Genetic and Epigenetic Dysregulation in Cancer

2009 Fiscal Year Final Research Report

• Project/Area Number: 16059101
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Japanese Foundation For Cancer Research (2005-2009); Tohoku University (2004)
• Principal Investigator: NODA Tetsuo Japanese Foundation For Cancer Research, 癌研究所, 所長 (10183550)
• Co-Investigator(Kenkyū-buntansha): TAYA Youichi 国立がんセンター, 研究所 (60133641)
• Co-Investigator(Renkei-kenkyūsha): ISHIKAWA Fuyuki 京都大学, 生命科学研究科 (30184493) ; HANAOKA Fumio 学習院大学, 理学部, 教授 (50012670) ; YAMAMOTO Masayuki 東北大学, 医学系研究科 (50166823) ; HATAKEYAMA Masanori 東京大学, 大学院・医学系研究科 (40189551) ; NAKAMURA Takuro 財団法人癌研究会, 癌研究所 (00180373) ; TAKAI Yoshimi 神戸大学, 医学研究科 (60093514) ; NIWA Ohtsura 放射線医学研究所, 重粒子医科学センター (80093293) ; HIROHASHI Setsuo 国立がんセンター (70129625) ; SHIMOTONO Kunitada 千葉工業大学, 附属総合研究所 (10000259) ; SAYA Hideyuki 慶應義塾大学, 医学部 (80264282)
• Project Period (FY): 2004 – 2009
• Keywords: 遺伝学 / ウイルス / 癌 / ゲノム / 細胞・組織

Research Abstract

The research area for "Genetic and Epigenetic Dysregulation in Cancer" was organized to elucidate the molecular mechanisms for the process of cancer initiation and progression. This board for the research consists of section chiefs and leading investigators in this area and has been working to promote research activities of principle investigators through varied types of activity, such as the organization of researchers and the evaluation of their activities. We also organized workshops to promote information exchange among investigators. Our activity has substantially contributed for the promotion of research activity and the production of many novel scientific findings by investigators in the area.

Research Products

• [Journal Article] Structure and mechanism of human DNA polymeraseη (2010)
  • Author(s): C. Biertumpfel, Y. Zhao, Y. Kondo, S. Ramon-Maiques, M. Gregory, J.Y. Lee, C. Masutani, A.R. Lehmann, F. Hanaoka, W. Yang
  • Journal Title: Nature 465 Pages: 1044-1049
• [Journal Article] Novel regulation of the Nrf2-Keap1 pathway by the selective autophagy substrate p62 (2010)
  • Author(s): M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, Y. Ichimura, Y-S. Sou, I. Ueno, A. Sakamoto, K.I. Tong, M. Kim, S. Iemura, T. Natsume, T. Ueno, E. Kominami, H. Motohashi, K. Tanaka, M. Yamamoto
  • Journal Title: Nat. Cell Biol. 12 Pages: 213-223
• [Journal Article] Significance of PGP9. 5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma (2010)
  • Author(s): Y. Akishima-Fukasawa, Y. Ino, Y. Nakanishi, A. Miura, Y. Moriya, T. Kondo, Y. Kanai, S. Hirohashi
  • Journal Title: Am. J. Clin. Pathol. 134 Pages: 71-79
• [Journal Article] RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway (2009)
  • Author(s): Y. Miyake, M. Nakamura, A. Nabetani, S. Shimamura, M. Tamura, S. Yonehara, M. Saito, F. Ishikawa
  • Journal Title: Mol. Cell 36 Pages: 193-206
• [Journal Article] Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma (2009)
  • Author(s): T. Yamanashi, Y. Nakanishi, G. Fujii, Y. Akishima-Fukasawa, Y. Moriya, Y. Kanai, M. Watanabe, S. Hirohashi
  • Journal Title: Oncology. 77 Pages: 53-62
• [Journal Article] Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length (2008)
  • Author(s): T. Miyoshi, J. Kanoh, M. Saito, F. Ishikawa
  • Journal Title: Science 320 Pages: 1341-1344
• [Journal Article] GATA1-related leukaemias (2008)
  • Author(s): R. Shimizu, J.D. Engel, M. Yamamoto
  • Journal Title: Nat. Rev. Cancer 8 Pages: 279-287
• [Journal Article] Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse (2008)
  • Author(s): N. Ohnishi, H. Yuasa, S. Tanaka, H. Sawa, M. Miura, A. Matsui, H. Higashi, M. Musashi, K. wabuchi, M. Suzuki, G. Yamada, T. Azuma, M. Hatakeyama
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 1003-1008
• [Journal Article] Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation (2008)
  • Author(s): Y. Takai, J. Miyoshi, W. Ikeda, H. Ogita
  • Journal Title: Nat. Rev. Mol. Cell Biol. 9 Pages: 603-615
• [Journal Article] Aurora-A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice (2008)
  • Author(s): D. Zhang, T. Shimizu, N. Araki, T. Hirota, M. Yoshie, K. Ogawa, N. Nakagata, M. Takeya, H. Saya
  • Journal Title: Oncogene 27 Pages: 4305-4314
• [Journal Article] α-Catenin is essential in intestinal adenoma formation (2007)
  • Author(s): H. Shibata, H. Takano, M. Ito, H. Shioya, M. Hirota, H. Matsumoto, Y. Kakudo, C. Ishioka, T. Akiyama, Y. Kanegae, I. Saito, T. Noda.
  • Journal Title: Proc. Natl. Acad. Sci. USA 104 Pages: 18199-18204
• [Journal Article] TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton (2007)
  • Author(s): R. Yao, Y. Natsume, T. Noda
  • Journal Title: Cancer Sci. 98 Pages: 555-562
• [Journal Article] Helicobacter pylori CagA targets PAR-1/MARK kinase to disrupt epithelial cell polarity (2007)
  • Author(s): I. Saadat, H. Higashi, C. Obuse, M. Umeda, N. Murata-Kamiya, Y. Saito, H. Lu, N. Ohnishi, T. Azuma, A. Suzuki, S. Ohno, M. Hatakeyama
  • Journal Title: Nature 447 Pages: 330-333
• [Journal Article] Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis (2007)
  • Author(s): G. Jin, Y. Yamazaki, M. Takuwa, T. Takahara, K. Kaneko, T. Kuwata, S. Miyata, T. Nakamura
  • Journal Title: Blood 109 Pages: 3998-4005
• [Journal Article] The lipid droplet is an important organelle for hepatitis Cvirus production (2007)
  • Author(s): Y. Miyanri, K. Atsuzawa, N. Usuda, K. Watashi, T. Hishiki, M. Zayas, R. Bartenschlager, T. Wakita, M. Hijikata, K. Shimotohno
  • Journal Title: Nat. Cell Biol. 9 Pages: 1089-1097
• [Journal Article] UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex (2005)
  • Author(s): K. Sugasawa, Y. Okuda, M. Saijo, R. Nishi, N. Matsuda, G. Chu, T. Mori, S. Iwai, K. Tanaka, K. Tanaka, F. Hanaoka
  • Journal Title: Cell 121 Pages: 387-400
• [Journal Article] Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Nec1-5 with nectin-3 (2005)
  • Author(s): T. Fujito, W. Ikeda, S. Kakunaga, Y. Minami, M. Kajita, Y. Sakamoto, M. Monden, Y. Takai
  • Journal Title: J. Cell Biol. 171 Pages: 165-173
• [Journal Article] Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase (2005)
  • Author(s): K. watashi, N. Ishii, M. Hijikata, D. Inoue, T. Murata, Y. Miyanari, K. Shimotohno
  • Journal Title: Mol. Cell 19 Pages: 111-122
• [Journal Article] Aurora A - A guardian of poles (2005)
  • Author(s): T. Marumoto, D. Zhang, H. Saya
  • Journal Title: Nat. Rev. Cancer 5 Pages: 42-50
• [Journal Article] Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis
  • Author(s): T. Yokoyama, Y. Kanno, Y. Yamazaki, T. Takahara, S. Miyata, T. Nakamura
  • Journal Title: Blood (in press)
• [Remarks]
  • URL: http://gantoku3.umin.jp/index.html