Effect of Japanese food component on marker of athrosclerosis, research using metabolome measurement

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H05241
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Tohoku University
• Principal Investigator: Atsushi Hozawa 東北大学, 東北メディカル・メガバンク機構, 教授 (00432302)
• Research Collaborator: Nakamura Tomohiro ; Hirata Takumi ; Kogure Mana ; Oikawa Maki ; Kisara Fuko ; Yang Yunqing ; Igarashi Yuka ; Ichinohasama Fumi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 動脈硬化 / 疫学 / メタボローム

Outline of Final Research Achievements

We measured information on metabolome. Participants of this study was (1) participants of Tohoku Medical Megabank Community Cohort Study (2) who measured cervical intina medina thickness(IMT), and (3) whose IMT was upper 25% or lower 25%. We selected participants considering age sex subgroup. Finally, we completed metabolome measurement from 2002 participants. We analyzeｄ the relation of IMT thickness with 165 items of metabolome measured by LC-MS and 37 items of metabolome measured by NMR. As a result, 3 items measured by LC-MS and 9 items measured by NMR was significantly associated with IMT thickness adjusting for age and sex.

Free Research Field

疫学

Academic Significance and Societal Importance of the Research Achievements

生活習慣が頸動脈硬化、ひいては脳心血管疾患に影響を与えることは良く知られている。しかしながらどのようなメカニズムを介して疾患につながるかはまだ明らかとはなっていない。本研究ではどのような代謝物質が動脈硬化肥厚者で高くなっているかを確認することを通じ、動脈硬化の早期マーカーをとらえることが可能になる。今後の創薬や早期診断マーカーの確立につながる意義のある研究であると考える。