after CRT implantation recorded by signal averaged electrocardiograph (SAECG). There was a trend of increased occurrence of ventricular arrhythmias in patients with widening fQRS than narrowing fQRS. In HF patients received CRT, both depolarization and repolarization abnormalities may be associated with the incidence of ventricular arrhythmias after device implantation.

Free Research Field

循環器疾患分野