The role of canine AIM in histiocytic sarcoma(Fostering Joint International Research)

2017 Fiscal Year Final Research Report

• Project/Area Number: 15KK0275
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: The University of Tokyo
• Principal Investigator: Yonezawa Tomohiro 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10433715)
• Research Collaborator: Ruffell Brian Moffitt cancer research center
• Project Period (FY): 2016 – 2017
• Keywords: マクロファージ / 組織球性肉腫 / 犬

Outline of Final Research Achievements

Tumor-associated macrophage (TAM) is reported to be closely related to malignancy of tumorgenesis. However, it is unknown how macrophage can transverse into TAM. We have focused on a specific protein, apoptosis inhibitor of macrophage (AIM), which is expressed in macrophages. In this study, it is found that AIM is highly expressed in TAM and AIM inhibited apoptosis of these cells in vitro. It is also found that AIM could bind some factor of apoptosis pathway, suggesting that AIM should inhibit apoptosis via binding it.

Free Research Field

獣医学