先端モデル動物支援プラットフォーム

2016 Fiscal Year Annual Research Report

• Project/Area Number: 16H06276
• Research Institution: The University of Tokyo
• Principal Investigator: 今井 浩三 東京大学, 医科学研究所, 客員教授 (60117603)
• Co-Investigator(Kenkyū-buntansha): 中村 卓郎 公益財団法人がん研究会, がん研究所, 副所長 (00180373) ; 井上 純一郎 東京大学, 医科学研究所, 教授 (70176428) ; 高田 昌彦 京都大学, 霊長類研究所, 教授 (00236233) ; 吉田 進昭 東京大学, 医科学研究所, 教授 (10250341) ; 高橋 智 筑波大学, 医学医療系, 教授 (50271896) ; 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066) ; 﨑村 建司 新潟大学, 脳研究所, 教授 (40162325) ; 荒木 喜美 熊本大学, 生命資源研究・支援センター, 教授 (90211705) ; 八尾 良司 公益財団法人がん研究会, がん研究所, 主任研究員 (80291095) ; 真下 知士 大阪大学, 大学院医学系研究科, 准教授 (80397554) ; 小林 和人 福島県立医科大学, 医学部, 教授 (90211903) ; 豊國 伸哉 名古屋大学, 大学院医学系研究科, 教授 (90252460) ; 鰐渕 英機 大阪市立大学, 大学院医学研究科, 教授 (90220970) ; 今井田 克己 香川大学, 医学部, 教授 (90160043) ; 二口 充 名古屋市立大学, 大学院医学研究科, 准教授 (60275120) ; 上野 正樹 香川大学, 医学部, 教授 (30322267) ; 宮崎 龍彦 岐阜大学, 医学部附属病院, 准教授 (80239384) ; 神田 浩明 公益財団法人がん研究会, がん研究所, 主任研究員 (90260067) ; 尾藤 晴彦 東京大学, 大学院医学系研究科, 教授 (00291964) ; 宮川 剛 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780) ; 高雄 啓三 富山大学, 研究推進機構・研究推進総合支援センター, 教授 (80420397) ; 池田 和隆 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656) ; 虫明 元 東北大学, 大学院医学系研究科, 教授 (80219849) ; 清宮 啓之 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 部長 (50280623) ; 長田 裕之 国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836) ; 旦 慎吾 公益財団法人がん研究会, がん化学療法センター・分子薬理部, 副部長 (70332202) ; 井本 正哉 慶應義塾大学, 理工学部, 教授 (60213253) ; 川田 学 公益財団法人微生物化学研究会, 微生物化学研究所・第1生物活性研究部, 部長 (20300808) ; 田原 栄俊 広島大学, 大学院医歯薬保健学研究科(薬), 教授 (00271065) ; 吉田 稔 国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617) ; 松浦 正明 帝京大学, 大学院公衆衛生学研究科, 教授 (40173794) ; 牛嶋 大 公益財団法人がん研究会, 有明病院・臨床研究・開発センター, 研究員 (60328565)
• Project Period (FY): 2016 – 2021
• Keywords: モデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子探索・ブロファイリング

Outline of Annual Research Achievements

①総括支援活動 : ホームページ(HP)を立ち上げ広報活動を推進し、公募を一元化した。モデル動物作製解析の講習や若手研究者の交流促進を推進する技術講習会を開催した。成果ワークショップを開催し、本活動の支援成果をアピールした。支援に関する今後の部分的な実費徴収について、規程作成準備会議を7回開催して準備を進めている。
②モデル動物作製支援活動 : 相同組換えやゲノム編集など支援課題に応じた最適な胚操作技術を用いて、様々な遺伝子改変マウスおよびラットを的確かつ迅速に作製し、学術性の高い個体レベルの研究推進に資する研究リソースとして提供した。
③病理形態解析支援活動 : 全国の18の施設から23件の支援を行った。動物解剖から病理標本の作製、免疫染色、論文投稿用のデジタル画像の撮影など、多数の支援を施行した。いずれの支援に関しても研究を推進する上で重要なものであった。
④生理機能解析支援活動 : CHD8遺伝子改変マウスの自閉症様行動異常の解析支援を実施(Nature 2016)し、諸動物モデルでの規制薬物感受性解析、光遺伝学的in vivo細胞操作、意志決定に関与する脳深部機能解析、等の支援を展開した。
⑤分子ブロファイリング支援活動 : 依頼化合物の分子プロファイリング196件、阻害剤キット配付80枚、RNA干渉キット配付・siRNAデザイン合成122件、バーコードshRNAライブラリーによる化合物の標的経路探索1件、を実施した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : HPの立ち上げは順調に行われた。技術講習会と成果発表会も多くの参加者を得て好評裡に開催することができた。HPを利用した公募システムについて修正すべき点が指摘されたが、改修が行われ次年度はより円滑な公募と課題管理が行われる予定である。
②モデル動物作製支援活動 : 初年度にあたり、支援課題の公募、採択の遅延により、作業の開始にやや遅れが生じた。
③病理形態解析支援活動 : 全国の18の施設から23件の支援を行った。年間を通して申し込みがあり、目的を順調に達成していると考える。
④生理機能解析支援活動 : 生理機能解析支援拠点としては、当初設定した支援件数を概ね達成し、着実に支援が進展している。
⑤分子ブロファイリング支援活動 : 支援内容の性質上、萌芽的な課題であっても最大限に採択する方針を貫き、フル稼働で支援を実施した。初年度であったため、被験化合物の情報管理・集配体制の構築、支援担当者間の連絡・連携体制の確立に多くの時間を費やした。

Strategy for Future Research Activity

①総括支援活動 : HPを利用した広報は順調に進んでいるので、公募システムを一層使い易くする。技術講習会では生命科学連携推進協議会の他のプラットフォームとの連携を推進し、平成29年度はバイオイメージングから参加者を受け入れる。
②モデル動物作製支援活動 : 予算限度を越える応募があり、採択することができる支援課題数に限りがあった。今後は、さらに先端的なゲノム編集技術を積極的に導入・開発することにより効率化と迅速化による支援活動の拡充を図る。
③病理形態解析支援活動 : 今後も引き続き、研究者からの幅広い要求に対応していくと同時に、最終的に支援者の論文が受理されるまでサポートを継続する方策である。件数が増えて予算上の問題が起こってきたときには審査基準を厳しくすることで対応する。
④生理機能解析支援活動 : 平成28年度に開始した支援方針を堅持するとともに、一層多くの被支援研究者からの要望に応えられるよう、支援技術の維持・向上に務める。
⑤分子プロファイリング支援活動 : 今後の推進方策 : 広報活動の強化により被支援者層の拡大を図るとともに、支援実施後も適宜、科学的助言や共同研究斡旋などのフォローを行う。年2回の班会議で問題点を洗い出し、運用体制の最適化を継続する。

Research Products

• [Int'l Joint Research] ベイラー医科大学(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: ベイラー医科大学
• [Int'l Joint Research] Harvard Medical School, Boston(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Harvard Medical School, Boston
• [Int'l Joint Research] スタンフォード大学/エール大学(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: スタンフォード大学/エール大学
• [Int'l Joint Research] 南通大学(中国)
  • Country Name: CHINA
  • Counterpart Institution: 南通大学
• [Journal Article] Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer. (2017)
  • Author(s): Taniguchi H, Hoshino D, Moriya C, Zembutsu H, Nishiyama N, Yamamoto H, Kataoka K, Imai K.
  • Journal Title: Oncotarget Volume: 8 Issue: 29 Pages: 46856-46874
  • DOI: 10.18632/oncotarget
  • Peer Reviewed / Open Access
• [Journal Article] HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma. (2017)
  • Author(s): Tsuji S, Washimi K, Kageyama T, Yamashita M, Matsuura R, Yokose T, Kamada Y, Hayashi H, Morohoshi T, Tsuura Y, Yusa T, Sato T, Togayachi A, Narimatsu H, Nagasaki T, Nakamoto K, Moriwaki Y, Misawa H, Hiroshima K, Miyagi Y, Imai K.
  • Journal Title: Scientific Reports Volume: 7 Pages: 45768
  • DOI: 10.1038/srep45768.
  • Peer Reviewed / Open Access
• [Journal Article] New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. (2017)
  • Author(s): Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M.
  • Journal Title: FASEB J.
  • DOI: 10.1096/fj.201600642R
  • Peer Reviewed / Open Access
• [Journal Article] The mechanics clarifying counterclockwise rotation in most IVF eggs in mice. (2017)
  • Author(s): Ishimoto K, Ikawa M, Okabe M.
  • Journal Title: Sci Rep. Volume: 7 Pages: 43456
  • DOI: 10.1038/arep43456
  • Peer Reviewed / Open Access
• [Journal Article] SHISA6 confers resistance to differentiation-promoting Wnt/6-catenin aignaling in mouse spermatogenic stem cells. (2017)
  • Author(s): Tokue M, Jkami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.
  • Journal Title: Stem Cell Report Volume: S2213-6711 Pages: 30021-8
  • DOI: 10.1016/j.stemcr.2017.01.006.
  • Peer Reviewed
• [Journal Article] Pharmacological targeting of plasmin prevents lethality in a murine mode of macrophage activation syndrome. (2017)
  • Author(s): Shimazu H, Munakata S, Tashiro Y, Salama Y, Dhahri D, Eiamboonsert S, Ota Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
  • Journal Title: Blood
  • DOI: 10.1182/blood-2016-09-738096.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia (2017)
  • Author(s): Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H
  • Journal Title: Sci Rep. Volume: 7 Pages: 45050
  • DOI: 10.1038/srep45050
  • Peer Reviewed / Open Access
• [Journal Article] Loss of NDRG2 expression confers oral squamous cell carcinoma with enhanced metastatic potential (2017)
  • Author(s): T. Tamura, T. Ichikawa, S. Nakahata, Y. Kondo, Y. Tagawa, K. Yamamoto, K. Nagai, T. Baba, R. Yamaguchi, M. Futakuchi, Y. Yamashita, K. Morishita
  • Journal Title: Cancer Res
  • DOI: 10.1158/0008-5472.CAN-16-2114
  • Peer Reviewed / Open Access
• [Journal Article] A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo (2017)
  • Author(s): M. Kawada, H. Inoue, M. Kajikawa, M. Sugiura, S. Sakamoto, S. Urano, C. Karasawa, I. Usami, M. Futakuchi, T. Masuda.
  • Journal Title: Sci Rep. Volume: 7 Pages: 40400
  • DOI: 10.1038/srep40400
  • Peer Reviewed / Open Access
• [Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics. (2017)
  • Author(s): Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T.
  • Journal Title: Sci Rep.
  • Peer Reviewed / Open Access
• [Journal Article] Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor. (2017)
  • Author(s): Shikata Y, Yoshimaru T, Komatsu M, Katoh H, Sato R, Kanagaki S, Okazaki Y, Toyokuni S, Tashiro E, Ishikawa S, Katagiri T, Imoto M.
  • Journal Title: Cancer Sci
  • DOI: 10.1111/cas.13175.
  • Peer Reviewed / Open Access
• [Journal Article] Gut microbiota promotes obesity-associated liver cancer throug PGE2-mediated suppression of antitumor immunity (2017)
  • Author(s): Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N
  • Journal Title: Cancer Discovery
  • DOI: 10.1158/2159-8290.CD-16-0932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. (2017)
  • Author(s): Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K.
  • Journal Title: Exp Neurol Volume: 293 Pages: 1-12
  • DOI: 10.1016/j.expneurol.2017.03.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combination treatment with naftopidil increases the efficacy of radiotherapy in PC-3 human prostate cancer cells (2017)
  • Author(s): Iwamoto Y, Ishii K, Kanda H, Kato M, Miki M, Kajiwara S, Arima K, Shiraishi T, Sugimura Y.
  • Journal Title: J Cancer Res Clin Oncol
  • DOI: 10.1007/s00432-017-2367-9
  • Peer Reviewed
• [Journal Article] A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B (2017)
  • Author(s): Takase S, Kurokawa R, Arai D, Kanto KK, Okino T, Nakao Y, Kushiro T, Yoshida M, Matsumoto K.
  • Journal Title: Sci Rep
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Down-regulation of Forkhead Box Protein A1 (FOXA1) Leads Cancer-stem Cell-like Properties in Tamoxifen-resistant Breast Cancer Cells through Induction of Interleukin-6 (2017)
  • Author(s): Yamaguchi N, Nakayama Y, Yamaguchi N.
  • Journal Title: J Biol Chem
  • DOI: 10.1074/jbc.M116.763276.
  • Peer Reviewed / Open Access
• [Journal Article] Cancer stem cells in human gastrointestinal cancer. (2016)
  • Author(s): Taniguchi H, Moriya C, Igarashi H, Saitoh A, Yamamoto H, Adachi Y, Imai K.
  • Journal Title: Cancer Sci Volume: 107 Issue: 11 Pages: 1556-1562
  • DOI: 10.1111/cas.13069.
  • Peer Reviewed / Open Access
• [Journal Article] The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy. (2016)
  • Author(s): Matsunaga Y, Adachi Y, Sasaki Y, Koide H, Motoya M, Nosho K, Takagi H, Yamamoto H, Sasaki S, Arimura Y, Tokino T, Carbone DP, Imai K, Shinomura Y.
  • Journal Title: Mol Carcinogen Volume: 56 Issue: 2 Pages: 515-526
  • DOI: 10.1002/mc.22513.
  • Peer Reviewed / Open Access
• [Journal Article] Cancer Transitional Care for Terminally Ill Cancer Patients Can Reduce the Number of Emergency Admissions and Emergency Department Visits. (2016)
  • Author(s): Shimada N, Ishiki H, Iwase S, Chiba T, Fujiwara N, Watanabe A, Kinkawa J, Nojima M, Tojo A, Imai K.
  • Journal Title: American Journal of Hospice & Palliative Medicine.
  • DOI: 10.1177/1049909116658641.
  • Peer Reviewed
• [Journal Article] A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer. (2016)
  • Author(s): Kumegawa K, Maruyama R, Yamamoto E, Ashida M, Kitajima H, Tsuyada A, Niinuma T, Kai M, Yamano H, Sugai T, Tokino T, Shinomura Y, Imai K, Suzuki H.
  • Journal Title: Scientific Reports Volume: 6 Pages: 26699
  • DOI: 10.1038/srep26699.
  • Peer Reviewed / Open Access
• [Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway. (2016)
  • Author(s): Kurihara H, Maruyama R, Ishiguro K, Kanno S, Yamamoto I, Ishigami K, Mitsuhashi K, Igarashi H, Ito M, Tanuma T, Sukawa Y, Okita K, Hasegawa T, Imai K, Yamamoto H, Shinomura Y, Nosho K.
  • Journal Title: Oncotarget Volume: 7 Issue: 11 Pages: 12704-17
  • DOI: 10.18632/oncotarget.7260.
  • Peer Reviewed / Open Access
• [Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. (2016)
  • Author(s): Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y.
  • Journal Title: World J Gastroenterol Volume: 22 Pages: 557-66
  • DOI: 10.3748/wjg.v22.i2.557.
  • Peer Reviewed / Open Access
• [Journal Article] Seasonal allergies and serial changes of serum levels of IgG4 in cases treated with maintenance therapy for IgG4-related disease. (2016)
  • Author(s): Yamamoto M, Takahashi H, Shimizu Y, Yajima H, Suzuki C, Naishiro Y, Imai K, Shinomura Y.
  • Journal Title: Mod Rheumatol. Volume: 26 Issue: 1 Pages: 161-2
  • DOI: 10.3109/14397595.2014.995893.
  • Peer Reviewed
• [Journal Article] Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer, Second report. (2016)
  • Author(s): Goto A, Noto H, Noda M, Ueki K, Kasuga M, Tajima N, Ohashi K, Sakai R, Tsugane S, Hamajima N, Tajima K, Imai K, Nakagama H.
  • Journal Title: Cancer Science Volume: 107 Issue: 3 Pages: 369-71
  • DOI: 10.1111/cas.12889.
  • Peer Reviewed / Open Access
• [Journal Article] Fertilization defects in sperm from Cysteine-rich secretory protein 2(Crisp2) knockout mice : Implications for fertility disorders. (2016)
  • Author(s): Brukman NG, Miyata H, Torres P, Lombardo D, Caramelo JJ, Ikawa M, DaRos VG, Cuasnú PS.
  • Journal Title: Mol Hum Reprod. Volume: 22 Issue: 4 Pages: 240-51
  • DOI: 10.1093/molehr/gaw005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GPI-AP release in cellular, developmental, and reproductive biology. (2016)
  • Author(s): Fujihara Y, Ikawa M.
  • Journal Title: J Lipid Res. Volume: 57 Issue: 4 Pages: 538-545
  • DOI: 10.1194/jlr.R063032
  • Peer Reviewed / Open Access
• [Journal Article] Generation of Hprt-disrupted rat through mouse←rat ES chimeras. (2016)
  • Author(s): Isotani A, Yamagata K, Okabe M, Ikawa M.
  • Journal Title: Sci Rep. Volume: 6 Pages: 24215-24221
  • DOI: 10.1038/srep24215
  • Peer Reviewed / Open Access
• [Journal Article] The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in Mice. (2016)
  • Author(s): Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N.
  • Journal Title: Biol Reprod Volume: 94 Pages: 1-11
  • DOI: 10.1095/biolreprod.115.135988.
  • Peer Reviewed / Open Access
• [Journal Article] TARP γ-2 and γ-8 differentially control AMPAR density across Schaffer collateral/commissural synapsee in the hippocampal CA1 area. (2016)
  • Author(s): Yamasaki M, Fukaya M, Yamazaki M, Azechi H, Natsume R, Abe M, Sakimura K, Watanabe M.
  • Journal Title: J. Neurosci. Volume: 36 Pages: 4296-4312
  • DOI: 10.1523/JNEUROSCI.4178-15.2016
  • Peer Reviewed
• [Journal Article] GluD2 endows parallel fiber-Purkinje cell synapses with a high regenerative capacity (2016)
  • Author(s): Ichikawa R, Sakimura K, Watanabe M.
  • Journal Title: J. Neurosci. Volume: 36 Pages: 4846-4858
  • DOI: 10.1523/JNEUROSCI.0161-16.2016
  • Peer Reviewed
• [Journal Article] Kidney-specific knockout of Savl in the mouse promotes hyper-proliferation of renal tubular epithelium through suppression of the Hippo pathway. (2016)
  • Author(s): Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, Matsuura K, Moriyama M.
  • Journal Title: J Pathol. Volume: 239 Issue: 1 Pages: 97-108
  • DOI: 10.1002/path.4706
  • Peer Reviewed / Open Access
• [Journal Article] The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and it is essential for reproduction. (2016)
  • Author(s): Yamazaki D, Miyata H, Funato Y, Fujihara Y, Ikawa M, Miki H.
  • Journal Title: J Cell Sci. Volume: 129 Issue: 9 Pages: 1940-1949
  • DOI: 10.1242/jcs.182220
  • Peer Reviewed / Open Access
• [Journal Article] The importance of basonuclin 2 in adult mice and its relation to basonuclinl. (2016)
  • Author(s): Vanhoutteghem, A., Delhomme, B., Herve, F., Nondier, I., Petit, J. M., Araki, M., Araki, K. and Djian, P.
  • Journal Title: Mech. Dev. Volume: 140 Pages: 53-73
  • DOI: 10.1016/j.mod.2016.02.002.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. (2016)
  • Author(s): Shimbo M, Kudo T, Hamada M, Jeon H, Ikawa M, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Shiba D, Takahashi S.
  • Journal Title: Exp Anim. Volume: 65 Pages: 175-87
  • DOI: 10.1538/expanim.15-0077.
  • Peer Reviewed / Open Access
• [Journal Article] Transsynaptic modulation of kainate receptor functions by Clq-like proteins. (2016)
  • Author(s): Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M
  • Journal Title: Neuron Volume: 90 Pages: 752-767
  • DOI: 10.1016/j.neuron.2016.04.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse. (2016)
  • Author(s): Kanemori Y, Koga Y, Sudo M, Kang W, Kashiwabara SI, Ikawa M, Hasuwa H, Nagashima K, Ishikawa Y, Ogonuki N, Ogura A, Baba T.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 113 Pages: E3696-705
  • DOI: 10.1073/pnas.1522333113
  • Peer Reviewed / Open Access
• [Journal Article] Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout micegenerated using a one-step CRISPR/Cas9 system. (2016)
  • Author(s): Nakagawa Y, Oikawa F, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Song-iee H, Mizuno S, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H.
  • Journal Title: Scientific Report Volume: 6 Pages: 27857
  • DOI: 10.1038/srep27857.
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant PD-L1 expression via 3'-UTR disruption in multiple cancers. (2016)
  • Author(s): Kataoka K, et al.
  • Journal Title: Nature Volume: 534 Issue: 7607 Pages: 402-6
  • DOI: 10.1038/nature18294.
  • Peer Reviewed
• [Journal Article] Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. (2016)
  • Author(s): Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis R, Satouh Y, Zhang Q, Ikawa M, Matzuk MM.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 113 Issue: 28 Pages: 7704-7710
  • DOI: 10.1073/pnas.1608458113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. (2016)
  • Author(s): Shimada M, Goshima T, Matsuo H, Johmura Y, Haruta M, Murata K, Tanaka H, Ikawa M, Nakanishi K, Nakanishi M.
  • Journal Title: Nat Commun. Volume: 7 Pages: 12059
  • DOI: 10.1038/ncomms12059
  • Peer Reviewed / Open Access
• [Journal Article] Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization. (2016)
  • Author(s): Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O.
  • Journal Title: Nat Commun. Volume: 7 Pages: 12198
  • DOI: 10.1038/ncomms12198
  • Peer Reviewed
• [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. (2016)
  • Author(s): Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
  • Journal Title: J Exp Med Volume: 213 Pages: 1441-58
  • DOI: 10.1084/jem.20151780.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells. (2016)
  • Author(s): Yang CC, Suzuki M, Yamakawa S, Uno S, Ishii A, Yamazaki S, Fukatsu R, Fujisawa R, Sakimura K, Tsurimoto T, Masai H
  • Journal Title: Nat. Commun. Volume: 7 Pages: 12135
  • DOI: 10.1038/ncomms12135
  • Peer Reviewed / Open Access
• [Journal Article] Ionic basis for membrane potential resonance in neurons of the inferiorolive. (2016)
  • Author(s): Matsumoto-Makidono Y, Nakayama H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, Kano M, Sakimura K, Hashimoto K.
  • Journal Title: Cell Rep. Volume: 16 Pages: 994-1004
  • DOI: 10.1016/j.celrep.2016.06.053
  • Peer Reviewed
• [Journal Article] Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells. (2016)
  • Author(s): Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonsert S, Nakauchi H, Hattori K, Heissig B.
  • Journal Title: Blood Volume: 128 Issue: 8 Pages: 1063-75
  • DOI: 10.1182/blood-2015-10-673103.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. (2016)
  • Author(s): Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA.
  • Journal Title: Cell Volume: 166 Pages: 1147-1162
  • DOI: 10.1016/j.cell.2016.07.025.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. (2016)
  • Author(s): Ishikawa, E., Kosako, H., Yasuda, T., Ohmuraya, M., Araki, K., Kurosaki, T., Saito, T. and Yamasaki, S.
  • Journal Title: Nat. Commun. Volume: 7 Pages: 12756
  • DOI: 10.1038/ncomms12756
  • Peer Reviewed / Open Access
• [Journal Article] ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism. (2016)
  • Author(s): Tian, Z., Miyata, K., Kadomatsu, T., Horiguchi, H., Takeda, N., Araki, K., Manabe, I., Fukuda, K., Otsu, K., Wada, J., Murohara, T., Mohri, S., Yamashita, J. K., Sano, M., Oike, Y., et al.
  • Journal Title: Nat. Commun. Volume: 7 Pages: 13016
  • DOI: 10.1038/ncomms13016.
  • Peer Reviewed / Open Access
• [Journal Article] SAD-B phosphorylation of CAST controls active zone vesicle recycling for synaptic depression. (2016)
  • Author(s): Mochida S, Hida Y, Tanifuji S, Hagiwara A, Hamada S, Abe M, Ma H, Yasumura M, Kitajima I, Sakimura K, Ohtsuka T
  • Journal Title: Cell Rep. Volume: 16 Pages: 2901-2913
  • DOI: 10.1016/j.celrep.2016.08.020
  • Peer Reviewed / Open Access
• [Journal Article] Spatiotemporal dynamics of lesion-induced axonal sprouting and its relationto functional architecture of the cerebellum. (2016)
  • Author(s): Dhar M, Brenner JM, Sakimura K, Kano M, Nishiyama H
  • Journal Title: Nat. Commun. Volume: 7 Pages: 12938
  • DOI: 10.1038/ncomms12938
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SCOP/PHLPP16 mediates circadian regulation of long-term recognition memory. (2016)
  • Author(s): Shimizu K, Kobayashi Y, Nakatsuji E, Yamazaki M, Shimba S, Sakimura K, Fukada Y
  • Journal Title: Nat. Commun. Volume: 7 Pages: 12926
  • DOI: 10.1038/ncomms12926
  • Peer Reviewed / Open Access
• [Journal Article] Forward genetic analysis of sleep in randomly mutagenized mice. (2016)
  • Author(s): Funato H, et al.
  • Journal Title: Nature Volume: 539 Pages: 378-383
  • DOI: 10.1038/nature20142.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells. (2016)
  • Author(s): Yao R, Oyanagi J, Natsume Y, Kusama D, Kato Y, Nagayama S, Noda T.
  • Journal Title: Oncogene Volume: 35 Issue: 47 Pages: 6109-6119
  • DOI: 10.1038/onc.2016.148.
  • Peer Reviewed
• [Journal Article] A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO. (2016)
  • Author(s): Lee GH, Fujita M, Takaoka K, Murakami Y, Fujihara Y, Kanzawa N, Murakami KI, Kajikawa E, Takada Y, Saito K, Ikawa M, Hamada H, Maeda Y, Kinoshita T.
  • Journal Title: J Cell Biol. Volume: 215 Pages: 705-718
  • DOI: 10.1083/jcb.201605121
  • Peer Reviewed / Open Access
• [Journal Article] Novel working hypothesis for pathogenesis of hematological malignancies : combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD). (2016)
  • Author(s): Kitamura T, Inoue D, et al
  • Journal Title: Journal of Biochemistry Volume: 159 Pages: 17-25
  • DOI: 10.1093/jb/mvv114
  • Peer Reviewed
• [Journal Article] A Diarylpentanoid Curcumin Analog Exhibits Improved Radioprotective Potential in the Intestinal Mucosa (2016)
  • Author(s): Fukuda, K, Uehara, Y, Nakata, E, Inoue, M, Shimazu, K, Yoshida, T, Kanda, H, Nanjo, H, Hosoi, Y, Yamakoshi, H, Iwabuchi, Y, Shibata, H
  • Journal Title: International Journal of Radiation Biology Volume: 92 Pages: 388-394
  • DOI: 10.3109/09553002.2016.1164910.
  • Peer Reviewed
• [Journal Article] CHD8 haploinsufficiency results in autistic-like phenotypes in mice. (2016)
  • Author(s): Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI.
  • Journal Title: Nature Volume: 537 Issue: 7622 Pages: 675-679
  • DOI: 10.1038/nature19357
  • Peer Reviewed
• [Journal Article] Mice that lack the C-terminal region of Reelin exhibit behaviora abnormalities related to neuropsychiatric disorders. (2016)
  • Author(s): Sakai K, Shoji H, Kohno T, Miyakawa T, Hattori M.
  • Journal Title: Sci Rep Volume: 6 Pages: 28636
  • DOI: 10.1038/srep28636
  • Peer Reviewed / Open Access
• [Journal Article] Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery. (2016)
  • Author(s): Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A.
  • Journal Title: J Biol Chem Volume: 291 Issue: 22 Pages: 11676-88
  • DOI: 10.1074/jbc.M116.714030
  • Peer Reviewed
• [Journal Article] Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain. (2016)
  • Author(s): Kim CK, Yang SJ, Pichamoorthy N, Young NP, Kauvar I, Jennings JH, Lerner TN, Berndt A, Lee SY, Ramakrishnan C, Davidson TJ, Inoue M, Bito H, Deisseroth K.
  • Journal Title: Nat Methods. Volume: 13 Issue: 4 Pages: 325-328
  • DOI: 10.1038/nmeth.3770
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity. (2016)
  • Author(s): Narita K, Katoh Y, Ojima K, Dan S, Yamori T, Ito A, Yoshida M, Katoh T.
  • Journal Title: European Journal of Organic Chemistry Volume: 34 Pages: 5667-5677
  • DOI: 10.1002/ejoc.201601023
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors. (2016)
  • Author(s): Narita K, Matsuhara K, Itoh J, Akiyama Y, Dan S, Yamori T, Ito A, Yoshida M, Katoh T.
  • Journal Title: Eur J Med Chem Volume: 121 Pages: 592-609
  • DOI: 10.1016/j.ejmech.2016.05.031
  • Peer Reviewed
• [Journal Article] Synthesis and in vitro cancer cell growth inhibition evaluation of 11-amino-modified 5-Me-indolo[2,3-b]quinolines and their COMPARE analyses. (2016)
  • Author(s): Okada M, Mei ZW, Hossain MI, Tominaga T, Takebayashi T, Murakami M, Yasuda M, Shigehiro T, Kasai T, Mizutani A, Murakami H, El Sayed Iel T, Dan S, Yamori T, Seno M, Inokuchi T.
  • Journal Title: Med Chem Res Volume: 25 Issue: 5 Pages: 879-892
  • DOI: 10.1007/s00044-016-1508-z
  • Peer Reviewed
• [Journal Article] Inhibition of the PI3K-Akt and mTORC1 signaling pathways promotes the elongation of vascular endothelial cells (2016)
  • Author(s): Tamura K, Ogawa M
  • Journal Title: J Cell Sci Volume: 129 Pages: 1165-1178
  • DOI: 10.1242/jcs.178434
  • Peer Reviewed / Open Access
• [Journal Article] α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15 (2016)
  • Author(s): Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS.
  • Journal Title: Sci Rep Volume: 6 Pages: 25895
  • DOI: 10.1038/srep25895
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic profiling reveals that collismycin A is an iron chelator. (2016)
  • Author(s): Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.
  • Journal Title: Sci Rep Volume: 6 Pages: 38385
  • DOI: 10.1038/srep38385
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. (2016)
  • Author(s): Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H.
  • Journal Title: Sci Rep Volume: 6 Pages: 26521
  • DOI: 10.1038/srep26521
  • Peer Reviewed / Open Access
• [Journal Article] Integrated profiling methods for identifying the targets of bioactive compounds : MorphoBase and ChemProteoBase. (2016)
  • Author(s): Muroi M, Futamura Y, Osada H.
  • Journal Title: Nat Prod Rep Volume: 33 Pages: 621-625
  • DOI: 10.1039/c5np00106d
• [Journal Article] Storkhead box 2 and melanoma inhibitory activity promote oral squamou cell carcinoma progression. (2016)
  • Author(s): Sasahira T, Nishiguchi Y, Fujiwara R, Kurihara M, Kirita T, Bosserhoff AK, Kuniyasu H.
  • Journal Title: Oncotarget Volume: 7 Pages: 26754-26764
  • DOI: 10.18632/oncotarget.8495.
  • Peer Reviewed
• [Presentation] エストロゲン依存性乳癌細胞のタモキシフェン耐性獲得におけるNF-κB経路の役割 (2017)
  • Author(s): 山口憲孝, 中山祐治, 山口直人
  • Organizer: 第137回日本薬学会年会
  • Place of Presentation: 東北大学川内キャンパス(宮城県、仙台市)
  • Year and Date: 2017-03-25 – 2017-03-27
• [Presentation] Genome-wide association study of pain sensitivity in cold pressor test. (2017)
  • Author(s): Takahashi K, Fukuda K, Nishizawa D, Kasai S, Kokita Y, Ichinohe T, Ikeda K
  • Organizer: 2017 LADR(International Association for Dental Research) General Session & Exhibition
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Aplysiatoxin単純化アナログ・10-Me-aplog-1のフェノール性側鎖が各種生物活性に与える影響 (2017)
  • Author(s): 花木祐輔、菊森将之、徳田春邦、岡村睦美、旦 慎吾、柳田 亮、入江一浩
  • Organizer: 2017年度日本農芸化学会大会
  • Place of Presentation: 京都女子大学(京都府京都市)
  • Year and Date: 2017-03-17 – 2017-03-20
• [Presentation] The rewarding effect of methylphenidate on attention deficit/hyperactivity disorder model mice. (2017)
  • Author(s): Ikekubo Y, Ide S, Takamatsu Y, Takeda TC, Nagasawa S, Hua J, Ikeda K
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎ブリックホール・長崎新聞文化ホール(長崎県長崎市)
  • Year and Date: 2017-03-16
• [Presentation] CRISPR/Cas9 Mediated Genome Editing and its Application for the Study of Reproduction (2017)
  • Author(s): 伊川 正人
  • Organizer: The 20th US-Japan Cellular and Gene Therapy Conference
  • Place of Presentation: FDA White Oak Campus (Silver Spring, Maryland, USA)
  • Year and Date: 2017-03-09
  • Int'l Joint Research / Invited
• [Presentation] Distinct roles of opioid and dopamine systems in lateral hypothalamic intracranial self-stimulation. (2016)
  • Author(s): Ikeda K, Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I
  • Organizer: The 55th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 55th Annual Meeting)
  • Place of Presentation: Hollywood, Florida, USA
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] Identification and Selective Stabilization of G-quadruplexes by Small Molecules (2016)
  • Author(s): 長澤和夫
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-11-30 – 2016-12-02
  • Invited
• [Presentation] Quantitative analysis of T cell repertoire and homeostasis (2016)
  • Author(s): Taishin Akiyama and Tetsuya J. Kobayashi
  • Organizer: 第54回生物物理学会
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-11-26
  • Invited
• [Presentation] Three dimensional analysis of walking legs and their controlling muscles in the centipede Scolopendra subspinipes mutilans using micro-CT technique (2016)
  • Author(s): H. Aonuma, S. Kuroda, K. Yasui, T. Kano and A. Ishiguro
  • Organizer: 22nd International congree of Zoology and 87th meeting of Zoological Society of Japan
  • Place of Presentation: OIST, 沖縄コンベンションセンター, 沖縄県, 恩納村宜野湾市
  • Year and Date: 2016-11-14 – 2016-11-19
  • Int'l Joint Research
• [Presentation] Role of R-type calcium channel (Cav2.3) in medial habenula to interpeduncular nucleus pathway (2016)
  • Author(s): Bhandari P, Parajuli LK, Takao K, Miyakawa T, Kobayashi Y, Tanaka KF, Shigemoto R.
  • Organizer: 46th Annual meeting of Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-11-13
• [Presentation] Tutorial contents on neuroinfomrmatics platforms. (2016)
  • Author(s): Yamaguchi Y, Hattori S, Takao K, Okumura Y, Suenaga S, Ishii I, Honda A, Ogawa M, Usui S, Miyakawa T
  • Organizer: 46th Annual meeting of Socisty for Neuroscience
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-11-12
• [Presentation] Functional analysis of the RNA-binding protein PTBP1 and its paralogue PTBP2 in development (2016)
  • Author(s): 吉田進昭
  • Organizer: Mechanisms of Molecular and Cellular Immunity 1964-2016
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2016-11-04
  • Invited
• [Presentation] Partial correlation-based functional connectivity analysis of the optical intrinsic signals of the mouse neocortex during resting state (2016)
  • Author(s): Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
  • Organizer: 8th Internat Workshop Biosignal Interpret (BSI2016)
  • Place of Presentation: 大阪国際交流センター(大阪府大阪市)
  • Year and Date: 2016-11-01 – 2016-11-03
  • Int'l Joint Research
• [Presentation] Role of iron in carcinogenesis. (2016)
  • Author(s): Toyokuni S.
  • Organizer: International Symposium on Redox Biology and Mitochondrial Medicine & 2016 Cross-Strait Free Radical Symposium
  • Place of Presentation: New Taipei City, Taiwan
  • Year and Date: 2016-10-21 – 2016-10-22
  • Int'l Joint Research / Invited
• [Presentation] Analysis of Asxl1-MT conditional knock-in mice (2016)
  • Author(s): 永瀬玲奈
  • Organizer: 第78会日本血液学会学術総会
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-13 – 2016-10-15
• [Presentation] CRISPR/Cas9 mediated genome editing in mice (2016)
  • Author(s): 伊川 正人
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-06 – 2016-10-08
  • Invited
• [Presentation] Targeting distant metastasis of colorectal cancer with a combination of anti-claudin-4 antibody (2016)
  • Author(s): Fujiwara R, Luo Y, Sasaki T, Nishiguchi Y, Ohmori H, Hashimoto Y, Kondo M, Kuniayasu H
  • Organizer: 76th Annual Meeting of Japanese Association for Cancer
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-06 – 2016-10-08
• [Presentation] Genetic mechanisms underlying individual differences in sensitivity to pain and opioids. (2016)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-09-27
  • Int'l Joint Research / Invited
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] Insertion Characteristics Evaluation of Si Opto-Neural Probe with Embedded Optical fiber (2016)
  • Author(s): Takumi Morikawa, Takuya Harashima, Takafumi Fukushima, Hisashi Kino, and Tetsu Tanaka
  • Organizer: 2016 International Conference on Solid State Devices and Materials
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-09-26 – 2016-09-29
  • Int'l Joint Research
• [Presentation] Development of Si Neural Probe with Piezoresistive Force Sensor for Insertion Force Monitoring (2016)
  • Author(s): Takuya Harashima, Takumi Morikawa, Hisashi Kino, Takafumi Fukushima, Tetsu Tanaka
  • Organizer: 2016 International Conference on Solid State Devices and Materials
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-09-26 – 2016-09-29
  • Int'l Joint Research
• [Presentation] ES細胞を用いたゲノム編集とキメラ解析 (2016)
  • Author(s): 伊川 正人
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-09-25 – 2016-09-27
  • Invited
• [Presentation] Plenary lecture 1 : Insights into chemical reaction mechanism in plasma medicine from the viewpoint of oxidative stress. (2016)
  • Author(s): Toyokuni S.
  • Organizer: th International Conference on Plasma Medicine.
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research / Invited
• [Presentation] Analysis of MDS mice model induced by ASXL1 and RUNX1 mutants (2016)
  • Author(s): Nagase R, Inoue D, Saika M, Hou HA, Chou WC, Kawabata KC, Harada H, Kanai A, Goyama S, Honda H, Tien HF, Kitamura T
  • Organizer: 45th Annual Scientific Meeting of ISEH
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2016-08-25 – 2016-08-28
• [Presentation] Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. (2016)
  • Author(s): Nishizawa D, Yoshida K, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-14
  • Int'l Joint Research
• [Presentation] Increased number of glial and neuronal cells in the periaqueductal gray matter (PAG) of mu-opioid receptor knockout mice. (2016)
  • Author(s): Sasaki K, Sora I, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Kawashima R
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-11
  • Int'l Joint Research
• [Presentation] Sex differences in voluntary drinking by mu-opioid receptor knockout mice following early stress. (2016)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-11
  • Int'l Joint Research
• [Presentation] The abolished rewarding effect of methylphenidate in dopamine transporter knockout mice, a model for attention deficit/hyperactivity disorder. (2016)
  • Author(s): Ide S, Takamatsu Y, Ikekubo Y, Takeda TC, Nagasawa S, Hua J, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Transcriptome analysis in Tsc2 heterozygous knockout mice. (2016)
  • Author(s): Kasai S, Sato A, Kashii H, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Kores
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery. (2016)
  • Author(s): Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Association between the rs7583431single-nucleotide polymorphism close to the activating transcription factor 2(ATF2) gene and the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test. (2016)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Therapsutic effects of cholinergic drug on mechanical allodynia in the mouse partial sciatic nerve ligation model. (2016)
  • Author(s): Yamanishi Y, Takamatsu Y, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Effects of chronic tryptophan depletion on autism spectrum disorder like behaviors in serotonin transporter knockout and heterozygous mice. (2016)
  • Author(s): Tanaka M, Sato A, Hagino Y, Sora I, Murphy D, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-04
  • Int'l Joint Research
• [Presentation] Novel embryonic precursor cells of medullary thymic epithelial cells expressing Aire (2016)
  • Author(s): Nobuko Akiyama, Riko Yoshinaga, Jun-ichiro Inoue, and Taishin Akiyama
  • Organizer: ThymUS International Confernce
  • Place of Presentation: Maui, Hawaii, USA
  • Year and Date: 2016-06-06
  • Int'l Joint Research
• [Presentation] Mouse Behavioral Phenotype Database. (2016)
  • Author(s): Hattori S, Shoji H, Takao K, Miyakawa T
  • Organizer: INCF Japan International Workshop : Advances in Neuroinformatics
  • Place of Presentation: 理化学研究所(埼玉県和光市)
  • Year and Date: 2016-05-28 – 2016-05-29
• [Presentation] Cancer as a ferrotoxic disease : what we have learned from animal studies toward its prevention. (2016)
  • Author(s): Toyokuni S.
  • Organizer: The 9th International Conference on the Biology, Chemistry, and the Therapeutic Applications of Nitric Oxide.
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-05-20 – 2016-05-22
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9 mediated genome editing and its application for the study of reproduction (2016)
  • Author(s): 伊川 正人
  • Organizer: 2016 AMMRA meeting
  • Place of Presentation: ホテルおかだ(神奈川県足柄下郡箱根町)
  • Year and Date: 2016-05-20 – 2016-05-21
  • Int'l Joint Research / Invited
• [Presentation] Iron overload and genome alteration. (2016)
  • Author(s): Toyokuni S.
  • Organizer: Oxygen Club of California 2016 : Oxidants and antioxidants in biology ; Redox medicine and nutrition.
  • Place of Presentation: University of California Davis, Davis, CA, USA
  • Year and Date: 2016-05-04 – 2016-05-06
  • Int'l Joint Research / Invited
• [Book] Japanese Scientists in Science 2015 (2016)
  • Author(s): 宮田 治彦、伊川 正人
  • Pages: 64
  • Total Pages: 80
  • Publisher: American Association for the Advancement of Science (AAAS)
• [Book] HORMONE FRONTIER IN GYNECOLOGY Vol.23 No.2 (2016)
  • Author(s): 伊川 正人
  • Pages: 13-20
  • Total Pages: 84
  • Publisher: メディカルレビュー社
• [Book] 実験医学別冊 マウス表現型解析スタンダード (2016)
  • Author(s): 美野輪 治、八尾 良司
  • Pages: 46-55
  • Total Pages: 347
  • Publisher: 羊土社
• [Book] 実験医学別冊 マウス表現型解析スタンダード (2016)
  • Author(s): 野田 大地、大字 亜沙美、伊川 正人
  • Pages: 74-82
  • Total Pages: 351
  • Publisher: 羊土社
• [Book] Addiction Medicine (Second Edition) (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Pages: 52-53
  • Total Pages: 672
  • Publisher: OXFORD UNIVERSITY PRESS
• [Book] The Neuropathology of Drug Addictions and Substance Misuse. (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Pages: 909-919
  • Total Pages: 1132
  • Publisher: Academic Press
• [Book] The Neuropathology of Drug Addictions and Substance Misuse. (2016)
  • Author(s): Yamamoto H, Sawada W, Kamegaya E, Hagino Y, Ikeda K, Sora I, Mishina M, Yamamoto T
  • Pages: 604-612
  • Total Pages: 1182
  • Publisher: Academic Press
• [Book] Current Research in Cancer 10-Role of CD10 in the metastasis of colorectal cancer to the liver. (2016)
  • Author(s): Kuniyasu H, Fujii K, Ohmori H, Fujiwara-Tani R, Luo Y, Sasaki T
  • Pages: 31-40
  • Total Pages: 188
  • Publisher: Research Media, Karela, India
• [Book] Current Research in Cancer 10-Significance of anti-CLDN4 extracellular domain antibody in cancer treatment. (2016)
  • Author(s): Fujiwara-Tani R, Ohmori H, Fujii K, Sasaki T, Luo Y, Kuniyasu H
  • Pages: 41-51
  • Total Pages: 188
  • Publisher: Research Media, Karela, India
• [Remarks] 公益財団法人東京都医学総合研究所ホームページ
  • URL: http://www.igakuken.or.jp/
• [Remarks] 依存性薬物プロジェクトホームページ
  • URL: http://www.igakuken.or.jp/abuse/
• [Remarks] 先端モデル動物支援ブラットフォームホームページ
  • URL: http://model.umin.jp/
• [Remarks] I Love GFPホームページ
  • URL: https://sites.google.com/site/ilovegfp/Home
• [Patent(Industrial Property Rights)] 第四世代EGFRチロシンキナーゼ阻害剤 (2017)
  • Inventor(s): 岩尾正倫、福田勉、石橋郁人、上原至雅、西谷直之、奥裕介、旦慎吾、矢守隆夫
  • Industrial Property Rights Holder: 国立大学法人長崎大学、学校法人岩手医科大学、公益財団法人がん研究会
  • Industrial Property Rights Type: 特願
  • Industrial Property Number: 特願2017-64866
  • Filing Date: 2017-03-29