コホート・生体試料支援プラットフォーム

2020 Fiscal Year Annual Research Report

• Project/Area Number: 16H06277
• Research Institution: The University of Tokyo
• Principal Investigator: 村上 善則 東京大学, 医科学研究所, 教授
• Project Period (FY): 2016 – 2021
• Keywords: 生体試料支援 / 健常人コホート / ブレインバンク / 最先端解析技術支援 / 臨床検体

Outline of Annual Research Achievements

①総括支援活動 : 若手支援研究成果発表会をオンラインで開催した(2021/2/9)。コホート・生体試料支援プラットフォーム(以下、CoBiA)の各支援機能の説明と教育講演に続き、31名の若手研究者がCoBiAの支援を受けて行った研究成果の発表と情報交換を行った。また、東北メディカル・メガバンク等国内4ゲノムコホート等と、日本多施設共同コーホート(J-MICC)研究の間で、共同研究の実施を合意するなど、わが国のゲノムコホート間の連携が進んだ。また日本疫学会のホームページでの告知、関連分野の科研費取得者へのダイレクトメールなど、研究支援の周知を図った。
②コホートによるバイオリソース支援活動 : 今年度は291件の研究支援を実施した。またコホート(J-MICC)研究の追跡調査データ(死亡及びがん罹患。遺伝情報利用も含む)を用いた研究の解析テーマ募集を開始した。J-MICC研究において、新たにがん罹患追跡データを基盤として整備し、研究支援に供した。
③ブレインリソースの整備と活用支援 : 大阪大学に本邦初のブレインバンク部門を創設し、大阪刀根山医療センター、宇多野病院、大阪府立母子医療センター、連合小児自閉症ゲノム・不死化細胞トリオ、法医学自殺レジストリを統合し、筋萎縮性側索硬化症エピゲノム研究等に貢献した。
④生体試料による支援活動 : 298課題に生体機能分子の高感度解析・技術支援と共同研究ネットワーク構築支援を実施した。142課題にがん関連試料・情報(組織、血液)を提供した。7,774試料(血清、リンパ球、凍結組織、パラフィン包埋組織、DNA等)を収集し、3,581試料を提供した。ヒト試料解析研究の申請支援と病理形態学的解析支援を実施した。解析支援・連携構築支援・試料収集及び提供支援体制を強化した。学会・研究会及び公開講座を通じたヒト生体試料の活用研究の普及・啓発講演を実施した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : 若手支援研究成果発表会における研究者の交流を通じて、CoBiA各班間の連携強化と被支援者との学際的連携を図り、新たな共同研究や支援機能の構築に向けた情報共有と学術交流を実施できた。
全国で、総研究参加者約36万名のゲノムコホート連携が進み、本プラットフォームを構成するコホート研究が一定の役割を果たしつつある。また広報活動により、これまでとは異なる研究グループからの支援に関する問い合わせが増え、支援申請に結びついた。
②コホートによるバイオリソース支援活動 : 200件以上の研究支援を実施し、支援を受けた研究成果が、一流国際雑誌も含め多くの掲載論文として公表された。またコホート研究の死亡およびがん罹患追跡データを整備し、研究支援内容の充実を図ることができた。さらに、がん早期診断マーカーの検証支援を再開した。
③ブレインリソースの整備と活用支援 : 大阪大学、京都大学、奈良県立医科大学、和歌山県立医科大学と連携し、日本ブレインバンクネットワーク関西拠点を創設した。阪大法医学教室、大阪監察事務局との連携、連合小児発達学研究科を核とし、自閉症バイオリソース、自殺者死後脳レジストリ構築を開始した。コロナ禍での剖検障壁に、患者、医師、研究者の連携の下、生前献脳同意を推進し、グループ全体で昨年と同レベルのリソース構築、提供を達成できた。
④生体試料による支援活動 : 日進月歩で多様化する生命科学研究の動向を踏まえ、新規の高精度分子解析技術による解析支援体制の強化、生体試料バンクのISO20387「バイオバンキングの一般要求事項」に準じた体制整備、健常者血清の提供体制の強化と支援内容・成果の広報・啓発を進めた。この結果、支援課題数は生体機能分子解析・技術・連携支援及び生体試料収集・提供支援ともに令和2年度の研究支援実施計画を上回り、国際的にインパクトのある学術論文発表に貢献した。

Strategy for Future Research Activity

①総括支援活動 : CoBiAと支援利用者との情報共有を促進し、広範で多彩なニーズに迅速かつ高品質の支援を提供するため、令和3年度も若手支援研究成果発表会を開催する。
ゲノムコホート連携については、共同研究契約の締結などを進め、共同研究を開始する。また学会での広報、関連分野の科研費取得者への案内などを通じて本支援活動の周知を継続する。
②コホートによるバイオリソース支援活動 : 支援件数の増加を図るため、関連分野の研究室および科研費代表研究者へのダイレクトメール、関係学会のメーリングリストなどで支援活動の広報を行う。支援の主要な基盤であるJ-MICC研究(参加者数10.3万人)について、第二次調査データ、および虚血性心疾患・脳卒中罹患データを整備する。また、がん罹患症例と対照のGWAS用タイピングを継続するとともに、データを順次、支援に使用する。
③ブレインリソースの整備と活用支援 : 本邦ブレインバンクの国際的優越性は、全身剖検を基盤としており、脳だけでなく脊髄、末梢組織リソースを持つ点、患者・医師協力の元臨床症状・放射線画像・バイオリソースとの統合化が可能である点、神経病理学会ブレインバンク委員会の指導の元国際的に一流の神経病理診断に基づく運用・管理が可能である点からなる。基礎神経科学者に対するヒト死後脳研究への勧誘を継続し、研究者数増加への努力を今後も継続する。
④生体試料による支援活動 : 多彩な生命科学領域のニーズと技術革新に迅速に対応して支援成果を研究者に還元するため、先進的な分子解析支援技術の導入・強化を進め、新倫理指針に対応し、国際水準の質を確保した多彩なヒト試料の収集・提供を進める。先進的研究拠点等との連携を強化し、次相を見据えた学際的共同研究の構築支援を行い、学会や教育の場で研究者や若手向けの普及・啓発活動を展開する。また、コロナ禍で支障をきたした研究への支援を強化する。

Research Products

• [Journal Article] A Genome-wide Association Study on Confection Consumption in a Japanese Population-The Japan Multi-Institutional Collaborative Cohort study. (2021)
  • Author(s): Suzuki T, Nakamura Y, Doi Y, Narita A, Shimizu A, Imaeda N, Goto C, Kuriki K, et al.
  • Journal Title: Br J Nutr.
  • DOI: 10.1017/S0007114521000684
  • Peer Reviewed
• [Journal Article] Alteration of mucins in the submandibular gland during aging in mice. (2021)
  • Author(s): Kameyama, A., Thet Tin, WW., Nishijima, R., Yamakoshi, K.
  • Journal Title: Archives of Oral Biology Volume: 121 Pages: 104967
  • DOI: 10.1016/j.archoralbio.2020.104967
  • Peer Reviewed
• [Journal Article] Assessing the Relationship between Helicobacter pylori and Chronic Kidney Disease. (2021)
  • Author(s): Hata K, Koyama T, Ozaki E, Kuriyama N, Mizuno S, Matsui D, Watanabe I, Uehara R, Watanabe Y.
  • Journal Title: Healthcare Volume: 9 Pages: 162
  • DOI: 10.3390/healthcare9020162
  • Peer Reviewed / Open Access
• [Journal Article] Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study. (2021)
  • Author(s): Fujii R, Hishida A, Nishiyama T, Nakatochi M, Matsuo K, Ito H, Nishida Y, ...Kuriki K, et al.
  • Journal Title: J Epidemiol.
  • DOI: 10.2188/jea.JE20200540
  • Peer Reviewed / Open Access
• [Journal Article] Association between circulating vascular-related microRNAs and an increase in blood pressure : a 5-year longitudinal population-based study (2021)
  • Author(s): Suzuki K, Yamada H, Fujii R, Munetsuna E, Ando Y, Ohashi K, Ishikawa H, Yamazaki M, Maeda K, Hashimoto S, Hamajima N.
  • Journal Title: J Hypertens. Volume: 39 Issue: 1 Pages: 84-89
  • DOI: 10.1097/HJH.0000000000002606
  • Peer Reviewed
• [Journal Article] Association between nutrient patterns and fatty liver index : Baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushim, Japan (2021)
  • Author(s): Nguyen Van Tien, Kokichi Arisawa, Hirokazu Uemura, Nahomi Imaeda, Chiho Goto, Sakurako Katsuura-Kamano
  • Journal Title: Journal of Epidemiology
  • DOI: 10.2188/jea.je20200447
  • Peer Reviewed / Open Access
• [Journal Article] Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice. (2021)
  • Author(s): Kameyama, A., Nishijima, R., Yamakoshi, K.
  • Journal Title: PLoS One Volume: 16 Issue: 1 Pages: e0245607
  • DOI: 10.1371/journal.pone.0245607
  • Peer Reviewed / Open Access
• [Journal Article] Body mass index and colorectal cancer risk : A Mendelian randomization study. (2021)
  • Author(s): Suzuki S, Goto A, Nakatochi M, Narita A, Yamaji T, Sawada N, Katagiri R, …, Kuriki K, et al.
  • Journal Title: Cancer Sci.
  • DOI: 10.1111/cas.14824
  • Peer Reviewed / Open Access
• [Journal Article] Dietary fish and ω-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels. (2021)
  • Author(s): Fujii R, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Ando Y, Maeda K, Tsuboi Y, Ohashi K, Ishikawa H, Hagiwara C, Wakai K, Hashimoto S, Hamajima N, Suzuki K.
  • Journal Title: Nutrition Volume: 81 Pages: 110951
  • DOI: 10.1016/j.nut.2020.110951
  • Peer Reviewed
• [Journal Article] Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor (2021)
  • Author(s): Maeda J, Suhara T, Higuchi M, Sahara N, 他17名
  • Journal Title: Brain Communications Volume: 3 Issue: 1 Pages: fcab011
  • DOI: 10.1093/braincomms/fcab011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimation of the window period of human T-cell leukemia virus type 1 and 2 tests by a lookback study of seroconverters among Japanese voluntary blood donors (2021)
  • Author(s): Yasuko Sagara, Hitomi Nakamura, Midori Yamamoto, Toshinobu Ezaki, Tomohide Koga, Masuhiro Shimamura, Masahiro Satake, Kazuo Irita
  • Journal Title: Transfusion
  • DOI: 10.1111/trf.16213
  • Peer Reviewed / Open Access
• [Journal Article] Extracellular release of ILEI/FAM3C and amyloid-beta is associated with the activation of distinct synapse subpopulations. (2021)
  • Author(s): Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M.
  • Journal Title: Journal of Alzheimer's Disease
  • DOI: 10.3233/JAD-201174
  • Peer Reviewed
• [Journal Article] Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese : the Japan Multi-Institutional Collaborative Cohort Study. (2021)
  • Author(s): Hishida A, Nakatochi M, Tamura T, Nagayoshi M, Okada R, Kubo Y, Tsukamoto M, ... Kuriki K, et al.
  • Journal Title: Nagoya J Med Sci. Volume: 83 Issue: 1 Pages: 183-194
  • DOI: 10.18999/nagjms.83.1.183
  • Peer Reviewed / Open Access
• [Journal Article] Green tea and coffee consumption and all-cause mortality among persons with and without stroke or myocardial infarction (2021)
  • Author(s): Teramoto M, Muraki I, Yamagishi K, Tamakoshi A, Iso H
  • Journal Title: Stroke Volume: 52 Pages: 957-965
  • DOI: 10.1161/STROKEAHA.120.032273
  • Peer Reviewed / Open Access
• [Journal Article] High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies (2021)
  • Author(s): Tagai K, Suhara T, Sahara N, Higuchi M, Shimada H, 他33名
  • Journal Title: Neuron Volume: 109 Pages: 42-58
  • DOI: 10.1016/j.neuron.2020.09.042
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Histidine-rich glycoprotein stimulates human neutrophil phagocytosis and prolongs survival through CLEC1A. (2021)
  • Author(s): Takahashi Y, Wake H, Sakaguchi M, Yoshii Y, Teshigawara K, Wang D, Nishibori M.
  • Journal Title: J Immunol Volume: 206 Pages: 737-750
  • DOI: 10.4049/jimmunol.2000817
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Incorporating kidney disease measures into cardiovascular risk prediction : Development and validation in 9 million adults from 72 datasets (2021)
  • Author(s): Matsushita K, Jassal SK, Sang Y, Ballew SH, Grams ME, Yatsuya H, Zhang L, Schaeffner E, Coresh J, et al.
  • Journal Title: EClinicalMedicine
  • DOI: 10.1016/j.eclinm.2020.100552
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inverse correlation between serum high-molecular-weight adiponectin and proinsulin level in a Japanese population : The Dynamics of Lifestyle and Neighborhood Community on Health Study (2021)
  • Author(s): Nakamura A, Miyoshi H, Ukawa S, Nakamura K, Nakagawa T, Terauchi Y, Tamakoshi A, Atsumi T.
  • Journal Title: J Diabetes Investig Volume: 12 Issue: 1 Pages: 63-66
  • DOI: 10.1111/jdi.13323
  • Peer Reviewed / Open Access
• [Journal Article] Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort : the JACC study (2021)
  • Author(s): Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, Tamakoshi A, Iso H
  • Journal Title: Sci Rep Volume: 11 Pages: 1531
  • DOI: 10.1038/s41598-020-79860-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Manganese intake from foods and beverages is associated with a reduced risk of type 2 diabetes (2021)
  • Author(s): Eshak ES, Muraki I, Imano H, Yamagishi K, Tamakoshi A, Iso H
  • Journal Title: Maturitas Volume: 143 Pages: 127-131
  • DOI: 10.1016/j.maturitas.2020.10.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease (2021)
  • Author(s): Sobue A, Kimine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido T. C., Sahara N, Higuchi M, Ogi T, Yamanaka K.
  • Journal Title: Acta Neuropathologica Communications Volume: 9 Pages: 1
  • DOI: 10.1186/s40478-020-01099-x
  • Peer Reviewed / Open Access
• [Journal Article] Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study. (2021)
  • Author(s): Koyama T, et al.
  • Journal Title: Sci Rep. Volume: 11 Pages: 305
  • DOI: 10.1038/s41598-020-79525-2
  • Peer Reviewed / Open Access
• [Journal Article] Perceived stress, depressive symptoms, and cortisol-to-cortisone ratio in spot urine in 6878 older adults (2021)
  • Author(s): Shimanoe, C., Matsumoto A., Hara, M., Akao C., Nishida, Y., Horita, M., Nanri H., Higaki, Y., Tanaka, K
  • Journal Title: Psychoneuroendocrinology Volume: 125 Pages: 105125
  • DOI: 10.1016/j.psyneuen.2020.105125
  • Peer Reviewed
• [Journal Article] Relationship of Hemoglobin Level and Plasma Coproporphyrin-I Concentrations as an Endogenous Probe for Phenotyping OATP1B (2021)
  • Author(s): Suzuki Y, Sasamoto Y, Koyama T, Yoshijima C, Oda A, Nakatochi M, Kubo M, Momozawa Y, Uehara R, Ohno K
  • Journal Title: Clin Transl Sci
  • DOI: 10.1111/cts.12996
  • Peer Reviewed / Open Access
• [Journal Article] Reproducibility and validity of food group intake in a short food frequency questionnaire for the middle-aged Japanese population. (2021)
  • Author(s): Imaeda N, Goto C, Sasakabe T, Mikami H, Oze I, Hosono A, Naito M, ... Kuriki K, et al.
  • Journal Title: Environ Health Prev Med. Volume: 26 Issue: 1
  • DOI: 10.1186/s12199-021-00951-3
  • Peer Reviewed / Open Access
• [Journal Article] Substantially Increased Plasma Coproporphyr in-I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population (2021)
  • Author(s): Suzuki Y, Sasamoto Y, Koyama T, Yoshijima C, Nakatochi M, Kubo M, Momozawa Y, Uehara R, Ohno K.
  • Journal Title: Clin Transl Sci Volume: 14 Issue: 1 Pages: 382-388
  • DOI: 10.1111/cts.12889
  • Peer Reviewed / Open Access
• [Journal Article] The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis. (2021)
  • Author(s): Araki K, Kinoshita R, Tomonobu N, Yamamoto KI, Murata H, Suzawa K, Shien K, Yamamoto H, Okazaki M, Nishibori M, Miyahara N, Toyooka S, Sakaguchi M.
  • Journal Title: J Mol Med (Berl) Volume: 99 Pages: 131-145
  • DOI: 10.1007/s00109-020-02001-x
  • Peer Reviewed
• [Journal Article] Disclosure of secondary findings in exome sequencing of 2480 Japanese cancer patients. (2020)
  • Author(s): Horiuchi Y, Matsubayashi H, Kiyozumi Y, Nishimura S, Higashigawa S, Kado N, Nagashima T, Mizuguchi M, Ohnami S, Arai M, Urakami K, Kusuhara M, Yamaguchi K.
  • Journal Title: Hum Genet
  • DOI: 10.1007/s00439-020-02207-6
  • Peer Reviewed
• [Journal Article] Genome wide association study of HTLV-1-associated myelopathy/tropical spastic paraparesis in the Japanese population. (2020)
  • Author(s): Penova M, Kawaguchi S, Yasunaga JI, Kawaguchi T, Watanabe T, Uchimaru K, Iwanaga M, Utsunomiya A, Tabara Y, Paul R, Yamano Y, Matsuoka M, Matsuda F.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 118 Pages: e2004199118
  • DOI: 10.1073/pnas.2004199118.PMID:33649182
  • Peer Reviewed
• [Journal Article] Kobayashi S, Iwanaga M, Utsunomiya A, Watanabe T, Uchimaru K, Overexpression of aberrant Wnt5a and its effect on acquisition of malignant phenotypes in adult T-cell leukemia/lymphoma (ATL)cells. (2020)
  • Author(s): Nakano K, Chihara Y, Kobayashi S, Iwanaga M, Utsunomiya A, Watanabe T, Uchimaru K.
  • Journal Title: Sci Rep. Volume: 11 Pages: 4114
  • DOI: 10.1038/s41598-021-83613-2
  • Peer Reviewed / Open Access
• [Journal Article] A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern. (2020)
  • Author(s): Suzuki H, Nakamura Y, Matsuo K, Imaeda N, Goto C, Narita A, Shimizu A, …, Kuriki K …
  • Journal Title: Eur J Clin Nutr.
  • DOI: 10.1038/s41430-020-00823-z
  • Peer Reviewed
• [Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo (2020)
  • Author(s): Saito M, Hasegawa H, et al, Uchimaru K, Morishita K, Watanabe T, Miyazaki Y, Yanagihara K
  • Journal Title: Int J Hematol Volume: 112 Issue: 3 Pages: 300-306
  • DOI: 10.1007/s12185-020-02935-5
  • Peer Reviewed / Open Access
• [Journal Article] A high-throughput detection method for the clonality of Human T-cell Leukemia Virus type-1-infected cells in vivo. (2020)
  • Author(s): Masumichi Saito, Hiroo Hasegawa, Shunsuke Yamauchi, et al.
  • Journal Title: International Journal of Hematology Volume: 112 Issue: 3 Pages: 300-306
  • DOI: 10.1007/s12185-020-02935-5
  • Peer Reviewed
• [Journal Article] A nobel multivariate index for cancer risk detection based on the serum trace elements : Metallo-Balance Method. (2020)
  • Author(s): Okamoto N, Mikami H, Nakamura Y, Kusakabe M, Fujimoto S, Ueda M, Inagaki S, Miyagi Y, Nagase H, et al
  • Journal Title: Journal of Cancer Epidemiology and Prevention Volume: 5 Pages: 1-9
  • DOI: 10.36648/cancer.5.1.4
  • Peer Reviewed / Open Access
• [Journal Article] ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men : a genome-wide G × E interaction analysis (2020)
  • Author(s): Yoichi Sutoh, Tsuyoshi Hachiya, Yuji Suzuki, Shohei Komaki, Hideki Ohmomo, Keisuke Kakisaka, Ting Wang, Yasuhiro Takikawa & Atsushi Shimizu
  • Journal Title: Scientific Reports Volume: 10 Pages: 16227
  • DOI: 10.1038/s41598-020-73263-1
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of a plasmid encoding botulinum neurotoxin type G gene in Clostridium argentinense. (2020)
  • Author(s): Sakaguchi Y, Uchiyama J, Také A, Gotoh K, Sakaguchi M, Suzuki T, Yamamoto Y, Hosomi K, Kohda T, Mukamoto M, Kozaki S, Hayashi S, Oguma K.
  • Journal Title: Anaerobe Volume: 66 Pages: 102281
  • DOI: 10.1016/j.anaerobe.2020.102281
  • Peer Reviewed
• [Journal Article] Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic BRAF Mutation. (2020)
  • Author(s): Miyauchi S, Shien K, Takeda T, Araki K, Nakata K, Miura A, Tomida S, Yamane M, Sakaguchi M, Toyooka S.
  • Journal Title: Anticancer Res Volume: 40 Pages: 2667-2673
  • DOI: 10.21873/anticanres.14237
  • Peer Reviewed
• [Journal Article] Are Japanese women less physically active than men? Findings from the DOSANCO Health Study. (2020)
  • Author(s): Amagasa S, Inoue S, Ukawa S, Sasaki S, Nakamura K, Yoshimura A, Tanaka A, Kimura T, Nakagawa T, Imae A, Ding D, Kikuchi H, Tamakoshi A.
  • Journal Title: J Epidemiol.
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  • DOI: 10.2188/jea.JE20200147
  • Peer Reviewed / Open Access
• [Journal Article] Surgical margin status and recurrence pattern in invasive vulvar Paget's disease : A Japanese Gynecologic Oncology Group study. (2020)
  • Author(s): Matsuo K, Nishio S, Matsuzaki S, Iwase H, Kagami S, Soeda S, Usui H, Nishikawa R, Mikami M, Enomoto T.
  • Journal Title: Gynecol Oncol
  • DOI: 10.1016/j.ygyno.2020.12.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synergistic Regulation of Hepatic Fsp27b Expression by HNF4α and CREBH. (2020)
  • Author(s): Kasano-Camones CI, Takizawa M, Iwasaki W, Sasaki S, Hamada M, Morimoto A, Sakaguchi M, Gonzalez FJ, Inoue Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 530 Pages: 432-439
  • DOI: 10.1016/j.bbrc.2020.05.070
  • Peer Reviewed / Open Access
• [Journal Article] Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells. (2020)
  • Author(s): Rie Kajino-Sakamoto, Teruaki Fujishita, Makoto Mark Taketo, Masahiro Aoki.
  • Journal Title: Oncogene Volume: 40 Pages: 408-420
  • DOI: 10.1038/s41388-020-01541-3
  • Peer Reviewed
• [Journal Article] The Association of Daily Physical Activity Behaviors with Visceral Fat. (2020)
  • Author(s): Ando S, Koyama T, Kuriyama N, Ozaki E, Uehara R.
  • Journal Title: Obes Res Clin Pract. Volume: 14 Pages: 531-535
  • DOI: 10.1016/j.orcp.2020.10.004
  • Peer Reviewed
• [Journal Article] The interaction between mitochondrial haplogroups (M7a/D) and physical activity on adiponectin in a Japanese population (2020)
  • Author(s): Nishida Y, Hara M, Fuku N, Taguchi N, Horita M, Shimanoe C, Higaki Y, Tanaka K
  • Journal Title: Mitochondrion Volume: 53 Pages: 234-242
  • DOI: 10.1016/j.mito.2020.06.006
  • Peer Reviewed
• [Journal Article] Tuberculosis infection and lung adenocarcinoma : Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women (2020)
  • Author(s): Wong JYY, Zhang H, Hsiung CA, Shiraishi K, ..., Kohno T, Shen H, Chanock SJ, Rothman N, Lan Q.
  • Journal Title: Genomics. Volume: 112 Pages: 1223-1232
  • DOI: 10.1016/j.ygeno.2019.07.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure. (2020)
  • Author(s): Nakano M, Riku Y, Nishioka K, Hasegawa M, Washimi Y, Arahata Y, Takeda A, Horibe K, Yamaoka A, Suzuki K, Tsujimoto M, Li Y, Yoshino H, Hattori N, et al
  • Journal Title: Acta Neuropathol Commun Volume: 8 Pages: 148
  • DOI: 10.1186/s40478-020-01025-1
  • Peer Reviewed / Open Access
• [Journal Article] Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer. (2020)
  • Author(s): Matsuo K, Tanabe K, Hayashi M, Ikeda M, Yasaka M, Machida H, Shida M, Sato K, Yoshida H, Hirasawa T, Imanishi T, Mikami M.
  • Journal Title: Cancers (Basel) Volume: 12 Issue: 9 Pages: E2374
  • DOI: 10.3390/cancers12092374
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Utility of the 3-tier grouping system for survival discriminatory ability in stage IIA cervical cancer. (2020)
  • Author(s): Matsuo K, Nusbaum DJ, Klar M, Matsuzaki S, Grubbs BH, Machida H, Konishi I, Mikami M, Roman LD.
  • Journal Title: Eur J Surg Oncol
  • DOI: 10.1016/j.ejso.2020.06.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims (2020)
  • Author(s): Minako Matsumoto, Sei Harada, Miho Iida, Tomonori Okamura, Toru Takebayashi
  • Journal Title: Journal of Epidemiology
  • DOI: 10.2188/jea.JE20200089
  • Peer Reviewed / Open Access
• [Journal Article] Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level. (2020)
  • Author(s): Tomonobu N, Gede Yoni Komalasari NL, Sumardika IW, Jiang F, Chen Y, Yamamoto KI, Kinoshita R, Murata H, Inoue Y, Sakaguchi M.
  • Journal Title: Chem Biol Interact Volume: 324 Pages: 109085
  • DOI: 10.1016/j.cbi.2020.109085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 遺伝子治療各論 ALS (2020)
  • Author(s): 郭 伸
  • Journal Title: Clinical Neuroscience Volume: 38 Pages: 354-358
• [Journal Article] 筋萎縮性側索硬化症-RNAメタボリズムの観点からみたバイオマーカーおよび治療の開発 (2020)
  • Author(s): 保坂孝史、郭 伸
  • Journal Title: 医学のあゆみ Volume: 273 Pages: 50-56
• [Journal Article] 第128回生涯教育講座 胎児科学をめざして(その2)出雲から展開した研究 (2020)
  • Author(s): 大谷 浩、宇田川 潤、八田 稔久
  • Journal Title: 島根医学 Volume: 40 Pages: 59-68
  • Open Access
• [Journal Article] 妊娠期の環境要因により誘起される生後の脳機能変化 (2020)
  • Author(s): 宇田川 潤
  • Journal Title: Clinical Neuroscience Volume: 38 Pages: 1586-1589
• [Presentation] Association between nutrient patterns and fatty liver index : Baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan. (2021)
  • Author(s): Nguyen Van Tien, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano
  • Organizer: 第31回日本疫学会総会
• [Presentation] Behcet病疾患レジストリ研究により明らかとなった疾患活動性残存の現状 (2021)
  • Author(s): 平原理紗, 桐野洋平, 副島裕太郎, 岳野光洋, 吉見竜介, 藤枝雄一郎, 渥美達也, 東野俊洋, 廣畑俊成, 小林大介, 竹内正樹, 水木信久, 中島秀明
  • Organizer: 第65回日本リウマチ学会総会
• [Presentation] Bidirectional Interactions between obesity/diabetes and Alzheimer's disease. (2021)
  • Author(s): Naoyuki Sato
  • Organizer: The 15th International Symposium on Geriatrics and Gerontology
  • Int'l Joint Research / Invited
• [Presentation] GFI1 Is a Downstream Target of EVI1 in Normal Hematopoiesis. (2021)
  • Author(s): 千葉晶輝
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] 客観的に測定された身体活動と末梢血DNAメチル化の関連 (2021)
  • Author(s): 西田 裕一郎、原 めぐみ、大桃 秀樹、小野 加奈子、清水 厚志、檜垣 靖樹、田口 尚人、島ノ江 千里、堀田 美加子、田中 恵太郎
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] 食事酸負荷とメタボリック症候群との関連 : J-MICC Study (2021)
  • Author(s): 有澤孝吉、釜野桜子、上村浩一、Nguyen Van Tien, J-MICC Study Group
  • Organizer: 第31回日本疫学会総会
• [Presentation] 腎性低尿酸血症1型の新規病因変異である機能低下型スプライシング変異の同定 : 日本人2家系のURAT1/SLC22A12遺伝子の解析より (2021)
  • Author(s): 河村優輔、東野俊英、中山昌喜、清水聖子、四ノ宮成祥、高田龍平、松尾洋孝
  • Organizer: 第54回日本痛風・尿酸核酸学会
• [Presentation] 髄液中リポカリン型プロスタグランジンD合成酵素濃度は特発性正常圧水頭症において放線冠の白質異方性と負に相関する (2021)
  • Author(s): 西田 南海子、下地 啓五、永田 奈々恵、裏出 良博、陣上 直人、奥村 亮介、岡田 務、松本 禎之、石川 正恒、岩崎 孝一、戸田 弘紀
  • Organizer: 第22回日本正常圧水頭症学会
• [Presentation] 成人男性におけるFatty Liver Indexと慢性炎症や動脈スティフネスとの関連 (2021)
  • Author(s): 上村浩一、釜野桜子、有澤孝吉、J-MICC Study徳島地区
  • Organizer: 第91回日本衛生学会学術総会
• [Presentation] 日常の森林浴頻度と不眠症との関連 : J-MICC Study大幸研究 (2021)
  • Author(s): 森田えみ、角谷寛、山田尚登、久保陽子、竹内研時、篠壁多恵、川合紗世、内藤真理子、若井建志
  • Organizer: 第132回日本森林学会大会
• [Presentation] 培養細胞におけるTrefoil factor-1の発現、分泌様式とその細胞増殖、浸潤能への関与 (2021)
  • Author(s): 土橋 洋、中村 律子、椙村 春彦、岡田 真也、潮見 隆之
  • Organizer: 第110回日本病理学会総会
• [Presentation] 病型特異的な痛風関連遺伝子と適応進化の評価 : 臨床診断された痛風症例のゲノムワイド関連解析から (2021)
  • Author(s): 中山昌喜, 中杤昌弘, 河村優輔, 山本 健, 中岡博史, 清水聖子, 小山晃英, ... 栗木清典, 他
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] 母親の出生年による子供のピロリ菌の感染状況と感染要因の検討 (2021)
  • Author(s): 渡邉美貴、中川弘子、細野覚代、永谷照男、番郷子、山田珠樹、鈴木貞夫
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] 慢性胃炎および胃がんに関連する長鎖non-coding RNA結合タンパク質の探索 (2021)
  • Author(s): 北嶋洋志、丸山玲緒、高澤 啓、山本英一郎、新沼 猛、甲斐正広、石黒一也、萬 顕、仲瀬裕志、時野隆至、鈴木 拓
  • Organizer: 第14回日本エピジェネティクス研究会年会
• [Presentation] Establishment of brain bank for human prion diseases. (2020)
  • Author(s): Takao M, Tano M, Inoue T, Shirayoshi T, Kanai M, Furui K, Mihara B.
  • Organizer: American Association of Neuropathologists, Inc. The 96th Annual Meeting
  • Int'l Joint Research
• [Presentation] 12q24 locus affects BMI through alcohol drinking and dietary behaviors (2020)
  • Author(s): Maki Igarashi, Shun Nogawa, Kaoru Kawafune, Tsuyoshi Hachiya, Huijuan Jia, Kyohei Furukawa, Shoko Takahashi, Kenji Saito and Hisanori K
  • Organizer: European Society of Human Genetics
  • Int'l Joint Research
• [Presentation] 25ヒドロキシビタミンD濃度と推定ビタミンD摂取量との関連 (2020)
  • Author(s): 尾崎悦子、前川瑞穂、松井大輔、小山晃英、渡邉功、富田仁美、栗山長門、上原里程
  • Organizer: 第67回日本栄養改善学会
• [Presentation] A dominant variant in DNAJB4 causes myofibrillar myopathy (2020)
  • Author(s): M. Inoue, A. Iida, K. Watanabe, Y. Hosoi, H. Miyajima, S. Hayashi, Y. Inoue, T. Inoue, S. Noguchi, I. Nishino
  • Organizer: The 25th International Annual Virtual Congress of the World Muscle Society
  • Int'l Joint Research
• [Presentation] A new method for detection of neoantigen-specific T cell clones based on clonal expansion using NGS of the TCRβ CDR3 (2020)
  • Author(s): Hidetoshi Sumimoto, Atsushi Takano, Koji Teramoto, and Yataro Daigo
  • Organizer: 第79回 日本癌学会学術総会
• [Presentation] ADにおけるミクログリアのカンナビノイド受容体2型を介した神経炎症調節機構について (2020)
  • Author(s): 祖父江顕、小峯起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二
  • Organizer: 第39回日本認知症学会
• [Presentation] Analyses of mucins in submandibular gland during aging in mice (2020)
  • Author(s): Yamakoshi K, Kameyama A, Nishijima R, Maruyama M.
  • Organizer: 第71回日本電気泳動学会総会
  • Invited
• [Presentation] Analyses of mucins in submandibular gland during aging in mice (2020)
  • Author(s): Yamakoshi K, Kameyama A, Nishijima R, Maruyama M.
  • Organizer: 第43回日本基礎老化学会大会
• [Presentation] Association between mitochondrial and glycolytic impairments in Alzheimer's disease (2020)
  • Author(s): Tatsuhiro Terada, Joseph Therriault, Min Su Peter Kang, Takashi Matsudaira, Tomoyasu Bunai, Tomokazu Obi, Pedro Rosa-Neto, Yasuomi Ouchi
  • Organizer: 第60回日本核医学学会学術総会
• [Presentation] Atherogenic Lipoproteins and Carotid Intimal Medial Thickness Progression over 5 years (2020)
  • Author(s): Ikezaki H, Yokota Y, Ai M, Asztalos BF, Murata M, Hayashi J, Schaefer EJ.
  • Organizer: 88th EAS Congress
  • Int'l Joint Research
• [Presentation] Cancer-associated fibroblasts in metastatic mediastinal lymph nodes serve as a predictor for tumor recurrence in pN2 Non-small cell lung cancer (2020)
  • Author(s): 片岡瑛子
  • Organizer: 1st European Society of Thoracic Surgery Virtual Congress
  • Int'l Joint Research
• [Presentation] Characterization of URST1 as a biomarker and therapeutic target for lung cancer (2020)
  • Author(s): Atsushi Takano, Yohei Miyagi, Yataro Daigo.
  • Organizer: 第79回日本癌学会
• [Presentation] Characterization of URST1 as a cancer biomarker and therapeutic target for lung cancer (2020)
  • Author(s): Atsushi Takano, Yohei Miyagi, Yataro Daigo
  • Organizer: 2020 AACR annual meeting
  • Int'l Joint Research
• [Presentation] Development of gene therapyforamyotrophic lateral sclerosis based on molecular mechanism (2020)
  • Author(s): Kwak S.
  • Organizer: Gene & Cell Therapy Symposium -遺伝子治療・細胞治療シンポジウム
  • Int'l Joint Research / Invited
• [Presentation] Early Death in Patients with Disseminated Intravascular Coagulation during Induction Therapy for Acute Promyelocytic Leukemia : A Nationwide Analysis (2020)
  • Author(s): Kensuke Matsuda, MD1, Taisuke Jo2*, Kazuhiro Toyama, MD, PhD3*, Kumi Nakazaki3*, Hideo Yasunaga, MD, PhD4* and Mineo Kurokawa, MD, PhD3
  • Organizer: 62nd AMERICAN SOCIETY OF HEMATOLOGY ANNUAL MEETING
  • Int'l Joint Research
• [Presentation] EGFR signal induces T cell non-inflamed tumor microenvironment (TME) through suppression of chemokine production from human EGFRmt lung adenocarcinoma (2020)
  • Author(s): Hidetoshi Sumimoto, Atsushi Takano, Koji Teramoto, Yataro Daigo
  • Organizer: American Association of Cancer Research, Annual Meeting 2020
  • Int'l Joint Research
• [Presentation] Examination of effects and the MOA of a new drug candidate, Darinaparsin, on adult T-cell leukemia/lymphoma (ATL) cells (2020)
  • Author(s): Tomohiro Nasu, Aki Tanabe, Toshiki Watanabe, Kaoru Uchimaru, Kazumi Nakano
  • Organizer: 第79回日本癌学会学術集会
• [Presentation] Exploration of pathogenesis for upper motor neuron dysfunction of sporadic ALS employing model mice (2020)
  • Author(s): 日出山拓人、寺本さやか、内藤万希子、齋藤智子、加藤陽久、郭 伸、相澤仁志
  • Organizer: 第43回日本神経科学大会
• [Presentation] Exploring the biological impact of HTLV-1 Rex on dysregulation of the host T-cell splicing machinery (2020)
  • Author(s): Marie Tanaka, Koki Uchida, Toshiki Watanabe, Kaoru Uchimaru, Kazumi Nakano
  • Organizer: 第79回日本癌学会学術集会
• [Presentation] Genetic profiling of aggressive ATL from a nationwide prospective study (2015-2018) (2020)
  • Author(s): Makoto Yamagishi, Yutaka Suzuki, Ayumu Ito, Yuta kuze, Miyuki Kubokawa, Hironobu Katsumata, et al, Takahiro Fukuda, and Kaoru Uchimaru
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Genomic integrity in Alzheimer's disease (2020)
  • Author(s): 間野 達雄
  • Organizer: 第61回 日本神経学会
  • Invited
• [Presentation] Germline and postzygotic de novo mutations implicate neurobiological mechanisms in bipolar disorder (2020)
  • Author(s): Masaki Nishioka, An-a Kazuno, Takumi Nakamura, Naomi Sakai, Tadafumi Kato, Atsushi Takata, and others
  • Organizer: 2020 World Congress of Psychiatric Genetics
  • Int'l Joint Research
• [Presentation] GILT Expression on Microglia in Alzheimer's Disease Brains. (2020)
  • Author(s): 佐藤準一、紀嘉浩、齊藤祐子.
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] Global histone deacetylation is a novel epigenetic alteration in tumor-promoting carcinoma-associated fibroblasts. (2020)
  • Author(s): Mezawa Y, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Maruyama R, Seimiya H, Orimo A
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] GP2 variants are associated with pancreatic cancer risk : from GWAS association to function (2020)
  • Author(s): Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi Ito, Shogo Kikuchi, Keitaro Matsuo, et al.
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] HTLV-1 Rexによる宿主T細胞スプライシング機構制御異常の生物学的影響の検討 (2020)
  • Author(s): 田中 稀瑛、内田 弘毅、渡邉 俊樹、内丸 薫、中野 和民
  • Organizer: 第79回日本癌学会学術集会
• [Presentation] HTLV-1 感染前がんモデルにおけるエピジェネティックなMAPK/ERK経路の活性化 (2020)
  • Author(s): 水池潤、山岸誠、大高時文、中嶋伸介、小林誠一郎、中島誠、新谷奈津美、牧山純也、宇都宮與、田中勇悦、渡邉俊樹、山野嘉久、鈴木穣、藤澤順一、内丸薫
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] HTLV-1感染(症)検査におけるウインドウ・ピリオドについて (2020)
  • Author(s): 相良康子、中村仁美、山本 翠、古賀智英、宮本 彰、島村益広、松山博之、入田和男
  • Organizer: 第68回日本輸血・細胞治療学会学術総会
• [Presentation] HTLV-1感染前がんモデルにおけるエピジェネティックなMAPK/ERK経路の活性化 (2020)
  • Author(s): 水池 潤、山岸 誠、大高 時文、中嶋 伸介、小林 誠一郎、中島 誠、新谷 奈津美、牧山 純也、宇都宮 與、田中 勇悦、渡邉 俊樹、山野 嘉久、鈴木 穣、藤澤 順一、内丸 薫
  • Organizer: 第79回日本癌学会学術集会
• [Presentation] Identification of OASEP1 as a biomarker and therapeutic target for oral cancer (2020)
  • Author(s): Atsushi Takano, 1, 2 Yoshihiro Yoshitake, 3 Masanori Shinohara, 3 Yataro Daigo
  • Organizer: 第64回 日本人類遺伝学会
• [Presentation] Identification of URST1 as a biomarker and a therapeutic target for lung cancer (2020)
  • Author(s): Atsushi Takano, Yohei Miyagi, Yataro Daigo
  • Organizer: 2021 AACR annual meeting
  • Int'l Joint Research
• [Presentation] In vivo association of mitochondrial dysfunction with tau pathology in early Alzheimer's disease (2020)
  • Author(s): Tatsuhiro Terada, Joseph Therriault, Min Su Peter Kang, Tharick Ali Pascoal, Firoza Lussier, Cecile Tissot, Yi-Ting Wang, Yasuomi Ouchi, Pedro Rosa-Neto
  • Organizer: Human Amyloid Imaging 2020
  • Int'l Joint Research
• [Presentation] In vivo association of mitochondrial dysfunction with tau pathology in early Alzheimer's disease (2020)
  • Author(s): Tatsuhiro Terada, Joseph Therriault, Min Su Peter Kang, Tharick Ali Pascoal, Tomokazu Obi, Hideo Tsukada, Yasuomi Ouchi, Pedro Rosa-Neto
  • Organizer: 2020年日本神経科学学会
• [Presentation] In vivo mitochondrial and glycolytic impairments in Alzheimer's disease (2020)
  • Author(s): Tatsuhiro Terada, Tomokazu Obi, Tomoyasu Bunai, Takashi Matsudaira, Hideo Tsukada, Norihiko Kawaguchi, Yasukiyo Araki, Yasuomi Ouchi
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] Mechanisms underlying prostate cancer bone metastasis identified by big data analyses (2020)
  • Author(s): Yuuki Imai
  • Organizer: 47th European Calcified Tissue Society Congress
  • Int'l Joint Research / Invited
• [Presentation] mTORにより制御されるtrefoil factor-1の発現、転写機序と肺癌における意義. (2020)
  • Author(s): 土橋 洋、山田 茂樹、大井 章史、中村 律子、椙村 春彦.
  • Organizer: 第109回日本病理学会総会.
• [Presentation] Novel neuropathologic findings of Gerstmann-Str€aussler-Scheinker disease with P102L mutation. (2020)
  • Author(s): Kawai Y, Takao M, Hashimoto M, Mihara B, Kitamoto T, Yuzuriha T.
  • Organizer: American Association of Neuropathologists, Inc. The 96th Annual Meeting
  • Int'l Joint Research
• [Presentation] Phase II Clinical Trial of Perampanel for Sporadic Amyotrophic Lateral Sclerosis (2020)
  • Author(s): 78. Aizawa H, Kato H, Oba K, Kawahara YT, Okubo Y, Saito T, Naito M, (21名), Matsuyama, Haga, Kwak S
  • Organizer: The 31st International Symposium on MND/ALS
  • Int'l Joint Research
• [Presentation] Prevention of Aging Process : Biomolecular insight, Specific title : A Novel Tumor Suppressor, REIC/Dkk-3 Gene Identified by Our In Vitro Transformation Model of Normal Human Fibroblasts Works as a Potent Therapeutic Anti-tumor Agent (2020)
  • Author(s): Masakiyo Sakaguchi
  • Organizer: National Symposium and Workshop in Anti-Aging Medicine (NASWAAM)
  • Int'l Joint Research / Invited
• [Presentation] S100 family protein : its role in inflammation associated with aging, Specific title : Prevention of cancer metastasis on the basis of identification of novel S100 protein sensor receptors (2020)
  • Author(s): Masakiyo Sakaguchi
  • Organizer: National Symposium and Workshop in Anti-Aging Medicine (NASWAAM)
  • Int'l Joint Research / Invited
• [Presentation] Serum creatinine as a biomarker candidate in patients with hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) (2020)
  • Author(s): Shugo SUWAZONO, Natsumi FUJISAKI
  • Organizer: 第130回沖縄県医師会医学会総会 英語セッション
• [Presentation] Subtype Genome-Wide Meta-Analyses of Clinically-Defined Gout Revealed Multiple Subtype-Specific Gout Loci and Enrichment of Selection Pressure on ABCG2 and ALDH2 (2020)
  • Author(s): Kawamura Y, Nakayama A, Nakatochi M, Yamamoto K, Nakaoka H, ..., Toyoda Y, Takada T, Kamatani Y, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H
  • Organizer: 22th APLAR (Asia-Pacific League of Associations for Rheumatology)
  • Int'l Joint Research
• [Presentation] The correlation between urinary microRNA-21 and renal parameters in patients with IgA nephropathy (2020)
  • Author(s): Akira Araumi, Tsukasa Osaki, Kazunobu Ichikawa, Masafumi Watanabe, Tsuneo Konta
  • Organizer: KIDNEY WEEK 2020 (米国腎臓学会)
  • Int'l Joint Research
• [Presentation] The first patient with pathologically-definite ATXN80S-associated amyotrophic lateral sclerosis (2020)
  • Author(s): Makito Hirano, Shigeo Murayama, Yuishin Izumi, Makoto Samukawa, Tomoyasu Matsubara, Kazumasa Saigoh, Yusaku Nakamura, Susumu Kusunoki
  • Organizer: 第61回日本神経学会
• [Presentation] Towards elucidation of propagation mechanism of tau pathology in Alzheimer's disease (2020)
  • Author(s): 笹栗弘貴
  • Organizer: 第63回日本神経化学会大会
• [Presentation] Transomics analysis using postmortem Schizophrenia brain (2020)
  • Author(s): Fumito Sano
  • Organizer: 日本神経科学学会 第43回日本神経科学大会
• [Presentation] URAT2/OAT10遺伝子の機能低下型ミスセンスSNPは血清尿酸値と痛風のリスクを共に低下させる (2020)
  • Author(s): 河村優輔、東野俊英、清水聖子、中山昌喜、大山恵子、大山博司、清水徹、川口真、高尾幹也、市田公美、四ノ宮成祥、高田龍平、松尾洋孝
  • Organizer: 第53回日本痛風・尿酸核酸学会
• [Presentation] VAV1/PLCG1の協調的変異によるTCRシグナル伝達経路の異常な活性化 (2020)
  • Author(s): 横溝明香里、山岸誠、廣内大成、久世裕太、窪川美雪、宇都宮與、福田隆浩、渡邉俊樹、鈴木穣、内丸薫
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] アルコール代謝遺伝子上のSNPは多彩な食嗜好および食行動と関連する-個別化栄養を目指したニュートリジェネティクス研究- (2020)
  • Author(s): 五十嵐 麻希, 野川 駿, 川舩 かおる, 八谷 剛史, 高橋 祥子, 斉藤 憲司, 賈 慧娟, 加藤 久典
  • Organizer: 第74回日本栄養・食糧学会大会
• [Presentation] アルツハイマー病におけるミトコンドリアと解糖系障害-PETによる検討- (2020)
  • Author(s): 寺田達弘、小尾智一、武内智康、松平敬史、高嶋博嗣、川口典彦、荒木保清、塚田秀夫、尾内康臣
  • Organizer: 第39日本認知症学会学術集会
• [Presentation] アルツハイマー病の病態解明におけるエピゲノムアプローチ (2020)
  • Author(s): 間野 達雄, 岩田 淳
  • Organizer: 第43回 日本分子生物学会年会
  • Invited
• [Presentation] がんの精密医療の加速に必須な基盤としてのコホート・バイオバンク (2020)
  • Author(s): 村上善則、松田浩一、森崎隆幸、桃沢幸秀、渡邊俊樹、醍醐弥太郎、岩井建志
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] ゲノムワイド関連解析による無症候性高尿酸血症患者からの痛風発症に関連する新規遺伝子座の同定 (2020)
  • Author(s): 松尾洋孝、河村優輔、中岡博史、中山昌喜、岡田随象、山本健、清水徹、大山博司、長瀬満夫、清水聖子、高尾幹也、中島宏、中杤昌弘、有澤孝吉、嶽崎俊郎、田中恵太郎、若井建志、久保充明、井ノ上逸朗、四ノ宮成祥
  • Organizer: 第30回日本疫学会学術集会
• [Presentation] シンポジウム4 ブレインバンク/死後脳研究. 統合失調症死後脳におけるタンパク定量解析-ALDH4A1とその発現に影響する遺伝子多型 (2020)
  • Author(s): 長岡敦子 ; 國井泰人 ; 日野瑞城 ; 泉竜太 ; 宍戸理沙 ; 齊ノ内信 ; 那波宏之 ; 柿田明美 ; 矢部博興
  • Organizer: 第42回 日本生物学的精神医学会
• [Presentation] シンポジウム63 精神科ブレインバンク各拠点からの成果と今後の臨床への展望-精神科ブレインバンクへの期待 その4- (2020)
  • Author(s): 國井泰人 ; 長岡敦子 ; 泉竜太 ; 日野瑞城 ; 矢部博興
  • Organizer: 第116回日本精神神経学会学術総会
• [Presentation] ストレスマーカーとしての尿中コルチゾール/コルチゾン比の意義 -スポット尿によるグルココルチコイド類測定の応用可能性- (2020)
  • Author(s): 島ノ江千里
  • Organizer: 第27回日本行動医学会学術総会
• [Presentation] タウELISAの剖検脳での検討 (2020)
  • Author(s): 篠原 充, 田代 善崇, 鈴木 香, 福森 亮雄, 森島 真帆, 村山 繁雄, 里 直行
  • Organizer: 第39回日本認知症学会学術集会
• [Presentation] びまん性大細胞型B細胞リンパ腫の病理組織を用いたプロテオミクスによるバイオマーカー探索 (2020)
  • Author(s): 鶴山竜昭、平塚拓也
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Presentation] メタボリックシンドロームと心理ストレスバイオマーカーとの関連 (2020)
  • Author(s): 島ノ江千里、松本明子、赤尾千穂、原めぐみ、西田裕一郎、堀田美加子、市場正良、田中恵太郎
  • Organizer: 日本衛生学会学術総
• [Presentation] 異所性に発現する異常型電位依存性Ca2+チャネルCav3.2による細胞内Ca2+シグナルへの影響 (2020)
  • Author(s): 廣内大成、山岸誠、中島誠、小林誠一郎、牧山純也、宇都宮 與、渡邉俊樹、鈴木穣、内丸薫
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 危険因子にも着目したアルツハイマー病の病態機構の解明、治療薬開発の研究 (2020)
  • Author(s): 篠原 充
  • Organizer: 第62回日本老年医学会
• [Presentation] 教育コース18 : 臨床病理カンファレンス 症例1 : 40歳代前半に緩徐進行する下腿・肩甲型筋力低下で発症、50歳代から難聴・失語・性格行動変化が続発した1例(臨床) (2020)
  • Author(s): 諏訪園秀吾
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] 血中25ヒドロキシビタミンD濃度の分布と食品摂取との検討 (2020)
  • Author(s): 尾崎悦子、栗山長門、松井大輔、小山晃英、渡邉功、長光玲央、前川瑞穂、富田仁美、糠谷優貴子、吉田玉美、上原里程
  • Organizer: 第79回日本公衆衛生学会
• [Presentation] 原因因子や危険因子に着目した病態解明, 治療薬開発 (2020)
  • Author(s): 篠原充
  • Organizer: 第39回日本認知症学会学術集会
  • Invited
• [Presentation] 口腔機能低下症と歩行速度に関する検討 (2020)
  • Author(s): 糠谷 優貴子(発表代表者), 松井 大輔, 渡邉 功(研究代表者), 栗山 長門, 尾崎 悦子, 小山 晃英, 山本 俊郎, 金村 成智, 上原 里程
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 口腔扁平上皮がんにおける長鎖非コードRNA DLEU1のがん遺伝子的機能の解析. (2020)
  • Author(s): 畠中柚衣, 新沼猛, 西山廣陽, 北嶋洋志, 山本英一郎, 甲斐正広, 関口翔平, 荻和弘, 宮崎晃亘, 鈴木拓.
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 高齢者ドライマウスの原因究明に向けたムチンの分析 (2020)
  • Author(s): 山越貴水, 亀山昭彦, Wai Wai Thet Tin, 渡邉淳, 飯田万由, 西島里咲
  • Organizer: 第71回 日本電気泳動学会総会 シンポジウム
• [Presentation] 死後脳の組織学的解析による精神神経疾患の病的メカニズムの理解 (2020)
  • Author(s): 久保健一郎、吉永怜史、日野瑞城、長岡敦子、泉竜太、宍戸理紗、國井泰人、矢部博興
  • Organizer: 第50回日本神経精神薬理学会年会・42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
  • Invited
• [Presentation] 死後脳を用いた統合失調症Elevated inflammatory biotypeにおける補体C4の関与についての検討 (2020)
  • Author(s): 泉 竜太 ; 宍戸 理紗 ; 日野 瑞城 ; 長岡 敦子 ; 國井 泰人 ; 矢部 博興
  • Organizer: 第42回 日本生物学的精神医学会
• [Presentation] 住民健診受診者における血清microRNAと5年間の血圧変化及び高血圧罹患との関連 (2020)
  • Author(s): 鈴木康司, 藤井亮輔, 山田宏哉, 前田圭介, 坪井良樹, 石原裕也, 橋本修二, 浜島信之
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 住民健診受診者における白血球DNAメチル化率と循環器疾患の死亡リスクとの関連 (2020)
  • Author(s): 坪井良樹, 藤井亮輔, 山田宏哉, 前田圭介, 石原裕也, 橋本修二, 浜島信之, 鈴木康司
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 住民健診受診者における白血球中TXNIP遺伝子のDNAメチル化率と血清脂質との関連 (2020)
  • Author(s): 石原裕也, 前田圭介, 山田宏哉, 藤井亮輔, 坪井良樹, 橋本修二, 浜島信之, 鈴木康司
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 住民健診受診者における白血球中TXNIP遺伝子のDNAメチル化率と血糖変化との関連 (2020)
  • Author(s): 前田圭介, 山田宏哉, 藤井亮輔, 坪井良樹, 石原裕也, 橋本修二, 浜島信之, 鈴木康司
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 食事形態別における栄養素摂取量及び食品摂取頻度の検討 (2020)
  • Author(s): 前川瑞穂、尾﨑悦子、栗山長門、小山晃英、松井大輔、渡邉功、長光玲央、富田仁美、吉田玉美、糠谷優貴子、上原里程
  • Organizer: 第79回日本公衆衛生学会
• [Presentation] 神経細胞特異的な転写制御機構から見える孤発性アルツハイマー病の病態 (2020)
  • Author(s): 間野かがり, 間野達雄, 鈴木穣, 森島真帆, 村山繁雄, 戸田達史, 岩田淳
  • Organizer: 第39回認知症学会
• [Presentation] 迅速簡易な定量的超高感度メチル化DNA解析法の開発とリキッドバイオプシーへの応用 (2020)
  • Author(s): 野村幸男、杉本起一、小林敏之、坂本一博、新井正美、樋野興夫、折茂彰
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 髄液中リポカリン型プロスタグランジンD合成酵素濃度は特発性正常圧水頭症において放線冠の白質異方性と相関する (2020)
  • Author(s): 西田 南海子, 下地 啓五, 永田 奈々恵, 裏出良博, 陣上 直人, 奥村 亮介, 岡田 務, 戸田 弘紀, 松本 禎之, 石川 正恒, 岩崎 孝一
  • Organizer: 日本脳神経外科学会第79回学術総会
• [Presentation] 数理シュミレーションを用いたEphA2/EGFRが制御する肝がん悪性化シグナルの解明 (2020)
  • Author(s): 室井 敦、越川直彦
  • Organizer: 第24回 日本がん分子標的治療学会学術集会
• [Presentation] 成人T細胞白血病・リンパ腫(ATL)細胞に対する新規治療薬Darinaparsinの効果の検討とその作用機序解明の試み (2020)
  • Author(s): 那須 智博、田部 亜季、渡邉 俊樹、内丸 薫、中野 和民
  • Organizer: 第79回日本癌学会学術集会
• [Presentation] 精神疾患ブレインバンクと死後脳研究の現状と課題 (2020)
  • Author(s): 國井泰人
  • Organizer: ヒト剖検脳研究に関する勉強会
  • Invited
• [Presentation] 多重代入法を用いた血清アディポネクチン濃度と遺伝要因、食事要因、季節の関連 (2020)
  • Author(s): 可児美月, 後藤千穂, 栗木清典
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 多層シングルセルプラットフォームによるクローン構造解析とTCR経路変異の生物学的意義の検討 (2020)
  • Author(s): 山岸誠、鈴木穣、窪川美雪、久世裕太、横溝明香里、鈴木絢子、小林誠一郎、中島誠、宇都宮與、森島聡子、福田隆浩、渡邉俊樹、内丸薫
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 多様なリガンドのエンドサイトーシスに関わる分子LRP2の一塩基多型rs2544390は痛風発症と関連する : 日本人男性における痛風とrs2544390のメタ解析 (2020)
  • Author(s): 赤司藍理、中山昌喜、東野俊英、清水聖子、河村優輔、川口真、高尾幹也、高田龍平、市田公美、大山博司、四ノ宮成祥、松尾洋孝
  • Organizer: 第53回日本痛風・尿酸核酸学会
• [Presentation] 大腸がん自然転移マウスモデルを用いたがん幹細胞性規定因子の同定 (2020)
  • Author(s): 青木正博、武藤誠、藤下晃章
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 大腸がん転移抑制因子HNRNPLLはp120-cateninをコードするCTNND1の選択的スプライシングを制御する (2020)
  • Author(s): 青木正博
  • Organizer: 第24回日本がん分子標的治療学会学術集会
• [Presentation] 中高年者における高感度CRPと早期死亡との関係 : JACC Study (2020)
  • Author(s): 木原朋未, 山岸良匡, 磯博康, 玉腰暁子
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 朝食欠食および睡眠時間とメタボリック症候群との関連 : J-MICC Study (2020)
  • Author(s): 釜野桜子、有澤孝吉、Nguyen Van Tien、上村浩一
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] 長期的にラパマイシンを作用させたTsc2欠損腫瘍細胞の増殖におけるHSP27の機能 (2020)
  • Author(s): 北野隆之、西川桂子、折茂彰、樋野興夫、小林敏之
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 転移性膵癌におけるHOXA遺伝子座のlincRNA発現異常 (2020)
  • Author(s): 新沼猛, 北嶋洋志, 山本英一郎, 甲斐正広, 鈴木拓.
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 統合失調症モデル動物研究と展望 ; 幻聴の再現可能性 (2020)
  • Author(s): 那波宏之
  • Organizer: 第116回日本精神神経学会学術総会
  • Invited
• [Presentation] 統合失調症脳病態における脂質シグナル伝達の意義-死後脳研究 (2020)
  • Author(s): 國井泰人 ; 松本純弥 ; 泉竜太 ; 長岡敦子 ; 日野瑞城 ; 赤津裕康 ; 橋詰良夫 ; 齊ノ内信 ; 柿田明美 ; 矢部博興
  • Organizer: 第116回日本精神神経学会学術総会
• [Presentation] 日本人における身長と大動脈疾患死亡との関連 : the JACC study (2020)
  • Author(s): 高田碧, 山岸良匡, 磯博康, 玉腰暁子
  • Organizer: 第56回日本循環器病予防学会学術総会
• [Presentation] 乳腺癌関連線維芽細胞においてRUNX3の発現は炎症性サイトカインの発現を抑制することで腫瘍抑制的に働く (2020)
  • Author(s): 小山侑、目澤義弘、伊藤恭彦、小山拓洋、醍醐弥太郎、高野淳、宮城洋平、横瀬智之、山下年成、菅原圭亮、樋野興夫、丸山玲緒、片倉朗、折茂彰
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 尿中cortisol/cortisone比と精神健康との関連 : J-MICC study SAGA (2020)
  • Author(s): 島ノ江 千里、松本 明子、赤尾 千穂、原 めぐみ、西田 裕一郎、南里 妃名子、堀田 美加子、山田 陽介、檜垣 靖樹、田中 恵太郎
  • Organizer: 第30回日本疫学会学術総会
• [Presentation] 肥満に対するn-6 PUFA摂取と赤血球膜割合、遺伝要因の関連 : the J-MICC Sakura Diet Studyの横断的研究 (2020)
  • Author(s): 袴田菜月, 根津のあ, 古郡かすみ, 可児美月, 後藤千穂, 栗木清典
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 肥満に対するアミノ酸摂取量と腸内細菌叢の関連 : 四季食事調査の横断的検討 (2020)
  • Author(s): 根津のあ, 袴田菜月, 古郡かすみ, 可児美月, 後藤千穂, 栗木清典
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 肥満に対するアルコール摂取量と遺伝要因の関連 : the J-MICC Sakura Diet Studyの横断的研究 (2020)
  • Author(s): 古郡かすみ, 根津のあ, 袴田菜月, 可児美月, 五十嵐麻希, 後藤千穂, 栗木清典
  • Organizer: 第79回日本公衆衛生学会総会
• [Presentation] 非小細胞肺がんにおける可溶性PD-L1とM2マクロファージ (2020)
  • Author(s): 寺本晃治、五十嵐知之、住本秀敏、醍醐弥太郎
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 母親の妊娠期間中の特性および3歳児の食習慣と児の体格との関連 (2020)
  • Author(s): 釜野 桜子
  • Organizer: 第79回日本公衆衛生学会学術総会
• [Presentation] 慢性胃炎および胃がんに関連する長鎖non-coding RNAの同定 (2020)
  • Author(s): 北嶋洋志、丸山玲緒、高澤 啓、新沼 猛、山本英一郎、甲斐正広、時野隆至、小山内誠、仲瀬裕志、鈴木 拓
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] 慢性胃炎および胃がんに関連する長鎖non-coding RNAの同定 (2020)
  • Author(s): 北嶋洋志、丸山玲緒、高澤 啓、新沼 猛、山本英一郎、甲斐正広、時野隆至、小山内誠、仲瀬裕志、鈴木 拓
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 慢性胃炎および胃がんに関連する長鎖non-coding RNAの同定. (2020)
  • Author(s): 北嶋洋志, 丸山玲緒, 高澤啓, 新沼猛, 山本英一郎, 甲斐正広, 時野隆至, 小山内誠, 仲瀬裕志, 鈴木拓.
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 頸動脈内膜中膜複合体の肥厚進展予測因子としてのsmall dense LDLコレステロールの有用性 (2020)
  • Author(s): 池崎裕昭、横田裕哉、藍 真澄、Asztalos BF、村田昌之、林 純、Schaefer EJ
  • Organizer: 第117回 日本内科学会総会・講演会
• [Presentation] 頸動脈内膜中膜複合体の肥厚進展予測因子としてのsmall dense LDLコレステロールの有用性 (2020)
  • Author(s): 池崎裕昭、横田裕哉、藍 真澄、Asztalos BF、村田昌之、古庄憲浩、林 純、Schaefer EJ
  • Organizer: 第20回 日本病院総合診療医学会学術総会
• [Book] Precision medicine (2020)
  • Author(s): 朝倉暢彦、室井 敦、越川直彦、鈴木 貴
  • Total Pages: 96
  • Publisher: 北隆館
• [Book] がん生物学 イラストレイテッド (2020)
  • Author(s): 室井 敦、星野大輔、清木元治、越川直彦
  • Total Pages: 504
  • Publisher: 羊土社
• [Book] 外科病理学(第5版) (2020)
  • Author(s): 長嶋洋治(分担執筆)
  • Total Pages: 1892
  • Publisher: 文光堂
• [Remarks] 千葉大学社会精神保健教育研究センター
  • URL: http://www.m.chiba-u.ac.jp/class/shakai/jp/byoutai/index.html
• [Remarks] 精神疾患ブレインバンク・DNAバンクホームページ
  • URL: http://www.fmu-bb.jp/
• [Remarks] 順天堂大学大学院 臨床腫瘍学
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/rinsho_shuyo/k4.html
• [Remarks] 慶應義塾大学医学部百寿総合研究センター公式ページ
  • URL: http://www.keio-centenarian.com/
• [Remarks] 横浜市立大学 大学院医学研究科微生物学・分子生体防御学教室ホームページ
  • URL: http://www-user.yokohama-cu.ac.jp/~saikin/
• [Remarks] 浜松医科大学細胞分子解剖学講座ホームページ
  • URL: https://www.hama-med.ac.jp/mt/setou/ja/prize/
• [Remarks] J-MICC STUDY
  • URL: http://www.jmicc.com
• [Remarks] 滋賀医科大学薬理学講座ホームページ
  • URL: http://www.shiga-med.ac.jp/pharm/
• [Remarks] 高島コホート研究ホームページ
  • URL: https://www.shiga-med.ac.jp/hqcera/project/takashima_study/index.html
• [Remarks] 京都大学循環器内科分子病態学研究グループホームページ
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/sentan-bunshi/
• [Remarks] 大阪大学大学院薬学研究科 神経薬理学分野ホームページ
  • URL: http://molpharm.umin.jp/index.html
• [Remarks] 岩手医科大学 医歯薬総合研究所 西塚哲研究室
  • URL: http://www.nishizukalab.org/?lang=ja"
• [Remarks] 福島県立医科大学 医学部 基礎病理学講座ホームページ
  • URL: https://www.fmu.ac.jp/home/p2/index.html
• [Remarks] 慶應義塾大学衛生学公衆衛生学教室ホームページ
  • URL: https://keiopublichealth.jp/research/research04.html
• [Remarks] コホート・生体試料支援プラットフォーム ホームページ
  • URL: http://cohort.umin.jp/
• [Remarks] 東京医科大学 神経分子病態学(遺伝子治療研究所)寄附講座 特任教授 郭 伸ホームページ
  • URL: http://square.umin.ac.jp/teamkwak/index.html
• [Remarks] 理研CBS タンパク質構造疾患研究チーム ホームページ
  • URL: http://motomasalab.riken.jp
• [Remarks] 愛媛大学プロテオサイエンスセンター病態生理解析部門 ホームページ
  • URL: https://www.m.ehime-u.ac.jp/school/imailab
• [Remarks] 佐賀大学医学部社会医学講座予防医学分野/J-MICC Study佐賀フィールド
  • URL: https://prevent.med.saga-u.ac.jp/jmicc/
• [Remarks] 熊本大学ヒトレトロウイルス学共同研究センター 佐藤研究室ホームページ
  • URL: http://kumamoto-u-jrchri.jp/satou/
• [Remarks] 生命科学連携推進協議会 YouTubeチャンネル コホート・生体試料支援プラットフォームの支援内容紹介動画掲載
  • URL: https://www.youtube.com/channel/UCNEXa8q02WqZbGIwD110u4Q
• [Patent(Industrial Property Rights)] 甲状腺濾胞癌特異的マーカー (2021)
  • Inventor(s): 軸薗 智雄、石橋 宰
  • Industrial Property Rights Holder: 学校法人日本医科大学公立大学法人大阪
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2021-57814