2017 Fiscal Year Final Research Report
Regulation of lineage fate in hematopoietic stem cells by Bach2(Fostering Joint International Research)
| Project/Area Number |
15KK0328
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
McHeyzer-Williams Michael スクリプス研究所, Immunology and Microbiology, 教授
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| Project Period (FY) |
2015 – 2017
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| Keywords | 免疫記憶 / 獲得免疫 / 抗体産生 / 形質細胞 / メタロチオネイン / 亜鉛 |
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| Outline of Final Research Achievements |
Long-living plasma cells in bone marrow are key player of the memory of immunity. To elucidate the mechanism of long-living on plasma cells, we performed gene expression analysis using single cell RNA-sequencing (scRNA-seq). scRNA-seq analysis showed that MT1 and MT2 had high expression in bone marrow. These gene showed high correlation as expression level. We found that Hmox1 (HO-1) and Herped1, which are genes of anti-stress factors, highly expressing in MTs expressing cells in bone marrow. IL-6 stimulation increased MT1 and MT2 gene expression in spleen plasma cells. These result suggested that MT expressing cells have recieved survival factor stimulation in bone marrow.
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| Free Research Field |
免疫学
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