Induction of placental maturation at induced parturiton in cows

2019 Fiscal Year Final Research Report

• Project/Area Number: 16H05040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: HIRAYAMA Hiroki 東京農業大学, 生物産業学部, 教授 (60390861)
• Co-Investigator(Kenkyū-buntansha): 古山 敬祐 大阪府立大学, 生命環境科学研究科, 講師 (50611026)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 牛 / 分娩 / 胎盤停滞

Outline of Final Research Achievements

In this study, the administration of glucocorticoids induced the expression of genes involved in prostaglandin synthesis in placentomes at parturition. The expression of C-C chemokines was increased in placentomes at spontaneous parturition. C-C chemokines are responsible for the recruitment of the leukocytes to the site of inflammation. However, the administration of glucocorticoids did not influence the expression of C-C chemokines. These results suggest that further studies on administration methods of glucocorticoids are needed in order to reduce the incidence of retained fetal membrane after parturition.

Free Research Field

家畜繁殖学

Academic Significance and Societal Importance of the Research Achievements

繁殖牛の適正な分娩管理は、分娩時の事故による母体や子牛の損耗を防ぐとともに、分娩した個体の生殖機能回復を早めることで繁殖効率の向上につながる。本研究の成果は、分娩牛に発生する重要な疾患の一つである胎盤停滞の発生メカニズムの解明や分娩誘起技術の改良を通じて、牛の繁殖効率向上による乳肉など畜産物の安定的生産に寄与するものである。