Diabetic patients clarify the mechanisms of inflammation and organ injury during extracorporeal membrane oxygenation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21692
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine; Cardiovascular surgery
• Research Institution: Niigata University of Health and Welfare (2016-2017); National Cardiovascular Center Research Institute (2015)
• Principal Investigator: Fujii Yutaka 新潟医療福祉大学, 医療技術学部, 助教 (20589303)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病 / 補助循環 / 炎症反応 / 酸化ストレス

Outline of Final Research Achievements

In this study, we aimed to elucidate the mechanisms of inflammation and organ injury which diabetic patients undergo during extracorporeal membrane oxygenation.
As a result of the pathological evaluation after the auxiliary circulation, it was found that the injury level tended to be higher in the proximal kidney tubule in the diabetic group.It was also shown that diabetic group was susceptible to inflammation and had high oxidative stress. Our research results can be a material to elucidate the mechanism of inflammation and organ injury suffered by diabetic patients during extracorporeal membrane oxygenation and the relationship between oxidative stress.

Free Research Field

循環生理学