2006 Fiscal Year Final Research Report Summary
Molecular basis for the control of intractable diseases through manipulation of osteopontin function.
| Project/Area Number |
16209014
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
UEDE Toshimitsu Hokkaido Univ., Inst. For Genetic Med., Prof., 遺伝子病制御研究所, 教授 (00160185)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Tadaaki Hokkaido Univ., Res. Ct. For Zoon. Cont., Prof., 人獣共通感染症リサーチセンター, 教授 (60272431)
KON Shigeyuki Hokkaido Univ., Inst. For Genetic Med., Inst., 遺伝子病制御研究所, 講師 (90344499)
ONO Etsurou Tottori Univ., Fac. Of Agri. AZRC., Prof., 農学部附属鳥由来人獣共通感染症疫学研究センター, 教授 (00160903)
YOKOSAKI Yasuyuki Hiroshima Univ., Health Service Center., Assoc. Prof., 保健管理センター, 助教授 (80210607)
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| Project Period (FY) |
2004 – 2006
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| Keywords | Osteopontin / neutralizing antibody / rheumatoid arthritis / integrin / siRNA |
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| Research Abstract |
It has been shown that the cryptic epitope, S162VVYGLR168, is exposed by the cleavage of human osteopontin (OPN) by thrombin and this epitope is recognized by a 4 and a 9 integrins.
1) We found that V164, Y105 and L167 residues are critical for the recognition by both a 9 and a 4 integrins in terms of cell adhesion and migration. While, R168 residue is critical for the recognition by a 9 integrin in cell adhesion and V163 is important for a 4 integrin in cell migration.
2) We also found that R168 residue transmits negative signal for Rho mediated-function when SVVYGLR is recognize by a 4 and a 9 integrins in cell migration.
3) OPN is also cleaved by MMP-3 and MMP-7 at a position of SVVYG166/L167R. We found that a 4 integrin, but not a 9 integrin is able to recognized MMP-cleaved from of OPN.
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Research Products
(54 results)
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[Journal Article] Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium.2007
Author(s)
S.Saika, K.Shirai, O.Yamanaka, KI.Miyazaki, Y.Okada, A.Kitano, KC.Flanders, S.Kon, T.Uede, WW.Kao, SR.Rittling, DT.Denhardt, Y.Ohnishi
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Journal Title
Lab Invest. 87
Pages: 130-138
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation.2007
Author(s)
N.Mori, T.Majima, N.Iwasaki, S.Kon, K.Miyakawa, C.Kimura, K.Tanaka, DT.Denhardt, S.Rittling, A.Minami, T.Uede
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Journal Title
Matrix Biol. 26
Pages: 42-53
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Osteopontin participates in Thl- mediated host resistance against nonlethal malaria parasite plasmodium chabaudi chabaudi infection in mice.2006
Author(s)
Y.Maeno, S.Nakazawa, N.Yamamoto, M.Shinzato, S.Nagashima, K.Tanaka, J.Sasaki, SR.Rittling, DT.Denhart, T.Uede, K.Taniguchi
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Journal Title
Infect Immun. 74
Pages: 2423-2427
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Role of the integrin-binding protein osteopontin in lymphatic metastasis of breast cancer.2006
Author(s)
AL.Allan, R.George, SA.Vantyghem, MW.Lee, NC.Hodgson, CJ.Engel.RL.Holliday, DP.Girvan, LA.Scott, CO.Postenka, W.Alkatib, LW.Stitt, T.Uede, AF.Chambers, AB.Tuck
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Journal Title
Am J Pathol. 169
Pages: 233-246
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] High plasma concentrations of osteopontin in patients with interstitial pneumonia.2005
Author(s)
J.Kadota, S.Mizunoe, K.Mito, H.Mukae, S.Yoshioka, K.Kawakami, Y.Koguchi, K.Fukushima, S.Kon, S.Kohno, A.Saito, T.Uede, M.Nasu
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Journal Title
Respir Med. 99
Pages: 111-117
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Osteopontin as a positive regulator in the osteoclastogensis of arthritis.2004
Author(s)
T.Ishii, S.Ohshima, T.Ishida, T.Mima, Y.Tabunoki, H.Kobayashi, M.Maeda, T.Uede, L.Liaw, N.Kinoshita, I.Kawase, Y.Saeki
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Journal Title
Biochem Biophys Res Commun. 316
Pages: 809-815
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy.2004
Author(s)
Y.Matsui, N.Jia, H.Okamoto, S.Kon, H.Onozuka, M.Akino, K.Liu, J.Morimoto, SR.Rittling, D.Denhardt, A.Kitabatake, T.Uede
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Journal Title
Hypertension. 43
Pages: 1195-1201
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Mice with osteopontin deletion remain predisposed to collagen-induced arthritis.2004
Author(s)
T.Ishii, S.Ohshima, T.Ishida, I.Kawase, T.Mima, Y.Tabunoki, H.Kobayashi, M.Maeda, T.Uede, L.Liaw, N.Kinoshita, Y.Saeki
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Journal Title
Arthritis Rheum. 50
Pages: 669-671
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.2004
Author(s)
H.Diao, S.Kon, K.Iwabuchi, C.Kimura, J.Morimoto, D.Ito, T.Segawa, M.Maeda, J.Hamuro, T.Nakayama, M.Taniguchi, H.Yagita, L.V.Kaer, K.Onoe, D.Denhardt, S.Rittling, T.Uede
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Journal Title
Immunity. 21
Pages: 539-550
Description
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