2005 Fiscal Year Final Research Report Summary
An epidemiological study of maternal dioxins exposure and infant growth
| Project/Area Number |
16590489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | KANAZAWA MEDICAL UNIVERSITY |
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Principal Investigator |
NAKAGAWA Hideaki Kanazawa Medical University, Medicine, Professor, 医学部, 教授 (00097437)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIIO Muneko Kanazawa Medical University, Medicine, Associateo, Prof., 医学部, 助教授 (40198461)
MORIKAWA Yuko Kanazawa Medical University, Medicine, Associate, Prof., 医学部, 助教授 (20210156)
MIURA Katsuyuki Kanazawa Medical University, Medicine, Associate Prof., 医学部, 助教授 (90257452)
NAKANISHI Yumiko Kanazawa Medical University, Medicine, Lecturer, 医学部, 講師 (90350793)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Dioxin / the next generation / infant growth / epidemiological survey / food preference / head circumference / fish / vegetable |
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| Research Abstract |
In this study, we examined the relationship between infant growth and the concentration of dioxins in breast milk as an indicator of maternal exposure. A total of 44 milk samples were obtained on the 5-8^<th> postpartum day from mothers in Japan exposed to dioxins at the background level. The levels of 7 dioxins and 10 furan isomers were measured in each milk sample using an HR-GC/MS system. The levels of isomers in these subjects were lower than those in urban areas, showing similar isomer pattern as other areas. The HxCDD concentration negatively correlated with newborn head circumference and meight, even after adjustment for gestational age, infant sex, parity and other confounding factors. However, there was significant positive correlation between infant height at 1 month old and HpCDF in breast milk, which was related to amount and frequency of fish intake. Therefore, maternal fish intake might help infant growth after birth due to breast feeding, even if dioxins and frans were increased in breast milk. On the other hand, HxCDD in breast milk in mothers who preferred to take a lot of green vegetable was higher than that in mothers who didn't eat much. These facts suggested that dioxins/frans contamination from vegetable due to agricultural chemicals might affect on fetal development.
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