• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2006 Fiscal Year Final Research Report Summary

Mechanisms of prostaglandin E2 production, secretion, and exclusion in the brain during fever.

Research Project

Project/Area Number 16390059
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionOsaka Institute of Technology (2005-2006)
Kyoto University (2004)

Principal Investigator

MATSUMURA Kiyoshi  Osaka Institute of Technology, Faculty of Information Science and Technology, Professor, 情報科学部, 教授 (10157349)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Shigeo  Kyoto University, Graduate School of Informatics, Professor, 情報学研究科, 教授 (40124797)
HOSOKAWA Hiroshi  Kyoto University, Graduate School of Informatics, Lecturer, 情報学研究科, 講師 (90359779)
Project Period (FY) 2004 – 2006
Keywordsprostaglandin / cyclooxygenase / fever / phospholipase A2 / arachidonic acid / brain endothelial cell / organic anion transporter / arachnoidal membrane
Research Abstract

Mechanism of prostaglandin E_2 (PGE_2) production during fever
・Microsomal prostaglandin E synthase (mPGES) is indispensable for brain PGE_2 production induced by lipopolysachharide (LPS).
・In mice, LPS induces cyclooxygenase-2 (COX-2) in brain endothelial cells but not mPGES MPGES is constitutively expressed in arachnoidal membrane. These results suggest that trans-cellular biosynthesis of PGE_2 takes place in endothelial cells and arachnoidal cells.
・Calcium-independent PLA_2 (iPLA_2) is involved in LPS-induced fever
・iPLA_2 also suppresses LPS-induced COX-2 in the brain, and LPS-induced inflammatory cytokines, suggesting its multiple roles in inflammatory reaction to LPS.
・Arachidonic acid (AA), the major product of PLA_2, induces COX-2 in brain endothelial cells, when injected into the brain. This result means that AA is not only the substrate for PGE_2 biosynthesis but also an inducer of COX-2.
・AA-induced COX-2 induction is due to the direct action of AA rather than indirect action via AA metabolites.
・Interleukin-6 plays an essential role in carrageenan-induced COX-2 expression in brain endothelial cells.
Brain expression of organic anion transporters which possibly transport PGE_2
・Prostaglandin transporter (PGT) is constitutively expressed in arachnoidal membrane of the rat brain
・LPS induces further PGT transcription in arachnoidal membrane and brain endothelial cells.
・Multidrug resistance protein 4 (MRP4) is expressed in brain endothelial cells.

  • Research Products

    (15 results)

All 2007 2006 2005 Other

All Journal Article (15 results)

  • [Journal Article] Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS.2007

    • Author(s)
      Oka Y, Ibuki T, Matsumura K, Namba M, Yamazaki Y, Poole S, Tanaka Y, Kobayashi S
    • Journal Title

      Neuroscience 145

      Pages: 530-538

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS.2007

    • Author(s)
      Oka Y, Ibuki T, Matsumura K, Namba M, Yamazaki Y, Poole S, Tanaka Y, Kobayashi S.
    • Journal Title

      Neuroscience 145

      Pages: 530-538

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Paradigm shift in sensory system-Animals do not have sensors2006

    • Author(s)
      Kobayashi S, Okazawa M, Hori A, Matsumura K, Hosokawa H
    • Journal Title

      Journal of Thermal Biology 31

      Pages: 19-23

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cellular and molecular bases of the initiation of fever2006

    • Author(s)
      Steiner AA, Ivanov AI, Serrats J, Hosokawa H, Phayre AN, Robbins JR, Roberts JL, Kobayashi S, Matsumura K, Sawchenko PE, Romanovsky AA
    • Journal Title

      PLoS Biol 4

      Pages: e284

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region2006

    • Author(s)
      Takemiya T, Maehara M, Matsumura K, Yasuda S, Sugiura H, Yamagata K
    • Journal Title

      Neurosci Res 56

      Pages: 103-110

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8.2006

    • Author(s)
      Abe J, Hosokawa H, Sawada Y, Matsumura K, Kobayashi S.
    • Journal Title

      Neurosci Lett 397

      Pages: 140-144

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Paradigm shift in sensory system--Animals do not have sensors.2006

    • Author(s)
      Kobayashi S, Okazawa M, Hori A, Matsumura K, Hosokawa H.
    • Journal Title

      Journal of Thermal Biology 31

      Pages: 19-23

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cellular and molecular bases of the initiation of fever.2006

    • Author(s)
      Steiner AA, Ivanov AI, Serrats J, Hosokawa H, Phayre AN, Robbins JR, Roberts JL, Kobayashi S, Matsumura K, Sawchenko PE, Romanovsky AA.
    • Journal Title

      PLoS Biol 4

      Pages: e284

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region.2006

    • Author(s)
      Takemiya T, Maehara M, Matsumura K, Yasuda S, Sugiura H, Yamagata K.
    • Journal Title

      Neurosci Res 56

      Pages: 103-110

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] TRPM8 protein localization in trigeminal ganglion and taste papillae2005

    • Author(s)
      Abe J, Hosokawa H, Okazawa M, Kandachi M, Sawada Y, Yamanaka K, Matsumura K, Kobayashi S
    • Journal Title

      Brain Res Mol Brain Res 136

      Pages: 91-98

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Sympathetic premotor neurons mediating thermoregulatory functions2005

    • Author(s)
      Nakamura K, Matsumura K, Kobayashi S, Kaneko T
    • Journal Title

      Neurosci Res 51

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus.2005

    • Author(s)
      Nakamura Y, Nakamura K, Matsumura K, Kobayashi S, Kaneko T, Morrison SF
    • Journal Title

      Eur J Neurosci 22

      Pages: 3137-3146

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Sympathetic premotor neurons mediating thermoregulatory functions.2005

    • Author(s)
      Nakamura K, Matsumura K, Kobayashi S, Kaneko T.
    • Journal Title

      Neurosci Res 51

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus.2005

    • Author(s)
      Nakamura Y, Nakamura K, Matsumura K, Kobayashi S, Kaneko T, Morrison SF.
    • Journal Title

      Eur J Neurosci 22

      Pages: 3137-3146

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ca^<2+>-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8

    • Author(s)
      Abe J, Hosokawa H, Sawada Y, Matsumura K, Kobayashi S
    • Journal Title

      Neurosci Lett 397

      Pages: 140-144

    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2008-05-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi