2005 Fiscal Year Final Research Report Summary
Treatment of hepatocellular carcinoma after liver transplantation by graft versus tumor effcect using bone marrow co-transplantation
| Project/Area Number |
16591254
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka University |
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Principal Investigator |
DONO Keizo Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (60283769)
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| Co-Investigator(Kenkyū-buntansha) |
NAGANO Hiroaki Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (10294050)
MARUBASHI Shigeru Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (20362725)
MONDEN Morito Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00127309)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Liver transplantation / Hepatocellular carcinoma / Bone marrow transplantation / Graft versus tumor effect / Micro metastasis |
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| Research Abstract |
Liver transplantation has been established as an effective treatment for hepatocellular carcinoma with complete resection of tumors and restoration of liver function. However advanced cancer patients may already have extra hepatic lesions at the time of transplantation, which lead to recurrence of tumor after transplantation. Several adjuvant attempts has been made to reduce tumor recurrent rate after transplantation, but failed to confirm effectiveness.
In this study, we tried to show that liver transplantation together with bone marrow transplantation from the same donor can prevent recipients from recurrence by graft versus tumor effect of inoculated bone marrow derived immune cells.
In animal model, establishment of stable bone marrow chimera was difficult in cancer baring mice. Unfortunately we could not show direct anti cancer effect of co-transplanted marrow cells, the concept of graft versus tumor effect against residual solid tumor is attractive and further trial should be made in the future.
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[Journal Article] J Surg Res2005
Author(s)
Hayashi S., et al.
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Journal Title
New measurement of hepatic blood flow by xenon CT system : an animal study with PGE1. 129.1
Pages: 24-30
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Arch Histol Cytol.2005
Author(s)
Lu Z., et al.
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Journal Title
Participation of autophagy in the degeneration process of rat hepatocytes after transplantation following prolonged cold preservation. 68.1
Pages: 71-80
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Transplantation2005
Author(s)
Marubashi S., et al.
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Journal Title
Steroid-free living-donor liver transplantation in adults. 80.5
Pages: 704-706
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Transplantation.2005
Author(s)
Marubashi S., et al.
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Journal Title
Living-donor liver transplantation with renoportal anastomosis for patients with large spontaneous splenorenal shunts. 80.12
Pages: 1671-1675
Description
「研究成果報告書概要(和文)」より
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[Journal Article] J Gastrointest Surg.2005
Author(s)
Marubashi S., et al.
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Journal Title
Portal venous reconstruction in a living liver donor with an anomalous hepatic arterial and portal venous anatomy. 9.3
Pages: 365-368
Description
「研究成果報告書概要(和文)」より
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[Journal Article] J Hepatol.2004
Author(s)
Kobayashi S., et al.
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Journal Title
In vivo real-time microangiography of the liver in mice using synchrotron radiation. 40.3
Pages: 405-408
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Surgery,2004
Author(s)
Marubashi, M., et al.
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Journal Title
Effect of portal hemodynamics on liver regeneration studied in a novel portohepatic shunt rat model. 136.5
Pages: 1028-1037
Description
「研究成果報告書概要(和文)」より
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