2018 Fiscal Year Final Research Report
Analysis of molecular mechanisms of Wnt5a-Ror signaling in repair after tissue damage, inflammation, and cancer progression
| Project/Area Number |
16H05152
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内匠 透 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (00222092)
西田 満 神戸大学, 医学研究科, 准教授 (30379359)
遠藤 光晴 神戸大学, 医学研究科, 講師 (90436444)
林 真琴 神戸大学, 医学研究科, 助教 (50722930)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Wnt5a-Rorシグナル / 神経損傷修復 / 神経炎症 / がんの浸潤 / 骨格筋損傷修復 / 組織損傷修復 / 遺伝子発現制御 |
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| Outline of Final Research Achievements |
It has been well established that Ror1 and Ror2 receptor tyrosine kinases play important roles in developmental morphogenesis and tissue-/organo-genesis by acting as receptors for Wnt5a. In this study, we have shown that Ror1 and Ror2 play important roles in regulating repair and inflammatory responses after damage of brain neocortex and skeletal muscle by using experimental animal models. Furthermore, we show that Ror2 as well as Ror1 are expressed at high levels in various types of cancer cells, including osteosarcoma cells, breast cancer cells, malignant pleural mesotheliomas, and colo-rectal cancer cells, thereby promoting invasion of these cancer cells by activating similar and/or different signaling pathways.
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| Free Research Field |
分子細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、受容体型チロシンキナーゼRor1、Ror2は組織損傷修復において重要な役割を担うことが明らかとなり、今後Ror1、Ror2の発現・機能を制御することにより、損傷組織の修復や再生医療に応用できると予想される。また、Ror1、Ror2はがんの進展・増悪における浸潤過程において重要な役割を担うことが見出され、がんの新たな診断・治療法の開発における分子標的となることが期待される。
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