2006 Fiscal Year Final Research Report Summary

Fund a mental research for treatment of keloid and hypertrophic scar

Research Project

Project/Area Number	16591805
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Plastic surgery
Research Institution	Osaka Medical College
Principal Investigator	UEDA Koichi Osaka Medical College, Faculty of Medicine, Professor, 医学部, 教授 (90257858)
Co-Investigator(Kenkyū-buntansha)	TSUJI Motomu Osaka Medical College, Faculty of Medicine, Associate Professor, 医学部, 准教授 (60144466) OBA Sosuke Osaka Medical College, Faculty of Medicine, Associate Professor, 医学部, 准教授 (80233253) YASUDA Yoshiko Kinki University, Faculty of Medicine, Professor, 医学部, 教授 (10025629)
Project Period (FY)	2004 – 2006
Keywords	keloid / hypertrophic scar / immunohistochemistry / VEGF
Research Abstract	We have previously shown that the adenosine triphosphate (ATP) content of keloids remains high for a long time. In keloids, anaerobic glycolysis may be related to the production of ATP. In this study, we counted the vessels in keloids, hypertrophic and atrophic scars in a defined area, and measured the cross-sectional areas of their internal lumens immunohistopathologically and the lactate concentrations. The mean number in a defined area was smallest in keloids as was the mean internal area of vessels. The decreased and narrowed vessels may reduce oxygen perfusion. The blood supply to keloids is inadequate, and this persists.

(2 results)