2005 Fiscal Year Final Research Report Summary
Effect of Granulocyte Colony-Stimulating Factor Treatment at a Low Dose but Long Duration in Patients with Coronary Heart Disease
| Project/Area Number |
16590668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | GIFU UNIVERSITY |
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Principal Investigator |
NISHIGAKI Kazuhiko Gifu University, University Hospital, Associate Professor, 医学部附属病院, 助教授 (60198447)
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| Co-Investigator(Kenkyū-buntansha) |
MINATOGUCHI Shinya Gifu University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (20190697)
ARAI Masazumi Gifu University, University Hospital, Assistant Professor, 医学部附属病院, 講師 (00202721)
FUJIWARA Hisayoshi Gifu University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (80115930)
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| Project Period (FY) |
2004 – 2005
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| Keywords | G-CSF / Angina / Thallium 201 / CD34 positive cells / proliferation of microvessel / Regeneration therapy / leukocytes |
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| Research Abstract |
Background
In animal models, granulocyte colony-stimulating factor (G-CSF) improves post-infarct cardiac function. However, in pilot studies of the patients with angina and acute myocardial infarction (AMI), G-CSF at a high dose frequently induced coronary occlusion or restenosis, but those at a low dose showed no significant beneficial effect. We hypothesized that a low dose but long duration of G-CSF will have a beneficial effect without serious complications to patients with intractable angina pectoris.
Methods and Results
22 patients with angina were randomly assigned into G-CSF and non-G-CSF control groups, respectively. Recombinant G-CSF was subcutaneously injected once a day for 10 days. The leukocyte counts in the peripheral blood were controlled at approximately 30,000/□l. One month later, chest pain in the patients improved in the G-CSF-treated group. Tl-201 single photon emission computed tomography (SPECT) revealed the increased %uptake and the reduced extent and severity scores in the G-CSF-treated group. The number of CD34 positive cells in the peripheral blood was 0.6/μl before treatment and increased to 3.9/μl after the therapy.
Conclusions
A low dose but long duration of G-CSF treatment may have a beneficial effect without any serious complications in patients with angina pectoris.
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Research Products
(12 results)
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[Journal Article] Effect of Granulocyte Colony-Stimulating Factor Treatment at a Low Dose but for a Long Duration in Patients With Coronary Heart Disease-A Pilot Study-2006
Author(s)
Suzuki K, Nagashima K, Arai M, Uno Y, Misao Y, Takemura G, Nishigaki K, Minatoguchi S, Watanabe S, Tei C, Fujiwara H
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Journal Title
Circ J 70(4)
Pages: 430-437
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] In Vivo Quantitative Tissue Characterization of Angiographically Normal Coronary Lesions and the Relation With Risk Factors -A Study Using Integrated Backscatter Intravascular Ultrasound-2005
Author(s)
Sano K, Kawasaki M, Okubo M, Yokoyama H, Ito Y, Murata I, Kawai T, Tsuchiya K, Nishigaki K, Takemura G, Minatoguchi S, Zhou X, Fujita H, Fujiwara H
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Journal Title
Circ J 69(5)
Pages: 543-549
Description
「研究成果報告書概要(欧文)」より
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