• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Photosensitivity and gene abnormality in circadian rhythm sleep disorders

Research Project

Project/Area Number 16614005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 睡眠学
Research InstitutionShiga University of Medical Science

Principal Investigator

OKAWA Masako  Shiga University of Medical Science, Department of Psychiatry, Professor, 医学部, 教授 (80160430)

Co-Investigator(Kenkyū-buntansha) KANAI Hirohiko  Shiga University of Medical Science, Department of Psychiatry, Assistant Professor, 医学部, 講師 (30293830)
OZEKI Yuji  Shiga University of Medical Science, Department of Psychiatry, research associate, 医学部, 助手 (90303768)
KONISHI Mizuho  Shiga University of Medical Science, Department of Psychiatry, Research Assistant, 医学部, 教務職員 (90378448)
Project Period (FY) 2004 – 2005
KeywordsPhotosensitivity / Gene / Biological rhythm / Temperature / Melatonin
Research Abstract

Objectives of the study were to investigate the efficacy of hospitalization treatment with giving light therapy and social cues and to clarify their psychological characteristics using Picture-Frustration Study (P-F Study). The participants were 30 patients with circadian rhythm sleep disorders (18 delayed sleep phase syndrome ; DSPS patients, 5 non-24 hour sleep wake syndrome, 7 irregular sleep-wake rhythm) with school refusal during adolescence consisting of 20 boys and 10 girls (mean age±SD=16.0±1.4,range = 13-18) staying our ward during the period of between April 2004 and December 2005.
Over 90% of patients with school refusal improved their sleep-wake rhythm just after hospitalization, over 50% of them continued to improve their sleep-wake rhythm after discharge and were able to attend school after that. Significances between groups of improvement (I) and un-improvement (UI) in sleep wake rhythms were observed in the age of hospitalization, and the age of onset. I group showed higher ages of hospitalization and onset than UI group. The psychological characteristics for DSPS patients with school refusal, especially in patients who were not able to improve sleep-wake rhythm and school refusal after discharge were low aggression, low expression of their dissatisfaction, high suppression of their emotion, low social interest and high self-reproof. Patients who did not show improvement their sleep-wake rhythm through hospitalization have some psychological problems such as those mentioned above. Therefore, they may need to take psychological intervention such as the self-assertion training. Hospitalization and light therapy is useful for the treatment of circadian rhythm sleep disorders. The gene morphism study for patients have been undertaking in our laboratory.

  • Research Products

    (17 results)

All 2005 2004

All Journal Article (16 results) Book (1 results)

  • [Journal Article] Cerebral white matter blood flow is constant during human non-rapid eye movement sleep : a positron emission tomographic study2005

    • Author(s)
      Hiroki M, Uema T, Kajimura N, Ogawa K, Nishikawa M, Kato M, Watanabe T, Nakajima T, Takano H, Imabayashi E, Ohnishi T, Takayama Y, Matsuda H, Uchiyama M, Okawa M, Takahashi K, Fukuyama H
    • Journal Title

      J Appl Physiol 98

      Pages: 1846-1854

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Clinical analyses of sighted patients with non-24-hour sleep-wake syndrome : A study of 57 consecutively diagnosed cases.2005

    • Author(s)
      Hayakawa T, Uchiyama M, Kamei Y, Shibui K, Tagaya H, Asada T, Okawa M, Urata J, Takahashi K
    • Journal Title

      Sleep 28(8)

      Pages: 945-952

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Seasonal variations of mood and behavior among Japanese graduate students2005

    • Author(s)
      Pallos H, Yamada N, Miyazaki S, Okawa M
    • Journal Title

      Sleep and Biological Rhythms 3(1)

      Pages: 27-31

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Explording the quality of sleep on long-term sojourn : international graduate students in Japan2005

    • Author(s)
      Pallos H, Gergely V, Yamada N, Miyazaki S, Okawa M
    • Journal Title

      Sleep and Biological Rhythms 3(3)

      Pages: 142-148

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The relation between negative emotional suppression and emotional distress in breast cancer diagnosis and treatment2005

    • Author(s)
      Iwamitsu Y, Shimoda K, Abe H, Tani T, Okawa M, Buck R
    • Journal Title

      Health Commun 18(3)

      Pages: 201-215

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 概日リズム睡眠障害および朝型・夜型の分子生物学2005

    • Author(s)
      松尾 雅博, 尾関 祐二, 大川 匡子
    • Journal Title

      分子精神医学 5(1)

      Pages: 32-39

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cerebral white matter blood flow is constant during human non-rapid eye movement sleep : a positron emission tomographic study2005

    • Author(s)
      Hiroki M, Uema T, Kajimura N, Ogawa K, Nishikawa M, Kato M, Watanabe T, Nakajima T, Takano H, Imabayashi E, Ohnishi T, Takayama Y, Matsuda H, Uchiyama M, Okawa M, Takahashi K, Fukuyama H
    • Journal Title

      J Appl Physiol 98(5)

      Pages: 1846-1854

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Seasonal variations of mood and behavior among Japanese graduate students.2005

    • Author(s)
      Pallos H, Yamada N, Miyazaki S, Okawa M
    • Journal Title

      Sleep and Biological Rhythms 3(1)

      Pages: 27-31

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Explording the quality of sleep on long-term sojourn : international graduate students in Japan.2005

    • Author(s)
      Pallos H, Gergely V, Yamada N, Miyazaki S, Okawa M
    • Journal Title

      Sleep and Biological Rhythms 3(3)

      Pages: 142-148

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The relation between negative emotional suppression and emotional distress in breast cancer diagnosis and treatment.2005

    • Author(s)
      Iwamitsu Y, Shimoda K, Abe H, Tani T, Okawa M, Buck R
    • Journal Title

      Health Commun 18(3)

      Pages: 201-215

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular biology for circadian rhythm disorder and morning-evening preference2005

    • Author(s)
      Matsuo M, Ozeki Y, Okawa M
    • Journal Title

      Japanese Journal of Molecular Psychiatry 5(1)

      Pages: 32-39

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Deactivation by benzodiazepine of the basal forebrain and amygdala in normal humans during sleep : A placebo-controlled [^<15>O〕H_2O pet study2004

    • Author(s)
      Kajimura N, Nishikawa M, Uchiyama M, Kato M, Watanabe T, Nakajima T, Honi T, Nakabayashi T, Sekimoto M, Ogawa K, Takano H, Imabayashi E, Hiroki M, Onishi T, Uema T, Takayama Y, Matsuda H, Okawa M, Takahashi K
    • Journal Title

      Am J Psychiatry 161(4)

      Pages: 748-751

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Serum melatonin levels and insomnia in patients with Machado-Joseph Disease2004

    • Author(s)
      Takei A, Fukazawa T, Hamada T, Sohma H, Yabe I, Sasaki H, Okawa M
    • Journal Title

      Sleep and Biological Rhythms 2(3)

      Pages: 209-214

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Paroxetine内服中に低ナトリウム血症を来し、SIADHと診断された2高齢患者2004

    • Author(s)
      市村 麻衣, 森田 幸代, 田中 和秀, 廣兼 元太, 下田 和孝, 山田 尚登, 大川 匡子
    • Journal Title

      精神医学 46(5)

      Pages: 505-511

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Deactivation by benzodiazepine of the basal forebrain and amygdala in normal humans during sleep : A placebo-controlled [^<15>O]H2O pet study.2004

    • Author(s)
      Kajimura N, Nishikawa M, Uchiyama M, Kato M, Watanabe T, Nakajima T, Hori T, Nakabayashi T, Sekimoto M, Ogawa K, Takano H, Imabayashi E, Hiroki M, Onishi T, Uema T, Takayama Y, Matsuda H, Okawa M, Takahashi K
    • Journal Title

      Am J Psychiatry 161(4)

      Pages: 748-751

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Two elderly patients with hyponatremia diagnosed as SLADH, after taking paroxetine.2004

    • Author(s)
      Ichimura M, Morita S, Tanaka K, Hirokane G, Shimoda K, Yamada N, Okawa M
    • Journal Title

      Clinical Psychiatry 46(5)

      Pages: 505-511

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Pathogenesis of delayed sleep phase syndrome.In2005

    • Author(s)
      Okawa M, Yamada N: Circadian rhythm in sleep
    • Total Pages
      143-152
    • Publisher
      Biological rhythms
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi