2017 Fiscal Year Final Research Report
Chemical synthesis of oligonucleotides having keto sugar and their application to chemical biology study
Project/Area Number |
15K21451
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Chemical biology
Biomolecular chemistry
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Research Institution | Kanagawa University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 酸化損傷 / 還元反応 / 細胞内化学反応 / ケト基 |
Outline of Final Research Achievements |
This research aims to explore the unexplored nucleic acid functions and elucidate the biological functions through chemical synthesis of keto sugar type nucleic acid in which the sugar moiety is oxidized. Chemical synthesis of nucleic acids having a keto group at 2 'position was accomplished by incorporating a branched sugar nucleoside as a key precursor. The keto sugar-type nucleic acid showed a different thermal stability compared to DNA (deoxyribose) and RNA (ribose). The introduced keto group could be converted to a hydroxyl group by a reduction reaction in an aqueous solution.
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Free Research Field |
生体関連化学
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