2018 Fiscal Year Annual Research Report
Effects and Safety of Oral Mast Cells Stabilization Therapy in Early Dengue Patients: A Randomized, Placebo-Controlled Trial
| Project/Area Number |
16H05844
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| Research Institution | Nagasaki University |
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Principal Investigator |
グエン フイティエン 長崎大学, 熱帯医学・グローバルヘルス研究科, 准教授 (20457526)
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| Co-Investigator(Kenkyū-buntansha) |
ローサボーン チャントラ 長崎大学, 熱帯医学研究所, 教授 (10640196)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Dengue / Clinical trial / Ultrasound / Mast cells / Allergy / Severity |
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| Outline of Annual Research Achievements |
Our systematic review provided a standardized ultrasound to measure the plasma leakage in dengue patients that is the main indicator of dengue severity. A clinical study has been conducted to assess the reproducibility of US in the assessment of gallbladder-wall thickness in addition to the volume of pleural effusion and ascites as a consequence of plasma leakage in dengue children.
We assessed the presence of pleural effusions, ascites and gallbladder wall edema, which are the main signs of plasma leakage. In addition, we will look for other common signs of dengue hemorrhagic fever, such as hepatomegaly, splenomegaly, hepatic subcapsular fluid, perirenal and retroperitoneal edema. The normal gallbladder should have a hyperechoic, thin wall and contain anechoic bile. Measure the wall thickness in a longitudinal section of the gallbladder, with the calipers perpendicular to the wall itself. (A transverse section may not be perpendicular to the wall and can overestimate the thickness). The thickness of anterior wall is measured at its most narrow part. Gallbladder wall edema is considered in cases where the gallbladder wall thickness is > 3.0 mm. Our results showed that ultrasound values of plasma leakage were highly reproducible and showed a good intra- and inter-observer agreement between ultrasonic doctors. In addition, anti-histamine significantly lower the degree of plasma leakage.
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| Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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Research Products
(5 results)
