Differential glycan profiling of MUC1 from pancreatic ductal adenocarcinoma and cholangiocarcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21667
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics; Bio-related chemistry
• Research Institution: Keio University (2016-2017); National Institute of Advanced Industrial Science and Technology (2015)
• Principal Investigator: Matsuda Atsushi 慶應義塾大学, 医学部(信濃町), 助教 (30722590)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: MUC1 / 腫瘍マーカー / 糖鎖 / レクチンアレイ / 膵臓癌 / 胆管癌 / ムチン

Outline of Final Research Achievements

This study demonstrate the development of the mucin glycan profiling targeting to surgical tissue sections from pancreatic ductal adenocarcinoma and cholangiocarcinoma. We establish the glycan profiling of mucin molecules derived from culture cells. Using this method, we next demonstrate the differential mucin glycan profiling targeting to surgical tissue sections from pancreatic ductal adenocarcinoma and cholangiocarcinoma. As the result, we find a specific glycan change according to tumor prognosis after the surgery. Our methodology is expected to applicate to newly biomarker and drug discovery in the future.

Free Research Field

糖鎖生物学