2018 Fiscal Year Final Research Report

Prospective cohort study for dementia and depression in the Hisayama elderly population based on brain MRI

Research Project

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Project/Area Number	16H02644
Research Category	Grant-in-Aid for Scientific Research (A)
Allocation Type	Single-year Grants
Section	一般
Research Field	Epidemiology and preventive medicine
Research Institution	Kyushu University
Principal Investigator	Ninomiya Toshiharu 九州大学, 医学研究院, 教授 (30571765)
Co-Investigator(Kenkyū-buntansha)	神庭重信九州大学, 医学研究院, 教授 (50195187) 北園孝成九州大学, 医学研究院, 教授 (70284487) 秦淳九州大学, 医学研究院, 准教授 (00448432) 小原知之九州大学, 医学研究院, 助教 (20623630) 吉田大悟九州大学, 医学研究院, 助教 (10596828)
Project Period (FY)	2016-04-01 – 2019-03-31
Keywords	認知症 / うつ病 / 疫学研究 / 頭部MRI / 危険因子
Outline of Final Research Achievements	In this study, we investigate the risk factors for the brain structural change by using brain MRI data in the Hisayama elderly population. In 2017, we completed the Brain MRI examination in the Hisayama residents aged 65 years or older. In addition, we have reported the prevalence of microbleeds and their risk factors in the English journal. In 2018, we estimated the association between albuminuria and white matter lesion. As a consequence, higher albuminuria level was significantly associated with greater volume of white matter lesion. Moreover, the investigation regarding the association between serum glycated albumin level and brain volume found the significant negative association between serum glycated albumin level and brain volume, especially hippocampal volumes. We will report these results in English journals.
Free Research Field	疫学研究
Academic Significance and Societal Importance of the Research Achievements	精度の高い久山町の前向きコホート研究の成績に頭部MRI検査による詳細な画像データを加えることにより、脳の形態学的変化が将来の認知機能低下及び認知症・うつ病の発症に及ぼす影響を明らかにするとともに、脳形態の縦断的変化に寄与する危険因子を同定する。この研究から得られる成果は、わが国の高齢者における認知症やうつ病の病態解明やその予防対策の確立に寄与し、引いては国民の保健・医療・福祉の向上につながることが期待される。