Development of integrated enzymatic biosensor based on mesoporous materials

2020 Fiscal Year Final Research Report

• Project/Area Number: 16H04160
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Ibaraki University
• Principal Investigator: Yamaguchi Akira 茨城大学, 理工学研究科(理学野), 教授 (10359531)
• Co-Investigator(Kenkyū-buntansha): 伊藤 徹二 国立研究開発法人産業技術総合研究所, 材料・化学領域, 主任研究員 (70392587)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: メソ多孔材料 / 酵素センサー

Outline of Final Research Achievements

The purpose of this study is development of advanced enzymatic biosensor by utilizing meso-sized cavity. For that purpose, we examined structure and function of enzyme confined inside the meso-sized cavity and designed biosensor based on the confined enzyme. As the result, we found that the structure and function of the confined enzyme were affected by size and surface characteristics of the cavity. In addition, highly sensitive biosensor was successfully developed.

Free Research Field

分析化学

Academic Significance and Societal Importance of the Research Achievements

バイオセンサーは予防医療の発展を支える基盤診断技術であり，国際的な研究開発競争が繰り広げられている。次世代バイオセンサー開発戦略の一つが，酵素の長期安定化によるセンサー寿命の改良および高感度化であり，安定化機構の解明に関わる学術的研究と高感度化に関わる新規技術創出を本研究で達成した。本研究で得られた成果は，体内バイオマーカーの簡易診断技術としての発展が期待される。