Cerebral radiation necrosis can accelerate tumor regrowth and invasion

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21510
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery; Radiation science
• Research Institution: Osaka Medical College
• Principal Investigator: Hirota Yuki 大阪医科大学, 医学部, 非常勤医師 (80707331)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: グリオーマ / 悪性神経膠腫 / 晩発性放射線脳障害 / 放射線脳壊死 / 治療後再発 / ケモカイン

Outline of Final Research Achievements

Glioblastoma is one of incurable malignant brain tumors. Our present study demonstrated that the chronic pathophysiological changes after X-ray irradiation against the tumor may advantage its abilities of proliferation, invasion and angiogenesis, which might be able to promote the tumor recurrence paradoxically. Through examining the biological mechanisms of this phenomenon, we found out several candidates of the therapeutic molecular targets for suppressing the tumor relapse after radiotherapy.

Free Research Field

脳神経外科