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2018 Fiscal Year Annual Research Report

Effects and Safety of Oral Mast Cells Stabilization Therapy in Early Dengue Patients: A Randomized, Placebo-Controlled Trial

Research Project

Project/Area Number 16H05844
Research InstitutionNagasaki University

Principal Investigator

グエン フイティエン  長崎大学, 熱帯医学・グローバルヘルス研究科, 准教授 (20457526)

Co-Investigator(Kenkyū-buntansha) ローサボーン チャントラ  長崎大学, 熱帯医学研究所, 教授 (10640196)
Project Period (FY) 2016-04-01 – 2019-03-31
KeywordsDengue / Clinical trial / Ultrasound / Mast cells / Allergy / Severity
Outline of Annual Research Achievements

Our systematic review provided a standardized ultrasound to measure the plasma leakage in dengue patients that is the main indicator of dengue severity. A clinical study has been conducted to assess the reproducibility of US in the assessment of gallbladder-wall thickness in addition to the volume of pleural effusion and ascites as a consequence of plasma leakage in dengue children.
We assessed the presence of pleural effusions, ascites and gallbladder wall edema, which are the main signs of plasma leakage. In addition, we will look for other common signs of dengue hemorrhagic fever, such as hepatomegaly, splenomegaly, hepatic subcapsular fluid, perirenal and retroperitoneal edema. The normal gallbladder should have a hyperechoic, thin wall and contain anechoic bile. Measure the wall thickness in a longitudinal section of the gallbladder, with the calipers perpendicular to the wall itself. (A transverse section may not be perpendicular to the wall and can overestimate the thickness). The thickness of anterior wall is measured at its most narrow part. Gallbladder wall edema is considered in cases where the gallbladder wall thickness is > 3.0 mm. Our results showed that ultrasound values of plasma leakage were highly reproducible and showed a good intra- and inter-observer agreement between ultrasonic doctors. In addition, anti-histamine significantly lower the degree of plasma leakage.

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

  • Research Products

    (5 results)

All 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 5 results)

  • [Journal Article] Systematic review of spontaneous splenic rupture in dengue-infected patients2019

    • Author(s)
      Radwan Ibrahim、Magdy Khattab Mohamed、Mahmoud Abdalla Reda、Nghia Thai Le Ba、Y Mai Nhu、Trung Dinh The、Hirayama Kenji、Huy Nguyen Tien
    • Journal Title

      Reviews in Medical Virology

      Volume: 29 Pages: e2029~e2029

    • DOI

      10.1002/rmv.2029

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue2019

    • Author(s)
      Phuong Nguyen Thi Ngoc、Manh Dao Huy、Dumre Shyam Prakash、Mizukami Shusaku、Weiss Lan Nguyen、Van Thuong Nguyen、Ha Tran Thi Ngoc、Phuc Le Hong、Van An Tran、Tieu Thuan Minh、Kamel Mohamed Gomaa、Morra Mostafa Ebraheem、Huong Vu Thi Que、Huy Nguyen Tien、Hirayama Kenji
    • Journal Title

      Annals of Clinical Microbiology and Antimicrobials

      Volume: 18 Pages: 1~6

    • DOI

      10.1186/s12941-019-0309-x

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Definitions for warning signs and signs of severe dengue according to the WHO 2009 classification: Systematic review of literature2018

    • Author(s)
      Morra Mostafa Ebraheem、Altibi Ahmed M.A.、Iqtadar Somia、Minh Le Huu Nhat、Elawady Sameh Samir、Hallab Asma、Elshafay Abdelrahman、Omer Omer Abedlbagi、Iraqi Ahmed、Adhikari Purushottam、Labib Jonair Hussein、Elhusseiny Khaled Mosaad、Elgebaly Ahmed、Yacoub Sophie、Huong Le Thi Minh、Hirayama Kenji、Huy Nguyen Tien
    • Journal Title

      Reviews in Medical Virology

      Volume: 28 Pages: e1979~e1979

    • DOI

      10.1002/rmv.1979

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between dengue severity and plasma levels of dengue-specific IgE and chymase2018

    • Author(s)
      Inokuchi Miho、Dumre Shyam Prakash、Mizukami Shusaku、Tun Mya Myat Ngwe、Kamel Mohamed Gomaa、Manh Dao Huy、Phuc Le Hong、Van Thuong Nguyen、Van An Tran、Weiss Lan Nguyen、Turk Tarek、Dang Tran Ngoc、Huong Vu Thi Que、Morita Kouichi、Huy Nguyen Tien、Hirayama Kenji
    • Journal Title

      Archives of Virology

      Volume: 163 Pages: 2337~2347

    • DOI

      10.1007/s00705-018-3849-z

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dengue hemophagocytic syndrome: A systematic review and meta‐analysis on epidemiology, clinical signs, outcomes, and risk factors2018

    • Author(s)
      Giang Hoang Thi Nam、Banno Keita、Minh Le Huu Nhat、Trinh Lam Tuyet、Loc Le Thai、Eltobgy Asmaa、Tai Luu Lam Thang、Khan Adnan、Tuan Nguyen Hoang、Reda Yaser、Samsom Maryan、Nam Nguyen Tran、Huy Nguyen Tien、Hirayama Kenji
    • Journal Title

      Reviews in Medical Virology

      Volume: 28 Pages: e2005~e2005

    • DOI

      10.1002/rmv.2005

    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2019-12-27  

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