がん重粒子線治療の高度化と治療個別化の為の基礎的・臨床的研究

2019 Fiscal Year Annual Research Report

• Project/Area Number: 16H05388
• Research Institution: Gunma University
• Principal Investigator: 中野 隆史 群馬大学, その他部局等, 特別教授 (20211427)
• Co-Investigator(Kenkyū-buntansha): 白井 克幸 自治医科大学, 医学部, 教授 (10400748) ; 岡本 雅彦 群馬大学, 医学部附属病院, 講師 (10451725) ; 田巻 倫明 福島県立医科大学, 医学部, 准教授 (20400749) ; 柴田 淳史 群馬大学, 未来先端研究機構, 准教授 (30707633) ; 若月 優 自治医科大学, 医学部, 非常勤講師 (40399449) ; 鈴木 義行 福島県立医科大学, 医学部, 教授 (60334116) ; 野田 真永 埼玉医科大学, 医学部, 教授 (60396645) ; 齋藤 淳一 富山大学, 学術研究部医学系, 教授 (70572816) ; 河村 英将 群馬大学, 大学院医学系研究科, 准教授 (80431716) ; 鳥飼 幸太 群馬大学, 医学部附属病院, 准教授 (90443077)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 重粒子線治療 / 個別最適化 / PD-L1 / 線量堆積解析

Outline of Annual Research Achievements

炭素イオン線治療の個別最適化のための研究をおこない、以下の成果を発表した。第一に、保険適応の拡大を目指し、様々ながん種や病態に対する炭素イオン線治療成績を解析し、成果を発表した：頭頸部がん（Takayasu et al. Cancer Medicine）、口腔がん（Ikawa et al. Cancer Medicine）、早期肺癌（Saito et al. Cancer Medicine）、肝細胞癌（Shiba et al. Radiation Oncology）、胆管癌（Kasuya et al. Oncotarget）、再発直腸癌（Shiba et al. Frontiers in Oncology）、リンパ節転移（Shirai et al. Frontiers in Oncology）。第二に、線量体積パラメータの最適化ならびに照射精度の向上に関する研究に取り組み、成果を発表した（Kubota et al. Radiotherapy and Oncology; Kubota et al. Cancers; Kubota et al. Anticancer Research; Kubo et al. Radiotherapy and Oncology; Kawahara et al. Journal of Radiation Research; Itabashi et al. Anticancer Research; Yokoyama et al. Frontiers in Oncology）。第三に、炭素イオン線治療の恩恵を受ける患者の層別化因子の同定を目指したトランスレーショナル研究をおこない、成果を発表した（Darwis et al. International Journal of Molecular Sciences; Yoshimoto et al. Gynecologic Oncology）。第四に、炭素イオン線の強い殺細胞効果の分子機序の解明を目指した基礎研究をおこない、成果を発表した（Permata et al. Oncogene; Kakoti et al. Oncol Rep; Anakura et al. International Journal of Molecular Sciences; Matsui et al. International Journal of Molecular Sciences; Komatsu et al. Radiotherapy and Oncology）。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Whole-bladder Radiation Therapy for Lymph Node-negative Bladder Cancer With Muscle Invasion in Elderly Patients (2020)
  • Author(s): Adachi A, Kawamura H, Yoshida D, Kawahara M, Kudo S, Ebara T, Nakano T.
  • Journal Title: Anticancer Res Volume: 40(5) Pages: 2905-2909
  • DOI: 10.21873/anticanres.14267
  • Peer Reviewed / Open Access
• [Journal Article] Use of a Si/CdTe Compton Camera for In vivo Real-Time Monitoring of Annihilation Gamma Rays Generated by Carbon Ion Beam Irradiation (2020)
  • Author(s): Shiba S, Parajuli RK, Sakai M, Oike T, Ohno T, Nakano T.
  • Journal Title: Front Oncol Volume: 19;10 Pages: 635
  • DOI: 10.3389/fonc.2020.00635
  • Peer Reviewed / Open Access
• [Journal Article] Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment (2020)
  • Author(s): Sato H, Okonogi N, Nakano T.
  • Journal Title: Int J Clin Oncol Volume: 25(5) Pages: 801-809
  • DOI: 10.1007/s10147-020-01666-1
  • Peer Reviewed / Open Access
• [Journal Article] Preliminary survey of 3D image-guided brachytherapy for cervical cancer at representative hospitals in Asian countries (2020)
  • Author(s): Okonogi N, Wakatsuki M, Mizuno H, Fukuda S, Cao J, Kodrat H, Lau FN, Calaguas MJ, de Los Reyes RH, Chansilpa Y, Uddin AFMK, Adylkhanov T, Cho CK, Tsegmed U, Hoang NC, Ohno T, Nakano T, Kato S; Forum for Nuclear Cooperation in Asia.
  • Journal Title: J Radiat Res Volume: 6;61(4) Pages: 608-615
  • DOI: 10.1093/jrr/rraa025.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Patterns of Care and Outcome Analysis of Nasopharyngeal Carcinoma: An Indonesian Single Institution Study (2020)
  • Author(s): Faisal HH, Kubo N, Nuryadi E, Prihartono J, Atmakusuma TD, Rachmadi L, Oike T, Nakano T, Gondhowiardjo SA, Adham M.
  • Journal Title: Asian Pac J Cancer Prev Volume: 1;21(5) Pages: 1481-1485.
  • DOI: 10.31557/APJCP.2020.21.5.1481
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of Inter-fractional Anatomical Changes on Dose Distributions in Passive Carbon-Ion Radiotherapy for Prostate Cancer: Comparison of Vertical and Horizontal Fields (2020)
  • Author(s): Yokoyama A, Kubota Y, Kawamura H, Miyasaka Y, Kubo N, Sato H, Abe S, Tsuda K, Sutou T, Ohno T, Nakano T.
  • Journal Title: Front Oncol Volume: 28;10 Pages: 1264
  • DOI: 10.3389/fonc.2020.01264
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma (2020)
  • Author(s): Shiba S, Shibuya K, Okamoto M, Okazaki S, Komatsu S, Kubota Y, Nakano T, Ohno T.
  • Journal Title: Radiat Oncol Volume: 14;15(1) Pages: 195
  • DOI: 10.1186/s13014-020-01634-z
  • Peer Reviewed / Open Access
• [Journal Article] Clinical outcomes of definitive whole pelvic radiotherapy for clinical lymph node metastatic prostate cancer (2020)
  • Author(s): Tsuchida K, Inaba K, Kashihara T, Murakami N, Okuma K, Takahashi K, Igaki H, Nakayama Y, Maejima A, Shinoda Y, Matsui Y, Komiyama M, Fujimoto H, Ito Y, Sumi M, Nakano T, Itami J.
  • Journal Title: Cancer Med Volume: 9(18) Pages: 6629-6637
  • DOI: 10.1002/cam4.2985
  • Peer Reviewed / Open Access
• [Journal Article] Mutation profiling of uterine cervical cancer patients treated with definitive radiotherapy (2020)
  • Author(s): Yoshimoto Y, Sasaki Y, Murata K, Noda SE, Miyasaka Y, Hamamoto J, Furuya M, Hirato J, Suzuki Y, Ohno T, Tokino T, Oike T, Nakano T.
  • Journal Title: Gynecol Oncol Volume: 159(2) Pages: 546-553
  • DOI: 10.1016/j.ygyno.2020.08.020.
  • Peer Reviewed / Open Access
• [Journal Article] Differences in Linear Energy Transfer Affect Cell-killing and Radiosensitizing Effects of Spread-out Carbon-ion Beams (2020)
  • Author(s): Shiba S, Wakatsuki M, Ohno T, Nakano T.
  • Journal Title: Anticancer Res Volume: 40(10) Pages: 5497-5502
  • DOI: 10.21873/anticanres.14561
  • Peer Reviewed / Open Access
• [Journal Article] Carbon-ion radiotherapy combined with chemotherapy for head and neck mucosal melanoma: Prospective observational study (2019)
  • Author(s): Takayasu Y, Kubo N, Shino M, Nikkuni O, Ida S, Musha A, Takahashi K, Hirato J, Shirai K, Saitoh JI, Yokoo S, Chikamatsu K, Ohno T, Nakano T; Working Group on Head and Neck Tumors.
  • Journal Title: Cancer Med Volume: 8(17) Pages: 7227-7235
  • DOI: 10.1002/cam4.2614
  • Peer Reviewed / Open Access
• [Journal Article] Carbon-ion radiotherapy for cholangiocarcinoma: a multi-institutional study by and the Japan carbon-ion radiation oncology study group (J-CROS) (2019)
  • Author(s): Kasuya G, Terashima K, Shibuya K, Toyama S, Ebner DK, Tsuji H, Okimoto T, Ohno T, Shioyama Y, Nakano T, Kamada T; Japan Carbon-Ion Radiation Oncology Study Group.
  • Journal Title: Oncotarget Volume: 8;10(43) Pages: 4369-4379
  • DOI: 10.18632/oncotarget.27028
  • Peer Reviewed / Open Access
• [Journal Article] Deep learning-assisted literature mining for in vitro radiosensitivity data (2019)
  • Author(s): Komatsu S, Oike T, Komatsu Y, Kubota Y, Sakai M, Matsui T, Nuryadi E, Permata TBM, Sato H, Kawamura H, Okamoto M, Kaminuma T, Murata K, Okano N, Hirota Y, Ohno T, Saitoh JI, Shibata A, Nakano T.
  • Journal Title: Radiother Oncol. Volume: 139 Pages: 87-93
  • DOI: 10.1016/j.radonc.2019.07.003.
  • Peer Reviewed / Open Access
• [Journal Article] A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study (2019)
  • Author(s): Shiba S, Shibuya K, Katoh H, Kaminuma T, Miyazaki M, Kakizaki S, Shirabe K, Ohno T, Nakano T.
  • Journal Title: Radiat Oncol. Volume: 2;14(1) Pages: 137
  • DOI: 10.1186/s13014-019-1347-4.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Base excision repair regulates PD-L1 expression in cancer cells (2019)
  • Author(s): Permata TBM, Hagiwara Y, Sato H, Yasuhara T, Oike T, Gondhowiardjo S, Held KD, Nakano T, Shibata A.
  • Journal Title: Oncogene Volume: 38(23) Pages: 4452-4466
  • DOI: 10.1038/s41388-019-0733-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p53 deficiency augments nucleolar instability after ionizing irradiation (2019)
  • Author(s): Kakoti S, Yamauchi M, Gu W, Kato R, Yasuhara T, Hagiwara Y, Laskar S, Oike T, Sato H, Held KD, Nakano T, Shibata A.
  • Journal Title: Oncol Rep Volume: 42(6) Pages: 2293-2302
  • DOI: 10.3892/or.2019.7341.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prospective Observational Study of High-Dose Carbon-Ion Radiotherapy for Pelvic Recurrence of Rectal Cancer (GUNMA 0801) (2019)
  • Author(s): Shiba S, Okamoto M, Kiyohara H, Ohno T, Kaminuma T, Asao T, Ojima H, Shirabe K, Kuwano H, Nakano T.
  • Journal Title: Front Oncol. Volume: 31;9 Pages: 702
  • DOI: 10.3389/fonc.2019.00702.
  • Peer Reviewed / Open Access
• [Journal Article] Radiosensitivity Differences between EGFR Mutant and Wild-Type Lung Cancer Cells are Larger at Lower Doses (2019)
  • Author(s): Anakura M, Nachankar A, Kobayashi D, Amornwichet N, Hirota Y, Shibata A, Oike T, Nakano T.
  • Journal Title: Int J Mol Sci. Volume: 25;20(15) Pages: 3635
  • DOI: 10.3390/ijms20153635.
  • Peer Reviewed / Open Access
• [Journal Article] Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity (2019)
  • Author(s): Matsui T, Nuryadi E, Komatsu S, Hirota Y, Shibata A, Oike T, Nakano T.
  • Journal Title: Int J Mol Sci. Volume: 25;20(17) Pages: 4148
  • DOI: 10.3390/ijms20174148.
  • Peer Reviewed / Open Access
• [Journal Article] Hypofractionated Intensity-modulated Radiotherapy for Intermediate- and High-risk Prostate Cancer: A Retrospective Study (2019)
  • Author(s): Kubo N, Kawamura H, Oike T, Sato H, Iwanaga M, Mizukami T, Adachi A, Matsui H, Ito K, Suzuki K, Nakano T.
  • Journal Title: In Vivo Volume: 33(4) Pages: 1235-1241
  • DOI: 10.21873/invivo.11595
  • Peer Reviewed / Open Access
• [Journal Article] FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy (2019)
  • Author(s): Darwis NDM, Nachankar A, Sasaki Y, Matsui T, Noda SE, Murata K, Tamaki T, Ando K, Okonogi N, Shiba S, Irie D, Kaminuma T, Kumazawa T, Anakura M, Yamashita S, Hirakawa T, Kakoti S, Hirota Y, Tokino T, Iwase A, Ohno T, Shibata A, Oike T, Nakano T.
  • Journal Title: Int J Mol Sci Volume: 14;20(18) Pages: 4563
  • DOI: 10.3390/ijms20184563
  • Peer Reviewed / Open Access
• [Journal Article] Dosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma (2019)
  • Author(s): Kubo N, Kubota Y, Kawamura H, Oike T, Sakai M, Kumazawa T, Miyasaka Y, Okazaki S, Kobayashi D, Sato H, Mizukami T, Musha A, Shirai K, Saitoh JI, Yokoo S, Chikamatsu K, Ohno T, Nakano T.
  • Journal Title: Radiother Oncol Volume: 141 Pages: 72-77
  • DOI: 10.1016/j.radonc.2019.07.022
  • Peer Reviewed / Open Access
• [Journal Article] Dose-volume parameters and local tumor control in cervical cancer treated with central-shielding external-beam radiotherapy and CT-based image-guided brachytherapy (2019)
  • Author(s): Okazaki S, Murata K, Noda SE, Kumazaki Y, Hirai R, Igari M, Abe T, Komatsu S, Nakano T, Kato S.
  • Journal Title: J Radiat Res Volume: 1;60(4) Pages: 490-500
  • DOI: 10.1093/jrr/rrz023
  • Peer Reviewed / Open Access
• [Journal Article] Carbon-ion radiotherapy for lymph node oligo-recurrence: a multi-institutional study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) (2019)
  • Author(s): Okonogi N, Kaminuma T, Okimoto T, Shinoto M, Yamamoto N, Yamada S, Murata K, Ohno T, Shioyama Y, Tsuji H, Nakano T, Kamada T.
  • Journal Title: Int J Clin Oncol. Volume: 24(9) Pages: 1143-1150
  • DOI: 10.1007/s10147-019-01440-y
  • Peer Reviewed / Open Access
• [Journal Article] MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment (2019)
  • Author(s): Kawahara M, Kawamura H, Kubota Y, Katoh H, Kubo N, Shimada H, Torikai K, Torikoshi M, Kanai T, Nakano T.
  • Journal Title: J Radiat Res Volume: 1;60(3) Pages: 335-341
  • DOI: 10.1093/jrr/rry111
  • Peer Reviewed / Open Access
• [Journal Article] Impact of CT-based brachytherapy in elderly patients with cervical cancer (2019)
  • Author(s): Kobayashi D, Okonogi N, Wakatsuki M, Miyasaka Y, Kiyohara H, Ohno T, Kato S, Nakano T, Kamada T.
  • Journal Title: Brachytherapy Volume: 18(6) Pages: 771-779
  • DOI: 10.1016/j.brachy.2019.08.002
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma (2019)
  • Author(s): Murata H, Okonogi N, Wakatsuki M, Kato S, Kiyohara H, Karasawa K, Ohno T, Nakano T, Kamada T, Shozu M, The Working Group Of Gynecological Tumors TWGOG.
  • Journal Title: Cancers (Basel) Volume: 4;11(4) Pages: 482
  • DOI: 10.3390/cancers11040482
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Feasibility of Salvage Re-Irradiation with CyberKnife for In-Field Neck Lymph Node Recurrence: A Retrospective Study (2019)
  • Author(s): Kobayashi D, Sato H, Saitoh JI, Oike T, Nakajima A, Noda SE, Kato S, Iwanaga M, Shimizu T, Nakano T.
  • Journal Title: J Clin Med Volume: 7;8(11) Pages: 1911
  • DOI: 10.3390/jcm8111911
  • Peer Reviewed / Open Access
• [Journal Article] Hypofractionated carbon-ion radiotherapy for stage I peripheral nonsmall cell lung cancer (GUNMA0701): Prospective phase II study (2019)
  • Author(s): Saitoh JI, Shirai K, Mizukami T, Abe T, Ebara T, Ohno T, Minato K, Saito R, Yamada M, Nakano T.
  • Journal Title: Cancer Med Volume: 8(15) Pages: 6644-6650
  • DOI: 10.1002/cam4.2561
  • Peer Reviewed / Open Access
• [Journal Article] Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer (2019)
  • Author(s): Kubota Y, Ohno T, Kawashima M, Murata K, Okonogi N, Noda SE, Tsuda K, Sakai M, Tashiro M, Nakano T.
  • Journal Title: Anticancer Res Volume: 39(4) Pages: 1915-1921
  • DOI: 10.21873/anticanres.13300
  • Peer Reviewed / Open Access
• [Journal Article] Carbon-ion Radiotherapy for Isolated Lymph Node Metastasis After Surgery or Radiotherapy for Lung Cancer (2019)
  • Author(s): Shirai K, Kubota Y, Ohno T, Saitoh JI, Abe T, Mizukami T, Mori Y, Kawamura H, Akahane K, Nakano T.
  • Journal Title: Front Oncol Volume: 7;9: Pages: 731
  • DOI: 10.3389/fonc.2019.00731
  • Peer Reviewed / Open Access
• [Journal Article] Multi-institutional Observational Study of Prophylactic Extended-Field Concurrent Chemoradiation Therapy Using Weekly Cisplatin for Patients With Pelvic Node-Positive Cervical Cancer in East and Southeast Asia (2019)
  • Author(s): Wakatsuki M, Kato S, Ohno T, Banu PA, Hoang NC, Yadamsuren E, Supriana N, Cao J, Devi CRB, Calaguas MJ, Chansilpa Y, Cho CK, Adylkhanov T, Okonogi N, Nakano T, Tsujii H.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 1;105(1) Pages: 183-189
  • DOI: 10.1016/j.ijrobp.2019.04.039
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic significance of semi-quantitative FDG-PET parameters in stage I non-small cell lung cancer treated with carbon-ion radiotherapy (2019)
  • Author(s): Shrestha S, Higuchi T, Shirai K, Tokue A, Shrestha S, Saitoh JI, Hirasawa H, Ohno T, Nakano T, Tsushima Y.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 47(5) Pages: 1220-1227
  • DOI: 10.1007/s00259-019-04585-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity (2019)
  • Author(s): Ikawa H, Koto M, Demizu Y, Saitoh JI, Suefuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Hayashi K, Nemoto K, Nakano T, Kamada T.
  • Journal Title: Cancer Med Volume: 8(12) Pages: 5482-5491
  • DOI: 10.1002/cam4.2408
  • Peer Reviewed / Open Access
• [Journal Article] Comparison between bone matching and marker matching for evaluation of intra- and inter-fractional changes in accumulated dose of carbon ion radiotherapy for hepatocellular carcinoma (2019)
  • Author(s): Kubota Y, Katoh H, Shibuya K, Shiba S, Abe S, Sakai M, Yuasa D, Tsuda K, Ohno T, Nakano T.
  • Journal Title: Radiother Oncol Volume: 137 Pages: 77-82
  • DOI: 10.1016/j.radonc.2019.04.026
  • Peer Reviewed / Open Access
• [Journal Article] Compton imaging with (99m)Tc for human imaging (2019)
  • Author(s): Sakai M, Kubota Y, Parajuli RK, Kikuchi M, Arakawa K, Nakano T.
  • Journal Title: Sci Rep Volume: 9;9(1) Pages: 12906
  • DOI: 10.1038/s41598-019-49130-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Divided-volume matching technique for volume displacement estimation of patient positioning in radiation therapy (2019)
  • Author(s): Tashiro M, Kubota Y, Torikoshi M, Ohno T, Nakano T.
  • Journal Title: Phys Med. Volume: 62 Pages: 1-12
  • DOI: 10.1016/j.ejmp.2019.04.028
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients (2019)
  • Author(s): Kubota Y, Okamoto M, Li Y, Shiba S, Okazaki S, Komatsu S, Sakai M, Kubo N, Ohno T, Nakano T.
  • Journal Title: Cancers (Basel) Volume: 27;11(10) Pages: 1447
  • DOI: 10.3390/cancers11101447
  • Peer Reviewed / Open Access
• [Journal Article] Potential Pitfalls of Diaphragm Structural Matching in Carbon-ion Radiotherapy for Pancreatic Cancer (2019)
  • Author(s): Itabashi Y, Kubota Y, Okamoto M, Tsuda K, Shiba S, Hoshino Y, Suto T, Ohno T, Nakano T.
  • Journal Title: Anticancer Res Volume: 39(8) Pages: 4351-4356
  • DOI: 10.21873/anticanres.13603.
  • Peer Reviewed / Open Access
• [Journal Article] X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity (2019)
  • Author(s): Puspitasari A, Yamazaki H, Kawamura H, Nakano T, Takahashi A, Shirao T, Held KD.
  • Journal Title: Neurosci Res Volume: S0168-0102(19) Pages: 30320-7
  • DOI: 10.1016/j.neures.2019.11.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Phase 1/2 Study of Carbon Ion Radiation Therapy With Concurrent Chemotherapy for Locally Advanced Uterine Cervical Squamous Cell Carcinoma (Protocol 1302) (2019)
  • Author(s): Okonogi N, Wakatsuki M, Kato S, Karasawa K, Miyasaka Y, Murata H, Nakano T, Kamada T, Shozu M; Working Group of Gynecological Tumors.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 1;104(3) Pages: 631-639
  • DOI: 10.1016/j.ijrobp.2019.02.042
  • Peer Reviewed / Open Access
• [Journal Article] Postoperative pelvic intensity-modulated radiation therapy reduced the incidence of late gastrointestinal complications for uterine cervical cancer patients (2019)
  • Author(s): Tsuchida K, Murakami N, Kato T, Okuma K, Okamoto H, Kashihara T, Takahashi K, Inaba K, Igaki H, Nakayama Y, Nakano T, Itami J.
  • Journal Title: J Radiat Res Volume: 23;60(5) Pages: 650-657
  • DOI: 10.1093/jrr/rrz041
  • Peer Reviewed / Open Access
• [Presentation] Regulation of DNA damage signal-dependent PD-L1 upregulation in cancer cells after ionizingirradiation (2020)
  • Author(s): H. Sato, T. B. M. Permata, W. Gu, S. Kakoti, T. Oike, T. Yasuhara, T. Nakano, T. Ohno, and A. Shibata
  • Organizer: 2020 Astro Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] HIMACから量子メスへ 量子メスマイクロサージェリー化プロジェクト 日本未来医療を見据えたQSTの新たなる挑戦と展望 (2020)
  • Author(s): 中野 隆史
  • Organizer: 第29回日本定位放射線学会
  • Invited
• [Presentation] A preliminary study on adaptive carbon-ion radiotherapy with passive irradiation for pancreatic cancer. (2019)
  • Author(s): Y Li, Y Kubota, M Okamoto, S Shiba, S Okazaki, S Komatsu, T Nakano, T Ohno.
  • Organizer: PTCOG-AO2019
  • Int'l Joint Research
• [Presentation] Evaluation of intensity-, contour-based, and hybrid deformable image registration accuracy for pancreatic cancer patient images. (2019)
  • Author(s): Y Kubota, M Okamoto, Y Li, S Shiba, S Okazaki, S Komatsu, M Sakai, N Kubo, T Ohno, T Nakano
  • Organizer: PTCOG-AO2019
  • Int'l Joint Research
• [Presentation] Analysis of inter-study precision of in vitro radiosensitivity data (2019)
  • Author(s): Toshiaki Matsui1 Takahiro Oike1, Endang Nuryadi2, Tiara Bunga Mayang Permata2, Takashi Nakano1
  • Organizer: FARO Meeting 2019
  • Int'l Joint Research
• [Presentation] Carobon ion radiotheraphy for born and soft tissue tumors:analysis of 92 patients at Gunma University Heavyion Medical center(GHMC) (2019)
  • Author(s): T. Kaminuma, M. Okamoto, H. Kiyohara, T. Yanagawa, K. Shibuya, N. Okano, S. Shiba, Y. Mori, K. I. Saitoh, T. Nozaki, T. Ohno and T. Nakano
  • Organizer: 2019 ASTRO Annual Meeting
  • Int'l Joint Research
• [Presentation] Inter-Study Precision of Cancer Cell Radiosensitivity As Assessed By Colony Formation Assay (2019)
  • Author(s): Toshiaki Matsui, Takahiro Oike, Endang Nuryadi, Takashi Nakano
  • Organizer: 2019 ASTRO Annual Meeting
  • Int'l Joint Research
• [Presentation] Analysis of nucleolus stability after ionizing irradiation. (2019)
  • Author(s): Sangeeta Kakoti, Yoshihiko Hagiwara, Motohiro Yamauchi, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and Atsushi Shibata
  • Organizer: ICRR2019
  • Int'l Joint Research / Invited
• [Presentation] Initial results of carbon ion radiotherapy combined with S-1 for locally advanced pancreatic cancer (2019)
  • Author(s): Yasumasa Mori1,2, Masahiko Okamoto1,2, Hiroki Kiyohara３,Hiroyuki Katoh4,Kei Shibuya1,2, Takuya Kaminuma1,2, Shintaro Shiba1,2 ,Naoko Okano1,2, Tatsuya
  • Organizer: ESTRO38
  • Int'l Joint Research
• [Presentation] 放射線治療に魅せられた温故知新 (2019)
  • Author(s): 中野 隆史
  • Organizer: 放射線治療談話会第三回例会
  • Invited
• [Presentation] Improvement of reconstruction algorithm for Compton camera (2019)
  • Author(s): M sakai, R K Parajuli, Y Kubota, N Kikuchi, K Arakawa, and T Nakano
  • Organizer: 2019 IEEE Nuclear Science Symposium & Medical Imaging Conference
  • Int'l Joint Research