Analysis of cleft palate mechanism using p53 gene-deficient consomic mice

2019 Fiscal Year Final Research Report

• Project/Area Number: 16H05539
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: Takagi Ritsuo 新潟大学, 医歯学系, 教授 (20143795)
• Co-Investigator(Kenkyū-buntansha): 大峡 淳 新潟大学, 医歯学系, 教授 (40266169) ; 児玉 泰光 新潟大学, 医歯学総合病院, 講師 (90419276)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 口蓋裂 / p53

Outline of Final Research Achievements

CL / Fr strain mice, which are inbred mice, include mice having both a primary cleft palate and a secondary cleft palate. This time, using CL / Fr strain mice, we analyzed whether there is a difference at the molecular level between primary cleft palate and secondary cleft palate. No change was observed in those signals in the secondary cleft palate region.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

口蓋裂は、一次口蓋と二次口蓋の間の口蓋裂 (primary cleft palate)と、二次口蓋における口蓋裂(secondary cleft palate)に大別され、primary cleft palateとsecondary cleft palateが同じメカニズムで生じているかは不明である。本研究の結果から、primary cleft palateとsecondary cleft palateは、別々のメカニズムでひき起こる可能性があることが示唆された。