Novel Boron containing Nanoparticles and their application in BNCT.

2019 Fiscal Year Final Research Report

• Project/Area Number: 15K21764
• Research Category: Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
• Allocation Type: Multi-year Fund
• Research Field: Nanomaterials chemistry
• Research Institution: Kyoto University
• Principal Investigator: TAMANOI Fuyuhiko 京都大学, 高等研究院, 特定教授 (10802283)
• Research Collaborator: Suzuki Minoru ; Saito Hiroyuki
• Project Period (FY): 2017 – 2019
• Keywords: メソポーラスシリカナノ粒子 / がん蓄積 / がんの鶏卵モデル / がんスフェロイド / ホウ素中性子捕捉療法 / 単色X線 / オージェ効果

Outline of Final Research Achievements

This research led to the development of various mesoporous silica-based nanoparticles that are promising for cancer therapy. Because these nanoparticles possess a large surface area, various chemicals can be attached to the nanoparticles. In one instance, we bound anticancer drugs and demonstrated the use of the nanoparticles for drug delivery. In another approach, we attached boron containing chemicals so that the nanoparticles can be used for boron neutron capture therapy. In yet another approach, we prepared nanoparticles containing gadolinium. This gadolinium containing nanoparticles could be used in combination with monochromatic X-ray to provide a new type of radiation therapy.

Academic Significance and Societal Importance of the Research Achievements

本研究の意義はメソポーラスシリカをベースにした新規のナノ粒子を開発することができた点にある。これらのナノ材料は抗がん剤のデリバリーに有効であり、またホウ素中性子捕捉療法や新規の放射線治療の開発に寄与する。特にガドリニウム含有ナノ粒子と単色X線を組み合わせた放射線実験により新規放射線治療の可能性を提示した。

Free Research Field

研究代表者はナノメディシンの研究を続けてきた。様々なナノ粒子を作成しがん治療への応用を目指している。