コホート・生体試料支援プラットフォーム

2021 Fiscal Year Annual Research Report

• Project/Area Number: 16H06277
• Principal Investigator: 村上 善則 東京大学, 医科学研究所, 教授
• Project Period (FY): 2016 – 2021
• Keywords: 生体試料支援 / 健常人コホート / ブレインバンク / 最先端解析技術支援 / 臨床検体

Outline of Annual Research Achievements

①総括支援活動 : CoBiAの若手支援研究成果発表会をオンライン開催し、各支援機能の説明、教育講演、18名の若手研究者成果発表と情報交換を行った(3/14)。また国内のバンク連携を図った。さらにBioJapan2022, 日本人類遺伝学会等への出展、関連分野の科研費取得者へのダイレクトメール等により、研究支援の広報、周知に努めた。また、新型コロナウイルス感染に対する研究者支援を継続した。
②コホートによるバイオリソース支援活動 : 今年度はコホート研究のデータ・生体試料の提供(がん早期診断マーカー検証含む)、大規模バイオデータの解析などにより、241件の研究支援を実施した。支援基盤の整備では、主要な基盤であるJ-MICC研究において、従来の死亡・がん罹患追跡データに加え、第二次調査のデータも整備した。さらに共同研究の機会も有効活用し、SNPアレイによるタイピングデータの増加を図った。
③ブレインリソースの整備と活用支援 : 関西拠点の拡充のために、大阪大学に創設したブレインバンク部門を強化し、広島大学、徳島大学拠点の拡充を行った。東京都健康長寿医療センター高齢者ブレインバンクホームページのアップデートを行い、リソースの品質管理、診断レベルの向上に貢献した。また、ブレインバンク生前ドナー登録システムを全国レベルに展開する努力を通じて、コロナ禍による剖検数の減少に歯止めをかけた。
④生体試料支援活動 : 347課題に生体機能分子の高感度解析・技術支援と共同研究ネットワーク構築支援を実施した。172課題にがん関連試料・情報を提供し、病理形態解析支援を実施した。19,782試料(血清、リンパ球、凍結・パラフィン包埋組織、DNA)を収集し、3,176試料を提供した。解析・連携構築支援、試料収集・提供支援、コロナ禍の研究支援体制を強化し、学会・講演会を通じたヒト生体試料の活用研究の普及・啓発を実施した。

Research Progress Status

令和3年度が最終年度のため記入しない

Strategy for Future Research Activity

令和3年度が最終年度のため記入しない

Research Products

• [Journal Article] A genome-wide association study on adherence to low-carbohydrate diets in Japanese. (2022)
  • Author(s): Nakamura Y, Tamura T, Narita A, Shimizu A, Sutoh Y, Takashima N, Matsui K, .... Kuirki K, et al.
  • Journal Title: Eur J Clin Nutr.
  • DOI: 10.1038/s41430-022-01090-w
  • Peer Reviewed
• [Journal Article] A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility. (2022)
  • Author(s): Chang SJ, Wakai K, Matsuo H, et al.
  • Journal Title: Human Cell Volume: 35 Pages: 767-770
  • DOI: 10.1007/s13577-021-00665-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An autopsied case report of spastic paraplegia with thin corpus callosum carrying a novel mutation in the SPGII gene : widespread degeneration with eosinophilic inclusions (2022)
  • Author(s): Mika Hayakawa, Tomoyasu Matsubara, Yoko Mochizuki, Chisen Takeuchi, Motoyuki Minamitani, Masayuki Imai, Kenjiro Kosaki, Tomio Arai, Shigeo Murayama
  • Journal Title: BMC Neurology Volume: 22 Pages: 2
  • DOI: 10.1186/s12883-021-02514-z
  • Peer Reviewed / Open Access
• [Journal Article] An autopsy case of Alzheimer's disease with amygdala-predominant Lewy pathology presenting with frontotemporal dementia-like psychiatric symptoms. (2022)
  • Author(s): Beck G, Shigenobu K, Ukon K, Yamashita R, Yonenobu Y, Morii E, Hasegawa M, Ikeda M, Murayama S, Mochizuki H.
  • Journal Title: Neuropathology Volume: 42 Pages: 147-154
  • DOI: 10.1111/neup.12786
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between germline pathogenic variants and breast cancer risk in Japanese women : the HERPACC study (2022)
  • Author(s): Kasugai Y, Kohmoto T, Taniyama Y, Koyanagi YN, Usui Y, Iwase M, Oze I, Yamaguchi R, Ito H, Imoto I, Matsuo K.
  • Journal Title: Cancer Sci Volume: 113 Pages: 1451-1462
  • DOI: 10.1111/cas.15312
  • Peer Reviewed / Open Access
• [Journal Article] Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women. (2022)
  • Author(s): Koga K, Hara M, Shimanoe C, Nishida Y, Furukawa T, Iwasaka C, Tanaka K, ..., Kuriki K, et al.
  • Journal Title: Sci Rep. Volume: 12 Issue: 1 Pages: 291
  • DOI: 10.1038/s41598-021-04324-2
  • Peer Reviewed / Open Access
• [Journal Article] Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women : The Japan Multi-Institutional Collaborative Cohort Study. (2022)
  • Author(s): Matsunaga T, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Nagayoshi M, Tamura T, ... Kuriki K, et al.
  • Journal Title: PLoS One. Volume: 17 Issue: 1 Pages: e0262252
  • DOI: 10.1371/journal.pone.0262252
  • Peer Reviewed / Open Access
• [Journal Article] Autopsy Validation of the Diagnostic Accuracy of 123 I-Metaiodobenzylguanidine Myocardial Scintigraphy for Lewy Body Disease (2022)
  • Author(s): Tomoyasu Matsubara, Masashi Kameyama, Noriko Tanaka, Renpei Sengoku, Makoto Orita, Ko Furuta, Atsushi Iwata, Tomio Arai, Hirofumi Maruyama, Yuko Saito, Shigeo Murayama
  • Journal Title: Neurology Volume: 98 Pages: e1648-e1659
  • DOI: 10.1212/WNL.0000000000200110
  • Peer Reviewed / Open Access
• [Journal Article] Claudins and Gastric Cancer : An Overview. (2022)
  • Author(s): Hashimoto I, Oshima T
  • Journal Title: Cancers Volume: 14 Issue: 2 Pages: 290
  • DOI: 10.3390/cancers14020290
  • Peer Reviewed / Open Access
• [Journal Article] Dkk3/REIC deficiency impairs spermiation, sperm fibrous sheath integrity and the sperm motility of mice (2022)
  • Author(s): Xue R, Lin W, Fujita H, Sun J, Kinoshita R, Ochiai K, Futami J, Watanabe M, Ohuchi H, Sakaguchi M, Tang Z, Huang P, Nasu Y, Kumon H
  • Journal Title: Genes Volume: 13 Pages: 285
  • DOI: 10.3390/genes13020285
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DNA methylation level of the gene encoding thioredoxin-interacting protein in peripheral blood cells is associated with metabolic syndrome in the Japanese general population (2022)
  • Author(s): Yamazaki M, Yamada H, Munetsuna E, Maeda K, Ando Y, Mizuno G, Fujii R, Tsuboi Y, Ohashi K, Ishikawa H, Hashimoto S, Hamajima N, Suzuki K.
  • Journal Title: Endocrine Journal Volume: 69 Pages: 319-326
  • DOI: 10.1507/endocrj.EJ21-0339
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the interaction between physical activity and estimated macronutrient intake on HbAlc : population-based cross-sectional and longitudinal studies. (2022)
  • Author(s): Furukawa T, Nishida Y, Hara M, Shimanoe C, Koga K, Iwasaka C, Higaki Y, ..., Kuriki K, et al.
  • Journal Title: BMJ Open Diabetes Res Care. Volume: 10 Issue: 1 Pages: e002479
  • DOI: 10.1136/bmjdrc-2021-002479
  • Peer Reviewed / Open Access
• [Journal Article] Enhancement of LTD-like plasticity by associative pairing of quadripulse magnetic stimulation with peripheral nerve stimulation. (2022)
  • Author(s): Wiratman W, Murakami T, Tiksnadi A, Kobayashi S, Hanajima R, Ugawa Y.
  • Journal Title: Clin Neurophysiol Volume: 138 Pages: 9-17
  • DOI: 10.1016/j.clinph.2022.03.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic-epidemiological analysis of hypouricemia from 4,993 Japanese on nonfunctional variants of URAT1/SLC22A12 gene (2022)
  • Author(s): Nakayama A, Kawamura Y, Toyoda Y, .., Kubo Y, Imakiire T, Iwasawa S, Nakashima H, Tsunoda M, Ito K, Kumagai H, Takada T, Ichida K, Shinomiya N, Matsuo H.
  • Journal Title: Rheumatology Volume: 61 Pages: 1276-1281
  • DOI: 10.1093/rheumatology/keab545
  • Peer Reviewed / Open Access
• [Journal Article] Hornerin deposits in neuronal intranuclear inclusion disease : direct identification of proteins with compositionally biased regions in inclusions. (2022)
  • Author(s): Park H, Yamanaka T, Toyama Y, Fujita A, Doi H, Nirasawa T, Murayama S, Matsumoto N, Shimogori T, Ikegawa M, Haltia MJ, Nukina N.
  • Journal Title: Acta Neuropathol Commun. Volume: 10 Pages: 28
  • DOI: 10.1186/s40478-022-01333-8
  • Peer Reviewed / Open Access
• [Journal Article] Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma. (2022)
  • Author(s): Arnaldo N S Silva, Yuichi Saito, Takaki Yoshikawa, Takashi Oshima, William Allum, Matthew G Nankivell, Gordon Hutchins, David Cunningham, Heike I Grabsch.
  • Journal Title: The British journal of surgery Volume: 109 Issue: 3 Pages: 291-297
  • DOI: 10.1093/bjs/znab460
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Investigation of miRNA expression profiles using cohort samples reveals potential early detectability of colorectal cancers by serum miR-26a-5p before clinical diagnosis (2022)
  • Author(s): Hishida A, Yamada H, Ando Y, Okugawa Y, Shiozawa M, Miyagi Y, Daigo Y, Toiyama Y, Shirai Y, Tanaka K, Takeuchi K, Wakai K, et al.
  • Journal Title: Oncology Letters Volume: 23 Issue: 3 Pages: 87
  • DOI: 10.3892/ol.2022.13207
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1 (2022)
  • Author(s): Komaki K, Takano T, Sato Y, Asada A, Ikeda S, Yamada K, ...., Murayama S, ...., Fukuda M, Hisanaga SI.
  • Journal Title: J Biochem Volume: 170 Pages: 729-738
  • DOI: 10.1093/jb/mvab094.PMID:34523681
  • Peer Reviewed
• [Journal Article] New insights into the genetic contribution of ALDH2 rs671 in pancreatic carcinogenesis : Evaluation by mediation analysis (2022)
  • Author(s): Koyanagi YN, Oze I, Kasugai Y, Kawakatsu Y, Taniyama Y, Hara K, Shimizu Y, Imoto I, Ito H, Matsuo K.
  • Journal Title: Cancer Sci Volume: 113 Pages: 1441-1450
  • DOI: 10.1111/cas.15286
  • Peer Reviewed / Open Access
• [Journal Article] Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients (2022)
  • Author(s): Fujiwara Y, Kabuta C, Sano T, Murayama S, Saito Y, Kabuta T.
  • Journal Title: Neurochem Int Volume: 152 Pages: 105243
  • DOI: 10.1016/j.neuint.2021.105243
  • Peer Reviewed
• [Journal Article] The association of reproductive history with hypertension and obesity according to menopausal status : the J-MICC Study. (2022)
  • Author(s): Ohashi M, Miura K, Takashima N, Kadota A, Saito Y, Tsuji S, Murakami T, ... Kuriki K, et al.
  • Journal Title: Hypertens Res. Volume: 45 Issue: 4 Pages: 708-714
  • DOI: 10.1038/s41440-021-00820-0
  • Peer Reviewed
• [Journal Article] Unique Lewy pathology in myotonic dystrophy type 1. (2022)
  • Author(s): Sano T, Kawazoe T, Shioya A, Mori-Yoshimura M, Oya Y, Maruo K, Nishino I, Hoshino M, Murayama S, Saito Y.
  • Journal Title: Neuropathology Volume: 42 Pages: 104-116
  • DOI: 10.1111/neup.12790
  • Peer Reviewed
• [Journal Article] Weak shoulder and arm sparing signs in amyotrophic lateral sclerosis. (2022)
  • Author(s): Hamada Y, Kanbayashi T, Takahashi K, Kamiya H, Kobayashi S, Sonoo M.
  • Journal Title: Muscle Nerve Volume: 65 Issue: 3 Pages: 311-316
  • DOI: 10.1002/mus.27480
  • Peer Reviewed
• [Journal Article] 胎生期環境と精神神経発達 (2022)
  • Author(s): 宇田川 潤
  • Journal Title: BIO Clinica Volume: 37 Pages: 20-23
• [Journal Article] Plasmalogen Deficiency and Overactive Fatty Acid Elongation Biomarkers in Serum of Breast Cancer Patients Pre- and Post-Surgery-New Insights on Diagnosis, Risk Assessment, and Disease Mechanisms. (2021)
  • Author(s): Tomida S, Goodenowe DB, Koyama T, Ozaki E, Kuriyama N, Morita M, Yamazaki Y, Sakaguchi K, Uehara R, Taguchi T.
  • Journal Title: Cancers Volume: 13 Pages: 4170
  • DOI: 10.3390/cancers13164170
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of Tumor Antigens in Ovarian Cancers Using Local and Circulating Tumor-Specific Antibodies. (2021)
  • Author(s): Da Gama Duarte J, Quigley LT, Young AR, Hayashi M, Miyazawa M, Lopata A, Mancuso N, Mikami M, Behren A, Meeusen E.
  • Journal Title: Int J Mol Sci Volume: 22 Issue: 20 Pages: 11220
  • DOI: 10.3390/ijms222011220
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Survival and reproductive outcomes after fertility-sparing surgery performed for borderline epithelial ovarian tumor in Japanese adolescents and young adults : Results of a retrospective nationwide study. (2021)
  • Author(s): Kuji S, Harada M, Yoshioka N, Kajiyama H, Satoh T, Mikami M, Shozu M, Enomoto T, Osuga Y, Suzuki N.
  • Journal Title: J Obstet Gynaecol Res Volume: 48 Issue: 3 Pages: 806-816
  • DOI: 10.1111/jog.15131
  • Peer Reviewed / Open Access
• [Journal Article] A genome-wide association study on meat consumption in a Japanese population : the Japan Multi-Institutional Collaborative Cohort study. (2021)
  • Author(s): Nakamura Y, Narita A, Sutoh Y, Imaeda N, Goto C, Matsui K, Takashima N, ....
  • Journal Title: J Nutr Sci. Volume: 10 Pages: e61
  • DOI: 10.1017/jns.2021.49
  • Peer Reviewed / Open Access
• [Journal Article] A novel case of concurrent occurrence of demyelinating-polyneuropathy-causing PMP22 duplication and SOX10 gene mutation producing severe hypertrophic neuropathy. (2021)
  • Author(s): Matsuda N, Ootsuki K, Kobayashi S, Nemoto A, Kubo H, Usami S, Kanai K.
  • Journal Title: BMC Neurol Volume: 21 Pages: 243
  • DOI: 10.1186/s12883-021-02256-y
  • Peer Reviewed / Open Access
• [Journal Article] A novel LAMC2 fusion protein has tumor promoting properties in ovarian carcinoma (2021)
  • Author(s): Daisuke, Hoshino ; Katoh, Hisamori ; Fukumura, Kazuhiro ; Mayeda, Akila ; Miyagi, Yohei ; Seiki, Motoharu ; Koshikawa, Naohiko
  • Journal Title: Cancer Science Volume: 112 Pages: 4957-4967
  • DOI: 10.1111/cas.15149
  • Peer Reviewed / Open Access
• [Journal Article] A Personal Breast Cancer Risk Stratification Model Using Common Variants and Environmental Risk Factors in Japanese Females (2021)
  • Author(s): Oze I, Ito H, Kasugai Y, Yamaji T, Kijima Y, Ugai T, Kasuga Y, Ouellette TK, Taniyama Y, Koyanagi YN, Imoto I, Tsugane S, Koriyama C, Iwasaki M, Matsuo K.
  • Journal Title: Cancers Volume: 13 Pages: 3796
  • DOI: 10.3390/cancers13153796
  • Peer Reviewed / Open Access
• [Journal Article] A Proposal for Practical Diagnosis of Renal Hypouricemia : Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals (2021)
  • Author(s): Kawamura Y, Nakayama A, .., Takeuchi K, Takada T, Tsunoda M, Arisawa K, Takezaki T, Tanaka K, Ichida K, Wakai K, Shinomiya N, Matsuo H.
  • Journal Title: Biomedicines Volume: 9 Pages: 1012
  • DOI: 10.3390/biomedicines9081012
  • Peer Reviewed / Open Access
• [Journal Article] A randomized phase III trial of adjuvant chemotherapy versus concurrent chemoradiotherapy for postoperative cervical cancer : Japanese Gynecologic Oncology Group study (JGOG1082) (2021)
  • Author(s): Furusawa A, Takekuma M, Mori K, Usami T, Kondo E, Nishio S, Nishino K, Miyamoto Y, Yoshimura R, Watanabe M, Mikami M, Enomoto T.
  • Journal Title: Int J Gynecol Cancer Volume: 31 Issue: 4 Pages: 623-626
  • DOI: 10.1136/ijgc-2020-002344
  • Peer Reviewed / Open Access
• [Journal Article] A retrospective assessment of the safety and efficacy of laparoscopic radical hysterectomy in Japan during the early years following its introduction : a Japanese Gynecologic Oncology Group study (JGOG1081S) (2021)
  • Author(s): Kobayashi E, Kanao H, Takekuma M, Nishio S, Kojima-Chiba A, Tozawa A, Yamaguchi S, Takeshima N, Nakatani E, Mikami M.
  • Journal Title: Int J Clin Oncol Volume: 26 Issue: 2 Pages: 417-428
  • DOI: 10.1007/s10147-020-01799-3
  • Peer Reviewed / Open Access
• [Journal Article] A retrospective study for investigating the outcomes of endometrial cancer treated with radiotherapy. (2021)
  • Author(s): Sakai K, Yamagami W, Machida H, Ebina Y, Kobayashi Y, Tabata T, Kaneuchi M, Nagase S, Enomoto T, Aoki D, Mikami M.
  • Journal Title: Int J Gynaecol Obstet Volume: 156 Issue: 2 Pages: 262-269
  • DOI: 10.1002/ijgo.13725
  • Peer Reviewed / Open Access
• [Journal Article] A Sensitive New Assay System for Serum Wisteria floribunda Agglutinin-reactive Ceruloplasmin that Distinguishes Ovarian Clear Cell Carcinoma from Endometrioma. (2021)
  • Author(s): Sogabe M, Kojima S, Kaya T, Tomioka A, Kaji H, Sato T, Chiba Y, Shimizu A, Tanaka N, Suzuki N, Hayashi I, Mikami M, Togayachi A, Narimatsu H.
  • Journal Title: Anal Chem Volume: 94 Issue: 5 Pages: 2476-2484
  • DOI: 10.1021/acs.analchem.1c04302
  • Peer Reviewed / Open Access
• [Journal Article] Acute retrobulbar optic neuritis with anti-myelin oligodendrocyte glycoprotein antibody-associated disease complicated with microscopic polyantitis : a case report. (2021)
  • Author(s): Asano T, Saito Y, Matsuoka N, Temmoku J, Fujita Y, Hattori K, Kobayashi S, Ojima A, Takahashi T, Matsumoto H, Yashiro-Furuya M, Sato S, Kobayashi H, Watanabe H, Yano K, Sasajima T, Fujihara K, Migita K.
  • Journal Title: Medicine Volume: 100 Issue: 16 Pages: e24889
  • DOI: 10.1097/MD.0000000000024889
  • Peer Reviewed
• [Journal Article] Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominentiron accumulation in the frontal operculum and precentral gyrus. (2021)
  • Author(s): Mitani TT, Beck G, Kido K, Yamashita R, Yonenobu Y, Ogawa T, Saeki C, Okuno T, Nagano S, Morii E, Hasegawa M, Saito Y, Murayama S, Mochizuki H.
  • Journal Title: Neuropathology Volume: 41 Pages: 324-331
  • DOI: 10.1111/neup.12763
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An autopsy report of a familial amyotrophic lateral sclerosis case carrying VCP Arg487His mutation with a unique TDP-43 proteinopathy (2021)
  • Author(s): Matsubara T, Izumi Y, Oda M, Takahashi M, Maruyama H, Miyamoto R, Watanabe C, Tachiyama Y, Morino H, Kawakami H, Saito Y, Murayama S.
  • Journal Title: Neuropathology Volume: 41 Pages: 118-126
  • DOI: 10.1111/neup.12710
  • Peer Reviewed
• [Journal Article] An Extensive-stage Small-cell Lung Cancer Case With Preexisting Lambert-Eaton Myasthenic Syndrome Successfully Treated With an Immune Checkpoint Inhibitor (2021)
  • Author(s): Tadashi Sakaguchi, Yasumasa Kokubo, Kazuki Furuhashi, Yuki Nakamura, Yuta Suzuki, Kentaro Ito, Kentaro Fujiwara, Yoichi Nishii, Osamu Taguchi, Osamu Hataji
  • Journal Title: Clin Lung Cancer
  • DOI: 10.1016/j.cllc.2021.09.001
  • Peer Reviewed / Open Access
• [Journal Article] An immigrant family with Kii Amyotrophic lateral sclerosis/parkinsonism-dementia complex (2021)
  • Author(s): Y Kokubo, S Morimoto, R Sasaki, M Hasegawa, H Ishiura, S Tsuji, M Yoshida, N Yamazoe, M Miyazaki, S Kuzuhara
  • Journal Title: Neurol Sci Volume: 43 Pages: 1423-1425
  • DOI: 10.1007/s10072-021-05737-7
  • Peer Reviewed / Open Access
• [Journal Article] An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate (2021)
  • Author(s): Nakatochi M, Toyoda Y, Kanai M, Nakayama A, Kawamura Y, Hishida A, Mikami H, Matsuo K, Takezaki T, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H, et al.
  • Journal Title: Rheumatology Volume: 60 Pages: 4430-4432
  • DOI: 10.1093/rheumatology/keab404
  • Peer Reviewed / Open Access
• [Journal Article] Aquaporin-4-antibody-positive neuromyelitis optica spectrum disorder in a patient with Charcot-Marie-Tooth disease type 1A. (2021)
  • Author(s): Hamada Y, Takahashi K, Kanbayashi T, Hatanaka Y, Kobayashi S, Sonoo M.
  • Journal Title: Intern Med Volume: 60 Issue: 1 Pages: 1611-1614
  • DOI: 10.2169/internalmedicine.6153-20
  • Peer Reviewed
• [Journal Article] Association between C-Reactive Protein Levels and Functional Disability in the General 01der- Population : The Takashima Study (2021)
  • Author(s): Naoyuki Takashima, Yasuyuki Nakamura, Naoko Miyagawa, Aya Kadota, Yoshino Saito, Kenji Matsui, Katsuyuki Miura, Hirotsugu Ueshima and Yoshikuni Kita
  • Journal Title: J Atheroscler Thromb
  • DOI: 10.5551/jat.63323
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between frequency of snacking and all-cause mortality among community-dwelling young-old adults : An age-specific prospective cohort study (2021)
  • Author(s): Tohru Kobayashi, Wenjing Zhao, Shigekazu Ukawa, Kenji Wakai, Kazuyo Tsushita, Takashi Kawamura, Masahiko Ando, Akiko Tamakoshi
  • Journal Title: Geriatr Gerontol Int Volume: 21 Issue: 8 Pages: 697-704
  • DOI: 10.1111/ggi.14209
  • Peer Reviewed
• [Journal Article] Association between hospital treatment volume and survival of women with gynecologic malignancy in Japan : a JSOG tumor registry-based data extraction study. (2021)
  • Author(s): Machida H, Matsuo K, Oba K, Aoki D, Enomoto T, Okamoto A, Katabuchi H, Nagase S, Mandai M, Yaegashi N, Yamagami W, Mikami M.
  • Journal Title: J Gynecol Oncol Volume: 33 Issue: 1 Pages: e3
  • DOI: 10.3802/jgo.2022.33.e3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between long-term alcohol consumption and insomnia symptoms in civil servants : Aichi Workers' Cohort Study. (2021)
  • Author(s): Terabe M, Kitajima T, Ota A, Yatsuya H, Iwata N.
  • Journal Title: Fujita Med J
  • Peer Reviewed / Open Access
• [Journal Article] Association between stress coping strategy and functional disability in the general older adult population : the Takashima study. (2021)
  • Author(s): Naoyuki Takashima, Yasuyuki Nakamura, Naoko Miyagawa, Aya Kadota, Sachiko Tanaka-Mizuno, Kenji Matsui, Katsuyuki Miura, Hirotsugu Ueshima, Yoshikuni Kita
  • Journal Title: Gerontology
  • DOI: 10.1159/000519194
  • Peer Reviewed / Open Access
• [Journal Article] Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3 : a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology. (2021)
  • Author(s): Ikeda M, Mikami M, Yasaka M, Enomoto T, Kobayashi Y, Nagase S, Yokoyama M, Katabuchi H.
  • Journal Title: J Gynecol Oncol Volume: 32 Issue: 5 Pages: e68
  • DOI: 10.3802/jgo.2021.32.e68
  • Peer Reviewed / Open Access
• [Journal Article] Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population : baseline data from the Japan Multi-Institutional Collaborative Cohort Study (2021)
  • Author(s): Sakurako Katsuura-Kamano, Kokichi Arisawa, Hirokazu Uemura, Nguyen Van Tien, Takezaki Toshiro, Takeuchi Kenji, Wakai Kenji
  • Journal Title: Preventive Medicine Reports Volume: 24 Pages: 101613
  • DOI: 10.1016/j.pmedr.2021.101613
  • Peer Reviewed / Open Access
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• [Journal Article] Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer. (2021)
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• [Journal Article] Clinical Significance of TAP1 and DLL4 Expression in Patients With Locally Advanced Gastric Cancer. (2021)
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• [Journal Article] Enhanced MR Conspicuity of Type IIb Focal Cortical Dysplasia by T1WI With CHESS : Two Case Reports. (2021)
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• [Journal Article] Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer's disease (2021)
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• [Journal Article] Parkinson's disease with a typical clinical course of 17 years overlapped by Creutzfeldt-Jakob disease : an autopsy case report (2021)
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• [Journal Article] Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants. (2021)
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  • Journal Title: Commun Biol. Volume: 4 Pages: 961
  • DOI: 10.1038/s42003-021-02475-6
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of 11-year incidence of psychophysically dependent status or death among community-dwelling younger elderlies : from an age-specified community-based cohort study (the NISSIN project). (2021)
  • Author(s): Okabayashi S, Kawamura T, Noma H, Wakai K, Ando M, Tsushita K, Ohira H, Ukawa S, Tamakoshi A
  • Journal Title: Environ Health Prev Med Volume: 26 Issue: 1 Pages: 45
  • DOI: 10.1186/s12199-021-00968-8
  • Peer Reviewed / Open Access
• [Journal Article] Presence of Microplastics in Four Types of Shellfish Purchased at Fish Markets in Okayama City, Japan. (2021)
  • Author(s): Yamamoto K, Oshiki T, Kagawa H, Namba M, Sakaguchi M.
  • Journal Title: Acta Med Okayama Volume: 75 Pages: 381-384
  • DOI: 10.18926/AMO/62234
  • Peer Reviewed
• [Journal Article] Regional neuromuscular regulation within rectus femoris muscle following three-month limb-loaded walking in older adults (2021)
  • Author(s): Narouei S, Akatsu H, Watanabe K
  • Journal Title: Sports Medicine and Health Science
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between fasting blood glucose levels in middle age and cognitive function in later life : The Aichi Workers' Cohort Study. (2021)
  • Author(s): Shimoda M, Kaneko K, Nakagawa T, Kawano N, Otsuka R, Ota A, Naito H, Matsunaga M, Ichino N, Yamada H, Chiang C, Hirakawa Y, Tamakoshi K, Aoyama A, Yatsuya H.
  • Journal Title: J Epidemiol
  • DOI: 10.2188/jea.JE20210128
  • Peer Reviewed / Open Access
• [Journal Article] Relationship of hemoglobin level and plasma coproporphyrin-I concentrations as an endogenous probe for phenotyping OATP1B. (2021)
  • Author(s): Suzuki Y, Sasamoto Y, Koyama T, Yoshijima C, Oda A, Nakatochi M, Kubo M, Momozawa Y, Uehara R, Ohno K.
  • Journal Title: Clin Transl Sci Volume: 14 Pages: 1403-1411
  • DOI: 10.1111/cts.12996
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for early in-hospital death in patients who developed coagulopathy during induction therapy for acute promyelocytic leukemia : a nationwide analysis in Japan. (2021)
  • Author(s): Matsuda K, Jo T, Toyama K, Nakazaki K, Matsui H, Fushimi K, Yasunaga H, Kurokawa M.
  • Journal Title: Annals of Hematology Volume: 100 Issue: 10 Pages: 2613-2619
  • DOI: 10.1007/s00277-021-04620-x
  • Peer Reviewed
• [Journal Article] Risk Prediction for Gastric Cancer Using GWAS-Identifie Polymorphisms, Helicobacter pylori Infection and Lifestyle-Related Risk Factors in a Japanese Population (2021)
  • Author(s): Ishikura N, Ito H, Oze I, Koyanagi YN, Kasugai Y, Taniyama Y, Kawakatsu Y, Tanaka T, Ito S, Tajika M, Shimizu Y, Niwa Y, Matsuo K.
  • Journal Title: Cancers Volume: 13 Pages: 5525
  • DOI: 10.3390/cancers13215525
  • Peer Reviewed / Open Access
• [Journal Article] RUNX2 phosphorylation by tyrosine kinase ABL promotes breast cancer invasion. (2021)
  • Author(s): He F, Matsumoto Y, Asano Y, Yamamura Y, Katsuyama T, Rose J-L, Tomonobu N, Komalasari NLGY, Sakaguchi M, Rottapel R, Wada J.
  • Journal Title: Front Oncol. Volume: 11 Pages: 665273
  • DOI: 10.3389/fonc.2021.665273
  • Peer Reviewed / Open Access
• [Journal Article] Sedentary time, physical activity, and serum SPARC in a middle-aged population (2021)
  • Author(s): Nishida Y, Hara M, Higaki Y, Taguchi N, Nakamura K, Nanri H, Imaizumi T, Sakamoto T, Shimanoe C, Horita M, Shinchi K, Tanaka K
  • Journal Title: European Journal of Sport Science
  • DOI: 10.1080/17461391.2021.1974573
  • Peer Reviewed
• [Journal Article] Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy. (2021)
  • Author(s): Lövestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW.
  • Journal Title: FEBS Open Bio Volume: 11 Pages: 999-1013
  • DOI: 10.1002/2211-5463.13110
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum Laminin γ2 Monomer as a Diagnostic and Predictive Biomarker for Hepatocellular Carcinoma (2021)
  • Author(s): Yamashita T, Koshikawa N, et al.
  • Journal Title: Hepatology Volume: 74 Issue: 2 Pages: 760-775
  • DOI: 10.1002/hep.31758
  • Peer Reviewed
• [Journal Article] Sex-specific Relationship between Stress Coping Strategies and All-Cause Mortality : Japan Multi-Institutional Collaborative Cohort Study. (2021)
  • Author(s): Nagayoshi M, Takeuchi K, Tamada Y, Yasufumi K, Kubo Y, Okada R, Tamura T, ..., Kuriki K, ...
  • Journal Title: J Epidemiol.
  • DOI: 10.2188/jea.JE20210220
  • Peer Reviewed / Open Access
• [Journal Article] Structure-based classification of tauopathies (2021)
  • Author(s): Shi Y, Zhang W, Yang Y, Murzin A, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer H, Vidal R, Hallinan G, Lashley T, Saito Y, et al
  • Journal Title: Nature Volume: 598 Pages: 359-363
  • DOI: 10.1038/s41586-021-03911-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structures of TDP-43 filaments from amyotrophic lateral sclerosis with frontotemporal lobar degeneration (2021)
  • Author(s): Arseni D, Hasegawa M, Murzin AG, Kametani F, Arai M, Yoshida M, Falcon B
  • Journal Title: Nature
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12 (2021)
  • Author(s): Toyoda Y, Kawamura Y, Nakayama A, Nakaoka H, .., Morimoto K, Uchida N, Shigesawa R, Takeuchi K, Inoue I, Ichida K, Suzuki H, Shinomiya N, Takada T, Matsuo H.
  • Journal Title: Rheumatology Volume: 60 Pages: 5224-5232
  • DOI: 10.1093/rheumatology/keab327
  • Peer Reviewed / Open Access
• [Journal Article] Surveillance of radical hysterectomy for early-stage cervical cancer in the early experienced period of minimally invasive surgery in Japan. (2021)
  • Author(s): Ohta T, Nagase S, Okui Y, Enomoto T, Yamagami W, Mikami M, Tokunaga H, Ino K, Ushijima K, Shozu M, Tashiro H, Mandai M, Miyamoto S, et al.
  • Journal Title: Int J Clin Oncol Volume: 26 Issue: 12 Pages: 2318-2330
  • DOI: 10.1007/s10147-021-02017-4
  • Peer Reviewed / Open Access
• [Journal Article] The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. (2021)
  • Author(s): Tokunaga H, Mikami M, Nagase S, Kobayashi Y, Tabata T, Kaneuchi M, Satoh T, Hirashima Y, Matsumura N, Yokoyama Y, Kawana K, Kyo S, Aoki D, Katabuchi H
  • Journal Title: J Gynecol Oncol Volume: 32 Issue: 2 Pages: e49
  • DOI: 10.3802/jgo.2021.32.e49
  • Peer Reviewed / Open Access
• [Journal Article] The apparent inverse association between dietary carotene intake and risk of cardiovascular mortality disappeared after adjustment for other cardioprotective dietary intakes : The Japan Collaborative Cohort Study (2021)
  • Author(s): Gao Q, Eshak ES, Muraki I, Shirai K, Yamagishi K, Tamakoshi A, Iso H
  • Journal Title: Nutr Metab Cardiovasc Dis
  • DOI: 10.1016/j.numecd.2021.07.026
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Role of Hypertension and Renin-angiotensin-aldosterone System Inhibitors in Bleomycin-induced Lung Injury. (2021)
  • Author(s): Hara R, Onizuka M, Shiraiwa S, Harada K, Aoyama Y, Ogiya D, Toyosaki M, Suzuki R, Machida S, Ohmachi K, Ogawa Y, Kawada H, Watanabe S, Mikami M, et al.
  • Journal Title: Clin Lymphoma Myeloma Leuk Volume: 21 Issue: 4 Pages: 321-327
  • DOI: 10.1016/j.clml.2020.10.004
  • Peer Reviewed / Open Access
• [Journal Article] The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan : a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee. (2021)
  • Author(s): Ikeda M, Shida M, Shigeta S, Nagase S, Takahashi F, Yamagami W, Katabuchi H, Yaegashi N, Aoki D, Mikami M.
  • Journal Title: J Gynecol Oncol Volume: 32 Issue: 3 Pages: e44
  • DOI: 10.3802/jgo.2021.32.e44
  • Peer Reviewed / Open Access
• [Journal Article] The validity of the subsequent pregnancy index score for fertility-sparing trachelectomy in early-stage cervical cancer. (2021)
  • Author(s): Iwata T, Machida H, Matsuo K, Okugawa K, Saito T, Tanaka K, Morishige K, Kobayashi H, Yoshino K, Tokunaga H, Ikeda T, Shozu M, Yaegashi N, Enomoto T, Mikami M.
  • Journal Title: Fertil Steril Volume: 115 Issue: 5 Pages: 1250-1258
  • DOI: 10.1016/j.fertnstert.2020.09.162
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tissue factor and its procoagulant activity on cancer-associated thromboembolism in pancreatic cancer (2021)
  • Author(s): Satoshi Kobayashi, Shiro Koizume, Tomoko Takahashi, Makoto Ueno, ..., Sho Nakamura, Hiroto Narimatsu, Wolfram Ruf, Yohei Miyagi
  • Journal Title: Cancer Science Volume: 112 Pages: 4679-4691
  • DOI: 10.1111/cas.15106
  • Peer Reviewed / Open Access
• [Journal Article] Tocilizumab in VEXAS relapsing polychondritis : a single-center pilot study in Japan (2021)
  • Author(s): Kirino Y, Takase-Minegishi K, Tsuchida N, Hirahara L, Kunishita Y, Yoshimi R, Nakajima H.
  • Journal Title: Ann Rheum Dis
  • DOI: 10.1136/annrheumdis-2021-220876
  • Peer Reviewed
• [Journal Article] Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain (2021)
  • Author(s): 1. Watanabe N, Nakano M, Mitsuishi Y, Hara N, Mano T, Iwata A, Murayama S, Suzuki T, Ikeuchi T, Nishimura M.
  • Journal Title: Hum Mol Genet
  • DOI: 10.1093/hmg/ddab226
  • Peer Reviewed
• [Journal Article] Transcriptomic changes in hot spring frog tadpoles (Buergeria otai) in response to heat stress (2021)
  • Author(s): Komaki S, Matsunami M, Lin J-W, Lee K-H, Lee Y, Lin S-M, Igawa T
  • Journal Title: Frontiers in Ecology and Evolution
  • DOI: 10.3389/fevo.2021.706887
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer's Disease. (2021)
  • Author(s): Hoshi K, ...H, Ogawa N, Akatsu H, Hashizume Y, Tateno H, Honda T, Hashimoto Y.
  • Journal Title: Metabolites. Volume: Sep 10 ; 11 Issue: 9 Pages: 616
  • DOI: 10.3390/metabo11090616
  • Peer Reviewed / Open Access
• [Journal Article] Ultra-early cancer diagnosis and label-free circulating tumor cell detection by comprehensive analysis of blood and urine using spectroscopy (2021)
  • Author(s): HIROAKI ITO
  • Journal Title: Impact Volume: 2021 Issue: 6 Pages: 6-8
  • DOI: 10.21820/23987073.2021.6.6
  • Open Access
• [Journal Article] Urinary and plasma proteomics to discover biomarkers for diagnosing between diabetic nephropathy and minimal change nephrotic syndrome or membranous nephropathy (2021)
  • Author(s): Araumi A, Osaki T, Ichikawa K, Kudo K, Suzuki N, Watanabe S, Watanabe M, Konta T.
  • Journal Title: Biochem Biophys Rep Volume: 27 Pages: 101102
  • DOI: 10.1016/j.bbrep.2021.101102
  • Peer Reviewed / Open Access
• [Journal Article] Wait-time for adjuvant radiotherapy and oncologic outcome in early-stage cervical cancer : A treatment implication during the coronavirus pandemic. (2021)
  • Author(s): Matsuo K, Shimada M, Matsuzaki S, Enomoto T, Mikami M.
  • Journal Title: Eur J Cancer Volume: 148 Pages: 117-120
  • DOI: 10.1016/j.ejca.2021.02.013
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Work and Family Conflicts, Depression, and ″Ikigai″ : A Mediation Analysis in a Cross-Cultural Study Between Japanese and Egyptian Civil Workers (2021)
  • Author(s): Eshak ES, Baba S, Yatsuya H, Iso H, Hirakawa Y, Mahfouz EM, Chifa C, Sakaniwa R, E1-Khateeb AS.
  • Journal Title: J Epidemiol
  • DOI: 10.2188/jea.JE20210338
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 亜急性の認知機能低下と尿閉で発症した 中枢神経原発移植後リンパ増殖性疾患の1例 (2021)
  • Author(s): 横山尚佑, 神林隆道, 小林俊輔, 石田毅, 園生 雅弘.
  • Journal Title: 臨床神経学 Volume: 61 Pages: 750-755
  • DOI: 10.5692/clinicalneurol.cn-001623
  • Peer Reviewed
• [Journal Article] 総合診療医が担う脂質異常症診療 (2021)
  • Author(s): 池崎裕昭、Schaefer EJ、林 純
  • Journal Title: 日本病院総合診療医学会雑誌 Volume: 17 Pages: 326-334
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 慢性腎臓病による死亡の危険因子の検討 : JACC研究(総説) (2021)
  • Author(s): 郭帥, 山海知子, 山岸良匡, 木原朋未, 磯博康, 玉腰暁子
  • Journal Title: 日本循環器病予防学会誌 Volume: 57 Pages: 55-57
  • Peer Reviewed
• [Presentation] Phenotypic variation and therapeutic strategy of SCA8-associated amyotrophic lateral sclerosis (2022)
  • Author(s): Makito Hirano, Shigeo Murayama, Yuishin Izumi, Tomoyasu Matsubara, Yuko Saito, Kazumasa Saigoh, Yusaku Nakamura, Susumu Kusunoki, Yoshitaka Nagai
  • Organizer: 第63回日本神経学会総会
• [Presentation] PETを用いたアルツハイマー病のミトコンドリア障害と神経変性との病態関連研究 (2022)
  • Author(s): 寺田達弘、横倉正倫、武内智康、松平敬史、小尾智一、塚田秀夫、尾内康臣
  • Organizer: 第24回 日本ヒト脳機能機能マッピング学会
• [Presentation] 一般住民を対象とした血清カロテノイド値とAHRR遺伝子のDNAメチル化率との関連 -Yakumo Study- (2022)
  • Author(s): 坪井 良樹, 山田 宏哉, 宗綱 栄二, 藤井 亮輔, 山崎 未来, 安藤 嘉崇, 水野 元貴, 服部 裕次, 石原 裕也, 大橋 鉱二, 石川 浩章, 橋本 修二, 浜島 信之, 鈴木 康司
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 喫煙と慢性閉塞性肺疾患リスクとの関連 : J-MICC Study静岡・桜ヶ丘地区 (2022)
  • Author(s): 中野美鈴, 田中浩子, 栗木清典
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 血清中脂肪酸と白血球中ABCA1遺伝子メチル化率との関連 -Yakumo study- (2022)
  • Author(s): 石原 裕也, 山田 宏哉, 宗綱 栄二, 藤井 亮輔, 坪井 良樹, 山崎 未来, 安藤 嘉崇, 水野 元貴, 服部 裕次, 大橋 鉱二, 石川 浩章, 橋本 修二, 浜島 信之, 鈴木 康司
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 口腔健康度と肥満との関連 : J-MICC Study静岡・桜ヶ丘地区における横断研究 (2022)
  • Author(s): 田中浩子, 中野美鈴, 栗木清典
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 住民健診受診者における白血球中TXNIP遺伝子のDNAメチル化率と頸部動脈硬化指標との関連 (2022)
  • Author(s): 前田 圭介, 山田 宏哉, 宗綱 栄二, 藤井 亮輔, 坪井 良樹, 石原 裕也, 山崎 未来, 安藤 嘉崇, 水野 元貴, 石川 浩章, 大橋 鉱二, 刑部 恵介, 杉本 恵子, 市野 直浩, 橋本 修二, 浜島 信之, 鈴木 康司
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 早期パーキンソン病におけるゾニサミドの神経保護効果の評価 : PETによる3年間の追跡検討 (2022)
  • Author(s): 寺田達弘、横倉正倫、武内智康、松平敬史、高嶋浩嗣、小西高志、小尾智一、尾内康臣
  • Organizer: 第24回 日本ヒト脳機能機能マッピング学会
• [Presentation] 中高年者における喫煙と白血球SOCS3遺伝子のDNAメチル化率の関連 : Yakumo Study (2022)
  • Author(s): 鈴木 康司, 山田 宏哉, 宗綱 栄二, 藤井 亮輔, 山崎 未来, 安藤 嘉崇, 水野 元貴, 坪井 良樹, 服部 裕次, 石原 裕也, 大橋 鉱二, 石川 浩章, 橋本 修二, 浜島 信之
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 17β-estradiolによるHTLV-1感染制御の可能性 : Aromatase (Cyp19) -KOマウスを加齢モデルとして用いた解析 (2021)
  • Author(s): 相良康子、相良康弘、入田和男
  • Organizer: 令和3年度日本生化学会 九州支部例会
• [Presentation] A long non-coding RNA associated with chronic gastritis and gastric cancer promotes stress granule formation and inhibits apoptosis (2021)
  • Author(s): Hiroshi Kitajima, Reo Maruyama, Akira Takasawa, Takeshi Niinuma, Eiichiro Yamamoto, Kazuya Ishiguro, Masahiro Kai, Takashi Tokino, Hiroshi Nakase, Hiromu Suzuki
  • Organizer: The 39th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] AHRR遺伝子のDNAメチル化率と死亡リスクとの関連を調査した縦断研究 -Yakumo study- (2021)
  • Author(s): 坪井良樹、山田宏哉、藤井亮輔、石原裕也、橋本修二、浜島信之、鈴木康司
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] ALCAM(CD166)は大腸がん幹細胞の幹細胞性と転移能に寄与する (2021)
  • Author(s): 青木正博、武藤誠、藤下晃章
  • Organizer: 第25回日本がん分子標的治療学会
• [Presentation] Association between dietary fatty acid intake, serum levels of fatty acids and ABCA1 DNA methylation (2021)
  • Author(s): Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Yoshitaka Ando, Keisuke Maeda, Yoshiki Tsuboi, Kenji Wakai, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki, et al.
  • Organizer: World Congress of Epidemiology
  • Int'l Joint Research
• [Presentation] Association of drinking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population (2021)
  • Author(s): Keisuke Maeda, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Koji Ohashi, Yoshiki Tsuboi, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki
  • Organizer: World Congress of Epidemiology 2021
  • Int'l Joint Research
• [Presentation] Association of insulin-like growth factor (IGF) related molecules and incidence of colorectal cancer by site and gender (2021)
  • Author(s): 足立 靖、野島正寛、森 満、檜森亮吾、久保俊之、山野泰穂、仲瀬裕志、遠藤高夫、林 櫻松、若井建志、玉腰暁子
  • Organizer: 日本癌学会
• [Presentation] ATLにおけるCD30発現とその意義 (2021)
  • Author(s): 中島誠
  • Organizer: 第7回日本HTLV-1学会学術集会
  • Invited
• [Presentation] Baseline Global DNA Hypermethylation Increase the Risk of Cerebrovascular Disease Mortality in Japanese Population (2021)
  • Author(s): Yoshiki Tsuboi, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki, et al.
  • Organizer: World Congress of Epidemiology 2021
  • Int'l Joint Research
• [Presentation] Big data-driven research of neurodegenerative diseases (2021)
  • Author(s): Hitoshi Okazawa
  • Organizer: 62nd Annual Meeting of the Japanese Society of Neurology, ICCKyoto
  • Invited
• [Presentation] Characterization of OASEP1 as a potential prognostic biomarker and therapeutic target for oral cancer (2021)
  • Author(s): 高野 淳, 吉武 義弘, 篠原 正則, 醍醐 弥太郎
  • Organizer: 第19回日本臨床腫瘍学会
  • Int'l Joint Research
• [Presentation] Characterization of URST1 and its downstream pathways involved in malignant potential of lung cancer (2021)
  • Author(s): Atsushi Takano, Yohei Miyagi, Yataro Daigo
  • Organizer: 第80回日本癌学会
• [Presentation] Characterization of URST1 as a new prognostic biomarker and therapeutic target for oral cancer (2021)
  • Author(s): Atsushi Takano, Yoshihiro Yoshitake, Masanori Shinohara, Yataro Daigo,
  • Organizer: 第65回 日本人類遺伝学会
• [Presentation] Circulating microRNA and the development of hypertension : A five-year longitudinal population-based study (2021)
  • Author(s): Koji Suzuki, Hiroya Yamada, Ryosuke Fujii, Eiji Munetsuna, Yoshitaka Ando, Keisuke Maeda, Yoshiki Tsuboi, Shuji Hashimoto, Nobuyuki Hamajima, et al.
  • Organizer: World Congress of Epidemiology 2021
  • Int'l Joint Research
• [Presentation] Complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease : PET study (2021)
  • Author(s): Tatsuhiro T, Joseph T, Min Su K, Takashi M, Tomoyasu B, Tomokazu O, Hirotsugu T, Norihiko K, Yasukiyo A, Hideo T, Pedro RN, Yasuomi O
  • Organizer: 第62回日本神経学会学術大会
• [Presentation] Distinct phosphorylation profiles of tau in brains of patients with different tauopathies (2021)
  • Author(s): Nastaran Samimi, Taeko Kimura, Tomoyasu Matsubara, Yuko Saito, Shigeo Murayama, Masato Hasegawa, Kanae Ando, Shin-ichi Hisanaga
  • Organizer: 第64回日本神経化学会
• [Presentation] DLEU1はインターフェロン関連遺伝子の発現とヒストン修飾を制御し口腔扁平上皮癌の進行を促進する (2021)
  • Author(s): 畠中柚衣、新沼猛、西山廣陽、北嶋洋志、山本英一郎、甲斐正広、萬顕、関口翔平、荻和弘、宮﨑晃亘、鈴木拓
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] DOT1L阻害は乳がん細胞のトランスクリプトームおよびエピゲノムシグネチャーを変化させる (2021)
  • Author(s): 鈴木拓、丸山玲緒、北嶋洋志、新沼猛、石黒一也、粂川昴平、吉戸文乃、佐々木基、山本英一郎、甲斐正広、仲瀬裕志
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Early detection of colorectal cancers by miRNA expression analysis of cohort samples (2021)
  • Author(s): 菱田朝陽、山田宏哉、奥川喜永、塩澤学、宮城洋平、醍醐弥太郎、問山裕二、田中光司
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] EphA2およびEGFRを介した肝細胞がん進展の数理モデリング (2021)
  • Author(s): 中村直俊、室井敦、朝倉暢彦、野島陽水、榎本将士、鈴木貴、越川直彦
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Estimated prevalence of metabolic syndrome components by simulated reducing amount and frequency of alcohol intake (2021)
  • Author(s): Ippei Shimoshikiryo, Rie Ibusuki, Keiichi Shimatani, Daisaku Nishimoto, Toshiro Takezaki, For The Japan Multi-Institutional Collaborative Cohort Study Group
  • Organizer: INTERNATIONAL EPIDEMIOLOGICAL ASSOCIATION'S WORLD CONGRESS OF EPIDEMIOLOGY 2021
  • Int'l Joint Research
• [Presentation] FACTORS THAT INFLUENCE THE PREFERENCE FOR HOME AS THE LOCATION FOR LONG-TERM CARE IN THE JAPANESE POPULATION (2021)
  • Author(s): Ukawa S, Kato Y, Yonggeun L, Ohara K and Mori K
  • Organizer: The 7th International Conference on Public Health 2021
  • Int'l Joint Research
• [Presentation] Gene and environmental factors for liver fibrosis among Japanese general population with NAFLD (2021)
  • Author(s): Rie Ibusuki, Ippei Shimoshikryo, Daisaku Nishimoto, Hironori Miyahara, Koichi Tokushige, Toshiro Takezaki
  • Organizer: INTERNATIONAL EPIDEMIOLOGICAL ASSOCIATION'S WORLD CONGRESS OF EPIDEMIOLOGY 2021
  • Int'l Joint Research
• [Presentation] Glucose取り込み低下を伴う脳毛細血管障害は新たな精神疾患の指標となりうるか (2021)
  • Author(s): 平井 志伸, 三輪 秀樹, 國井 泰人, 新井 誠, 岡戸 晴生
  • Organizer: 第51回日神経精神薬理学会
• [Presentation] Helicobacter pylori infection in parents and their children (2021)
  • Author(s): Miki Watanabe, Teruo Nagaya, Hiroko Nakagawa-Senda, Satoyo Hosono, Kyoko Ban, Tamaki Yamada, Sadao Suzuki
  • Organizer: 22th IEA World Congress of Epidemiology
  • Int'l Joint Research
• [Presentation] HIF1A-dependent autophagy mitigates alpha-synuclein pathology and cognitive impairment (2021)
  • Author(s): Tatsuo Mano, Gaku Ohtomo, Atsushi Iwata, Tatsushi Toda
  • Organizer: 第62回日本神経学会
• [Presentation] HIF1α依存性オートファジーによるαシヌクレイン病理の分解促進 (2021)
  • Author(s): 大友 岳, 間野 達雄, 岩田 淳, 戸田 達史
  • Organizer: 第40回 日本認知症学会
• [Presentation] HMGB1モノクローナル抗体による前頭側頭葉変性症の治療開発 (2021)
  • Author(s): 岡澤 均
  • Organizer: 第36回日本老年精神医学会
  • Invited
• [Presentation] HTLV-1感染診断の正確性向上のための新規推奨検査アルゴリズムの確立と診断指針の改定 (2021)
  • Author(s): 大隈 和、倉光 球、相良 康子、中村 仁美、蕎麦田 理英子、佐竹 正博、梅木 一美、岡山 昭彦、佐藤 知雄、山野 嘉久、板橋 家頭夫、齋藤 滋、渡邉 俊樹、浜口 功
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] Identification of a long non-coding RNA associated with gastritis and gastric cancer (2021)
  • Author(s): Hiroshi Kitajima, Reo Maruyama, Takeshi Niinuma, Akira Takasawa, Eiichiro Yamamoto, Kazuya Ishiguro, Masahiro Kai, Hiroshi Nakase, Takashi Tokino, Hiromu Suzuki
  • Organizer: 第22回日本RNA学会年会
  • Int'l Joint Research
• [Presentation] Identification of URST1 as a cancer biomarker and therapeutic target for lung cancer (2021)
  • Author(s): Atsushi Takano, Yohei Miyagi, Yataro Daigo,
  • Organizer: 2021 AACR meeting
  • Int'l Joint Research
• [Presentation] Identification of URST1 as a prognostic biomarker and therapeutic target for lung cancer (2021)
  • Author(s): Atsushi Takano, Yohei Miyagi, Yataro Daigo.
  • Organizer: AACR 2021
  • Int'l Joint Research
• [Presentation] Insulin-like growth factor (IGF)-2 and incidence of colorectal cancer, differences by site and gender (2021)
  • Author(s): 足立 靖、野島正寛、森 満、久保俊久、檜森亮吾、山野泰穂、仲瀬裕志、林 櫻松、若井建志、遠藤高夫、玉腰暁子
  • Organizer: 日本消化器癌発生学会
• [Presentation] Long noncoding RNA TUG1 regulates R-loop resolution and maintains cancer cell proliferation (2021)
  • Author(s): Miho Suzuki, Kenta Iijima, Keiko Shinjo, and Yutaka Kondo
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] MR-proADMの血管不全に対するバイオマーカーとしての検討 (2021)
  • Author(s): 小山晃英
  • Organizer: 第50回日本心脈管作動物質学会
• [Presentation] NAFLD肝線維化に対する環境・宿主要因の相互作用に関する研究 (2021)
  • Author(s): 指宿りえ、下敷領一平、西本大策、宮原宏典、徳重浩一、嶽崎俊郎
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] Participation in social group activities and risk of dementia : a systematic review (2021)
  • Author(s): Taniguchi R, Ukawa S
  • Organizer: The 7th International Conference on Public Health 2021
  • Int'l Joint Research
• [Presentation] Proposal of more practical diagnosis of renal hypouricemia : revealed by genetic studies of nonfunctional variants of URAT1/SLC22A12 among 30,685 Japanese individuals (2021)
  • Author(s): Kawamura Y, Nakayama A, Nakashima H, Tsunoda M, Wakai K, Shinomiya N, Matsuo H, et al.
  • Organizer: G-CAN 7th Annual Research Symposium
  • Int'l Joint Research
• [Presentation] Protective effect of common and rare variants of URAT1/SLC22A12 on gout (2021)
  • Author(s): Toyoda Y, Kawamura Y, Nakayama A, Nakaoka H, .., Morimoto K, Uchida N, Shigesawa R, Takeuchi K, Inoue I, Ichida K, Suzuki H, Shinomiya N, Takada T, Matsuo H.
  • Organizer: The 19th Symposium (PP21) on Purine and Pyrimidine Metabolism in Man
  • Int'l Joint Research
• [Presentation] Relationship between dietary vitamin D intake, obesity, and twenty lipoprotein subclasses : results from the Kyushu and Okinawa Population Study (KOPS) (2021)
  • Author(s): Ikezaki H, Nakashima R, Ai M, Okazaki M, Kohzuma T, Schaefer EJ
  • Organizer: 89th EAS Congress
  • Int'l Joint Research
• [Presentation] Relationship between dietary vitamin D intake, obesity, and twenty lipoprotein subclasses : results from the Kyushu and Okinawa Population Study (KOPS) (2021)
  • Author(s): Ikezaki H, Nakashima R, Furusyo N, Ai M, Okazaki M, Hayashi J, Schaefer EJ
  • Organizer: AHA Scientific Sessions 2021
  • Int'l Joint Research
• [Presentation] Relationship Between the Cholesterol and Triglyceride Content of Lipoprotein Subclasses and Carotid Intima-Media Thickness : Results from the Kyushu and Okinawa Population Study (2021)
  • Author(s): Ikezaki H, Furusyo N, Ai M, Okazaki M, Hayashi J, Schaefer EJ
  • Organizer: AHA Scientific Sessions 2021
  • Int'l Joint Research
• [Presentation] Replacing sedentary time with moderate-to-vigorous physical activity is associated with decreased serum SPARC in men (2021)
  • Author(s): Yuichiro Nishida, Megumi Hara, Yasuki Higaki, Naoto Taguchi, Chisato Shimanoe, Mikako Horita, Koichi Shinchi, Keitaro Tanaka
  • Organizer: World Congress of Epidemiology 2021
  • Int'l Joint Research
• [Presentation] sCADM1はATLLの新規のバイオマーカー候補となる (2021)
  • Author(s): 中畑新吾、Chilmi Syahrul、中武彩子、吉浜麻生、松浦正、武本重毅、中野伸亮、斎藤益満、岩永正子、相良康子、前田宏一、宇都宮與、下田和哉、渡邊俊樹1、森下和広
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1 (2021)
  • Author(s): 鈴木拓
  • Organizer: 第39回札幌国際がんシンポジウム
  • Int'l Joint Research / Invited
• [Presentation] Spatiotemporal Regulation of Long non-coding RNA to propagate Cancer Cells (2021)
  • Author(s): Miho Suzuki, Yutaka Kondo
  • Organizer: 合同大会 第126回 日本解剖学会総会・全国学術集会 第98回 日本生理学会大会
  • Invited
• [Presentation] Substantial gout protective effect by common and rare variants of URAT1/SLC22A12 gene (2021)
  • Author(s): Toyoda Y, Kawamura Y, Nakayama A, Nakaoka H, Higashino T, ..., Takeuchi K, Inoue I, Ichida K, Suzuki H, Shinomiya N, Takada T, and Matsuo H
  • Organizer: 23th APLAR (Asia-Pacific League of Associations for Rheumatology) Congress in 2021
  • Int'l Joint Research
• [Presentation] Sykがタウ蛋白リン酸化、重合に及ぼす影響の検討 (2021)
  • Author(s): 山口 智久、定 清直、Nicholas M Kanan、村山 繁雄、佐々木 宏仁、Yen Shu-Hui、高久 直子、北崎 佑樹、榎本 崇一、白藤 法道、井川 正道、山村 修、濱野 忠則
  • Organizer: 第40回日本認知症学会
• [Presentation] Tau-induced Aggregation of BRCA1 in Tauopathies (2021)
  • Author(s): Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Atsushi Iwata, Tatsushi Toda
  • Organizer: 17th Asian Oceanian Congress of Neurology
  • Int'l Joint Research
• [Presentation] Toward establishment of a cohort ready for interventional clinical trials-Monitoring disease progression in patients with hereditary motor and sensory neuropathy with proximal dominant involvement (2021)
  • Author(s): Shugo Suwazono, Natsumi Fujisaki
  • Organizer: PACTALS in Nagoya 2021
  • Int'l Joint Research
• [Presentation] URAT1/SLC22A12遺伝子の機能低下型のcommon/rare variantによる強力な痛風発作抑制効果の同定 (2021)
  • Author(s): 堀江美音、豊田優、河村優輔、中山昌喜、中岡博史、東野俊英、清水聖子、藤原慎、田中里沙、大山博司、竹内研時、井ノ上逸郎、鈴木洋史、市田公美、四ノ宮成祥、高田龍平、松尾洋孝
  • Organizer: 第1回トランスポーター研究会関西部会
• [Presentation] URAT1/SLC22A12遺伝子の機能低下型のcommon/rare variantは痛風発作を強力に抑制する (2021)
  • Author(s): 鳥羽美帆、豊田優、河村優輔、中山昌喜、中岡博史、東野俊英、清水聖子、水田奈々子、田中里沙、大山博司、若井建志、井ノ上逸郎、鈴木洋史、市田公美、四ノ宮成祥、高田龍平、松尾洋孝
  • Organizer: 第12回トランスポーター研究会九州部会
• [Presentation] アルツハイマー病理の脳領域分布に着目した研究 (2021)
  • Author(s): 篠原 充
  • Organizer: 第6回 拡大ワークショップ 名古屋大学 脳とこころの研究センター
• [Presentation] アルファスクリーンを用いた血清中の抗HTLV-1抗体測定法の開発 (2021)
  • Author(s): 舩橋利佳子、鈴木智津、山岡悠太郎、宮川 敬、木村弥生、梁 明秀
  • Organizer: 第72回日本電気泳動学会総会
• [Presentation] エネルギー毒性 (2021)
  • Author(s): 石堂正美
  • Organizer: 第94回日本生化学会
  • Invited
• [Presentation] がんの転移制御を目指して (2021)
  • Author(s): 阪口政清
  • Organizer: 第12回岡山肺癌基礎研究会
  • Invited
• [Presentation] がん幹細胞マーカーによる肝細胞がんの分類とEphA2シグナル伝達 (2021)
  • Author(s): 朝倉暢彦、室井敦、中村直俊、野島陽水、越川直彦、鈴木貴
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] タンパク質蓄積病態に影響するファクターとは (2021)
  • Author(s): 里 直行
  • Organizer: 第40回日本認知症学会学術集会
  • Invited
• [Presentation] ビタミンD摂取量が脂質20分画と肥満に与える影響の検討-Kyushu and Okinawa Population Studyの結果より (2021)
  • Author(s): 池崎裕昭、中嶋綾子、古庄憲浩、藍 真澄、岡崎三代、林 純、Ernst J Schaefer
  • Organizer: 第53回日本動脈硬化学会総会・学術集会
• [Presentation] メンデルのランダム化法による血中脂質と大腸がんの開係の検討 (2021)
  • Author(s): 岩上将夫、後藤温、鈴木詩織、片桐諒子、羽入田明子、山地太樹、澤田典絵、中杤昌弘、若井建志、須藤洋一、清水厚志、丹野高三、木下賢吾、寶澤篤、伊藤秀美、松尾恵太郎、岩崎基
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] メンデルのランダム化法による糖代謝指標と大腸がんの関連解析 (2021)
  • Author(s): 羽入田明子、後藤温、鈴木詩織、片桐諒子、岩上将夫、山地太樹、澤田典絵、中杤昌弘、若井建志、須藤洋一、清水厚志、丹野高三、木下賢吾、寶澤篤、伊藤秀美、松尾恵太郎、岩崎基
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] ラミニンγ2単鎖が肝発がんに及ぼす新たな機能の解析 (2021)
  • Author(s): 舟橋伸昭、越川直彦
  • Organizer: 日本がん転移学会学術集会
• [Presentation] 胃炎胃がん関連lncRNAはストレス顆粒形成を促進し、アポトーシスを抑制する (2021)
  • Author(s): 北嶋洋志、丸山玲緒、髙澤啓、新沼猛、山本英一郎、石黒一也、吉戸文乃、甲斐正広、小山内誠、時野隆至、仲瀬裕志、鈴木拓
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 胃炎胃がん関連長鎖non-coding RNAはストレス顆粒形成を促進し、アポトーシスを抑制する (2021)
  • Author(s): 北嶋洋志、丸山玲緒、高澤 啓、新沼 猛、山本英一郎、石黒一也、吉戸文乃、甲斐正広、小山内誠、時野隆至、仲瀬裕志、鈴木 拓
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 胃炎胃がん関連長鎖non-coding RNAはストレス顆粒形成を促進し、アポトーシスを抑制する。 (2021)
  • Author(s): 北嶋洋志、丸山玲緒、高澤 啓, 新沼 猛、山本英一郎、石黒一也、吉戸文乃、甲斐正広、小山内誠、時野隆至、仲瀬裕志、鈴木 拓
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 一般住民を対象とした喫煙習慣とAHRR遺伝子のDNAメチル化率との関連 (2021)
  • Author(s): 坪井良樹、山田宏哉、宗綱栄二、藤井亮輔、安藤嘉崇、水野元貴、石原裕也、石川浩章、大橋鉱二、橋本修二、鈴木康司
  • Organizer: 第53回藤田医科大学医学会学術大会
• [Presentation] 沖縄型神経原性筋萎縮症(HMSN-P)6症例における複数回のHAL[○!R]治療効果の検討 (2021)
  • Author(s): 城戸美和子, 谷川健祐, 妹尾洋, 藤原善寿, 藤﨑なつみ, 中地亮, 渡嘉敷崇, 諏訪園秀吾
  • Organizer: 第62回日本神経学会学術大会
• [Presentation] 沖縄型神経原性筋萎縮症(HMSN-P)患者の呼吸機能の経過について (2021)
  • Author(s): 藤崎なつみ, 諏訪園秀吾, 末原雅人, 中地亮, 城戸美和子, 藤原善寿, 妹尾洋, 渡嘉敷崇, 髙嶋博
  • Organizer: 第62回日本神経学会学術大会
• [Presentation] 沖縄型神経原性筋萎縮症7例におけるHAL医療用下肢タイプの繰り返し使用効果の検討 (2021)
  • Author(s): 諏訪園秀吾・城戸美和子・藤﨑なつみ・藤原善寿
  • Organizer: 第10回日本脳神経HAL研究会
• [Presentation] 加齢に伴う造血の変化 -造血幹細胞エイジングに着目して- (2021)
  • Author(s): 田所優子
  • Organizer: 第43回 日本生物学的精神医学会・第51回 日本神経精神薬理学会 合同年会 BPNP2021 サテライトシンポジウム
• [Presentation] 過敏性腸症候群と食習慣及び食品摂取頻度の関連 (2021)
  • Author(s): 和田瑞穂、尾﨑悦子、渡邊能行
  • Organizer: 第68回日本栄養改善学会学術総会
• [Presentation] 肝逸脱酵素に対する身体活動とコーヒー飲用および飲酒の交互作用 (2021)
  • Author(s): 西田裕一郎、原めぐみ、桧垣靖樹、田口尚人、中村和代、南里妃名子、今泉猛、坂本龍彦、島ノ江千里、堀田美加子、新地浩一、田中恵太郎、J-MICC Study Group
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 肝発がんにおけるLn-γ2mの機能解析 (2021)
  • Author(s): 舟橋伸昭、岡田光、山下太郎、金子周一、清木元治、越川直彦
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 血清カロテノイド値と白血球SOCS3 DNAメチル化率との関連-Yakumo Study- (2021)
  • Author(s): 鈴木康司、山田宏哉、藤井亮輔、坪井良樹、前田圭介、石原裕也、橋本修二、浜島信之
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 血糖値に対する緑茶・カテキン摂取量と腸内細菌叢の関連についての横断的検討 (2021)
  • Author(s): 伊東 葵、古郡かすみ、橘 拓希、川島晃子、川畑春佳、後藤千穂、栗木清典
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 血糖調節指標に対する血糖値の調節に関わる遺伝的要因と栄養素摂取量の横断的検討 (2021)
  • Author(s): 橘 拓希、川島晃子、川畑春佳、伊東 葵、古郡かすみ、可児美月、後藤千穂、栗木清典
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 原因因子や危険因子に着目したアルツハイマー病の病態解明, 治療薬開発 (2021)
  • Author(s): 篠原 充
  • Organizer: 第63回日本老年医学会学術集会
  • Invited
• [Presentation] 口腔がんの新規予後マーカー、治療標的分子URST1の同定 (2021)
  • Author(s): 高野 淳、吉武 義弘、篠原 正憲、醍醐 弥太郎
  • Organizer: 人類遺伝学会第66回大会
• [Presentation] 甲状腺未分化癌細胞株に対するEZH2阻害薬の効果 (2021)
  • Author(s): 中山博貴、星野大輔、菅沼伸康、戸田宗治、益戸功彦、宮城洋平、岩崎博幸、利野靖
  • Organizer: 第54回日本内分泌外科学会学術大会
• [Presentation] 行動型前頭側頭型認知症様症状を呈した辺縁系優位レビー病理を伴うアルツハイマー病の一剖検例 (2021)
  • Author(s): 別宮 豪一、繁信 和恵、右近 琴、米延 友希、山下 里佳、池田 学、森井 英一、村山 繁雄、望月 秀樹.
  • Organizer: 第62回日本神経病理学会総会学術研究会
• [Presentation] 高深度プロテオーム解析による大腸癌早期診断血液バイオマーカーの同定 (2021)
  • Author(s): 森治樹、阿部雄一、磯村久徳、山田有沙、奥本泰秀、島田友香子、山田啓策、木下敬史、小森康司、清水泰博、丹羽康正、田近正洋、田口歩
  • Organizer: 2021年度コホート・生体試料支援プラットフォーム(CoBiA)若手支援研究成果発表会
• [Presentation] 死後脳を用いた統合失調症脳病態のストレス・炎症関連分子による層別化の試み (2021)
  • Author(s): 宍戸理紗, 國井泰人, 日野瑞城, 長岡敦子, 泉竜太, 矢部博興
  • Organizer: 第43回日本生物学的精神医学会
• [Presentation] 自然感染におけるHTLV-1検査のウインドウ・ピリオドの推測 (2021)
  • Author(s): 相良康子、中村仁美、山本 翠、高瀬隆義、入田和男
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] 住民健診受診者における生活習慣病の未診断率と未診断者の検査値の検討 (2021)
  • Author(s): 池崎裕昭、中嶋綾子、梅本真紀子、松本佑慈、太田 梓、山嵜 奨、平峯 智、髙山耕治、小川栄一、豊田一弘、村田昌之、林 純、下野信行
  • Organizer: 第23回日本病院総合診療医学会学術集会
• [Presentation] 循環器疾患既往者における脂肪酸摂取量と死亡との関連 : JACC Study (2021)
  • Author(s): Sun Wanlu, 山岸良匡, 木原朋未, 岸田里恵, 玉腰暁子, 磯博康
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] 初経年齢と循環器疾患死亡との関連 : JACC Study (2021)
  • Author(s): 太田加奈子, 山岸良匡, 岸田里恵, 木原朋未, 崔仁哲, 磯博康, 玉腰暁子
  • Organizer: 第57回日本循環器病予防学会学術総会
• [Presentation] 食餌に由来する神経障害性のあるシアル酸分子種の体内動態の分析 (2021)
  • Author(s): 勝又千裕、南彰、田口理紗、後藤純、金澤寛明、鈴木隆、竹内英之
  • Organizer: 第85回日本生化学会中部支部例会・シンポジウム
• [Presentation] 新たな肝細胞がんを予測する新たなバイオマーカーとしての血清ラミニンγ2モノマー (2021)
  • Author(s): 越川直彦、山下太郎、中川将利、吉田栄作、吉村徹、金子周一、清木元治
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 新規転移性大腸がんマウスモデルの作出と転移機構の解析 (2021)
  • Author(s): 青木正博
  • Organizer: 第30回日本がん転移学会学術集会・総会
• [Presentation] 新規頭頸部癌関連long non-coding RNAの同定と機能解析 (2021)
  • Author(s): 新沼猛、北嶋洋志、畠中柚衣、関口翔平、萬顕、久保俊之、佐々木基、原田拓、甲斐正広、仲瀬裕志、鈴木拓
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 生前診断が行動型前頭側頭型認知症で、病理学的にアルツハイマー病と診断した一例 (2021)
  • Author(s): 別宮 豪一、村山 繁雄、繁信 和恵、右近 琴、米延 友希、山下 里佳、池田 学、森井 英一、望月 秀樹.
  • Organizer: 第40回日本認知症学会学術集会
• [Presentation] 脊髄小脳失調症8型(SCA8)に進行性核上性麻痺(PSP)様非定型4R-tauopathyを合併した一例 (2021)
  • Author(s): 米延 友希、山下 里佳、別宮 豪一、村山 繁雄、望月 秀樹.
  • Organizer: 第62回日本神経病理学会総会学術研究会
• [Presentation] 全死亡に対するHTLV-Ⅰと炎症性サイトカイン遺伝子多型の交互作用に関する研究 (2021)
  • Author(s): 嶽﨑俊郎、指宿りえ、西本大策、下敷領一平
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 大規模コホート研究に参加した日本人の成人男女における生年別ピロリ菌感染率 (2021)
  • Author(s): 川合紗世、篠壁多恵、菱田朝陽、王超辰、林櫻松、菊地正悟
  • Organizer: 第27回日本ヘリコバクター学会学術集会
• [Presentation] 大腸腫瘍組織における翻訳後修飾変化の解析 (2021)
  • Author(s): 三城 恵美・藤下 晃章・小島 康・梶野 リエ・田中 努・田近 正洋・青木 正博
  • Organizer: 日本プロテオーム学会2021年大会(JHUPO第19回大会)
• [Presentation] 朝食欠食および睡眠時間とメタボリック症候群との関連 : J-MICC Study (2021)
  • Author(s): 釜野桜子、有澤孝吉、Nguyen Van Tien、上村浩一、for the J-MICC Study Group
  • Organizer: 第31回日本疫学会総会
• [Presentation] 低酸素誘導因子HIF1A依存的オートファジーはαシヌクレイン病理を改善させる (2021)
  • Author(s): 間野達雄, 大友岳, 岩田淳, 戸田達史
  • Organizer: 第44回日本神経科学大会
• [Presentation] 糖尿病による認知機能障害の機序_臨床データベースとモデル動物の解析から (2021)
  • Author(s): 里 直行
  • Organizer: 第63回日本老年医学会学術集会
  • Invited
• [Presentation] 統合失調症病態におけるプロリン代謝経路分子の解析-死後脳研究 (2021)
  • Author(s): 長岡敦子, 國井泰人, 日野瑞城, 泉竜太, 宍戸理紗, 齊ノ内信, 柿田明美, 矢部博興
  • Organizer: 第43回日本生物学的精神医学会
• [Presentation] 内臓脂肪面積に対する脂肪酸摂取量と赤血球膜脂肪酸構成割合、遺伝的要因の横断的検討 (2021)
  • Author(s): 川畑春佳、川島晃子、橘 拓希、伊東 葵、古郡かすみ、可児美月、後藤千穂、栗木清典
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 日本食品標準成分表2020年版(八訂)を用いた中高年地域集団の食事評価に関する検討 (2021)
  • Author(s): 今枝 奈保美、篠壁 多恵、後藤 千穂、細野 晃弘、内藤 真理子、宮川 尚子、尾崎 悦子、南里 妃名子、矢口 友理、中畑 典子、釜野 桜子、栗原 綾子、若井 建志
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 日本人を対象としたX染色体ワイドメタ解析による新規尿酸関連SNPの同定 (2021)
  • Author(s): 中杤昌弘, 豊田優, 金井仁弘, 中山昌喜, 河村優輔, 菱田朝陽, 三上春夫, 松尾恵太郎, 嶽崎俊郎, 桃沢幸秀, The Biobank Japan Project, 鎌谷洋一郎, 市原佐保子, 四ノ宮成祥, 横田充弘, 若井建志, 岡田随象, 松尾洋孝, Japan Urate
  • Organizer: 日本人類遺伝学会第66回大会
• [Presentation] 尿酸異常症の遺伝的背景とその病態の解明に向けた臨床遺伝学的研究 (2021)
  • Author(s): 中山昌喜
  • Organizer: 日本人類遺伝学会第66回大会
  • Invited
• [Presentation] 尿酸輸送体遺伝子URAT1/SLC22A12の機能消失型変異に対する日本人集団4,993名における低尿酸血症の遺伝解析 (2021)
  • Author(s): 中山昌喜、河村優輔、豊田優、清水聖子、川口真、堀江美音、青木優佳、竹内研時、岡田理恵子、久保陽子、今給黎敏彦、岩澤聡子、中島宏、角田正史、伊藤敬一、熊谷裕生、高田龍平、市田公美、四ノ宮成祥、松尾洋孝
  • Organizer: 日本人類遺伝学会第66回大会
• [Presentation] 尿酸輸送体遺伝子URAT1/SLC22A12の機能消失型変異の影響 : 日本人集団4,993名における低尿酸血症の遺伝子解析 (2021)
  • Author(s): 中山昌喜, 河村優輔, 豊田優, 清水聖子, 川口真, 鳥羽美帆, 田中里沙, 竹内研時, 岡田理恵子, 久保陽子, 今給黎敏彦, 岩澤聡子, 中島宏, 角田正史, 伊藤敬一, 熊谷裕生, 高田龍平, 市田公美, 四ノ宮成祥, 松尾洋孝
  • Organizer: 第39回日本ヒト細胞学会学術集会
• [Presentation] 妊娠期の母体栄養障害と仔の生後の行動異常-低栄養と過剰葉酸摂取との相互作用について- (2021)
  • Author(s): 宇田川潤、小野哲男、日野広大、木村智子、内村康寛、芦原貴司、比嘉貴子、小島秀人、村上節
  • Organizer: 第10回日本DOHaD学会
• [Presentation] 妊娠母体の環境と子の心の発達との関連について～基礎研究からの知見を中心に～ (2021)
  • Author(s): 宇田川潤
  • Organizer: 第9回新胎児学研究会
  • Invited
• [Presentation] 認知症発症リスク因子となるシアル酸分子種の脳内移行性の解析 (2021)
  • Author(s): 勝又千裕、南彰、紅林佑希、高橋忠伸、鈴木隆、竹内英之
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
• [Presentation] 脳希少糖を取り込んだ糖脂質が認知症に及ぼす影響の解析 (2021)
  • Author(s): 荻野加奈子、南彰、中尾初音、平林義雄、鈴木隆、竹内英之
  • Organizer: 第36回SAM学会学術大会
• [Presentation] 白血球SLC30A8遺伝子DNAメチル化率と糖代謝指標との関連-Yakumo study- (2021)
  • Author(s): 石原裕也、山田宏哉、藤井亮輔、坪井良樹、橋本修二、浜島信之、鈴木康司
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 肥満に対するアルコールの摂取量と代謝酵素遺伝子多型の関連、季節の関連 (2021)
  • Author(s): 古郡かすみ、可児美月、五十嵐麻希、後藤千穂、栗木清典
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 肥満に対する高たんぱく質食品摂取量と腸内細菌叢の関連 : 四季食事調査の横断的検討 (2021)
  • Author(s): 川島晃子、川畑春佳、橘 拓希、伊東 葵、古郡かすみ、可児美月、後藤千穂、栗木清典
  • Organizer: 第80回日本公衆衛生学会総会
• [Presentation] 慢性胃炎・胃がん関連長鎖non-coding RNAによるストレス顆粒形成の促進と発がん機構の解析 (2021)
  • Author(s): 北嶋洋志、丸山玲緒、新沼 猛、高澤 啓、山本英一郎、石黒一也、甲斐正広、吉戸文乃、小山内誠、時野隆至、仲瀬裕志、鈴木 拓
  • Organizer: 第123回北海道癌談話会
• [Presentation] 慢性胃炎・胃がん関連長鎖non-coding RNAはストレス顆粒形成を促進し、アポトーシスを抑制する (2021)
  • Author(s): 北嶋洋志、丸山玲緒、新沼 猛、山本英一郎、高澤 啓、石黒一也、甲斐正広、吉戸文乃、小山内誠、時野隆至、仲瀬裕志、鈴木 拓
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] 慢性腎臓病による死亡の危険因子の検討 : JACC Study (2021)
  • Author(s): 郭帥, 山海知子, 山岸良匡, 木原朋未, 磯博康, 玉腰暁子
  • Organizer: 第57回日本循環器病予防学会学術総会
• [Book] 生命金属ダイナミクス 生体内における金属の挙動と制御 第8章 制御・創薬 第4節 血中微量元素濃度のICP-MS測定による標準値設定と「がんリスク」スクリーニング法 -メタロバランス検査-への応用 (2021)
  • Author(s): 岡本直幸、清水拓弥、藤本俊介、古城公佑、池田篤史、宮城洋平、三上春夫、中村洋子、永瀬浩喜
  • Total Pages: 509
  • Publisher: (株)エヌ・ティー・エス
• [Book] Clinical Neuroscience (2021)
  • Author(s): 間野 達雄, 岩田 淳
  • Total Pages: 160
  • Publisher: 中外医学社
• [Book] 顔身体学ハンドブック (2021)
  • Author(s): 小林俊輔
  • Total Pages: 442
  • Publisher: 東京大学出版会
• [Book] 月刊 細胞「疫学研究における遺伝的要因と食事要因」 (2021)
  • Author(s): 栗木清典
  • Total Pages: 80
  • Publisher: ニューサイエンス社
• [Remarks] コホート・生体試料支援プラットフォームホームページ
  • URL: http://cohort.umin.jp/
• [Remarks] 岩手医科大学 医歯薬総合研究所 西塚研究室
  • URL: http://www.nishizukalab.org/?lang=ja
• [Remarks] 福島県立医科大学生化学講座ホームページ
  • URL: https://hashimoto-lab.org/
• [Remarks] 千葉大学社会精神保健教育研究センター
  • URL: http://www.m.chiba-u.ac.jp/class/shakai/jp/byoutai/index.html
• [Remarks] 精神疾患ブレインバンク・DNAバンクホームページ
  • URL: http://www.fmu-bb.jp/
• [Remarks] 慶應義塾大学衛生学公衆生学教室ホームページ
  • URL: https://keiopublichealth.jp/research/research04.html
• [Remarks] 順天堂大学大学院 臨床腫瘍学
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/rinsho_shuyo/k4.html
• [Remarks] 慶應義塾大学医学部百寿総合研究センター公式ページ
  • URL: http://www.keio-centenarian.com/
• [Remarks] 横浜市立大学 大学院医学研究科微生物学・分子生体防御学教室ホームページ
  • URL: http://www-user.yokohama-cu.ac.jp/~saikin/
• [Remarks] 神奈川県みらい未病コホート研究ホームページ
  • URL: https://www.me-byo-cohort.jp/
• [Remarks] 浜松医科大学細胞分子解剖学講座ホームページ
  • URL: https://www.hama-med.ac.jp/mt/setou/ja/prize/
• [Remarks] 静岡県立大学食品栄養科学部栄養生命科学科 栄養サマースクール「健康の科学を体験しよう!」2021
  • URL: https://dfns.u-shizuoka-ken.ac.jp/dnls/policy14.html
• [Remarks] J-MICC STUDY
  • URL: http://www.jmicc.com
• [Remarks] 滋賀医科大学薬理学講座ホームページ
  • URL: http://www.shiga-med.ac.jp/pharm/
• [Remarks] 高島コホート研究ホームページ
  • URL: https://www.shiga-med.ac.jp/hqcera/project/takashima_study/index.html
• [Remarks] 京都大学循環器内科分子病態学研究グループホームページ
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/sentan-bunshi/
• [Remarks] 理研CBSタンパク質構造疾患研究チーム ホームページ
  • URL: http://motomasalab.riken.jp
• [Remarks] 大阪大学大学院薬学研究科 神経薬理学分野ホームページ
  • URL: http://molpharm.umin.jp/index.html
• [Remarks] 国立研究開発法人 日本医療研究開発機構プレスリリース
  • URL: https://www.amed.go.jp/news/release_20170622-01.html
• [Remarks] 愛媛大学プロテオサイエンスセンター病態生理解析部門ホームページ
  • URL: https://www.m.ehime-u.ac.jp/school/imailab
• [Remarks] 佐賀大学医学部社会医学講座予防医学分野ホームページ
  • URL: http://www.prevent.med.saga-u.ac.jp/index.html
• [Remarks] 熊本大学エイズ学研究センター佐藤研究室WEBサイト
  • URL: http://www.caids.kumamoto-u.ac.jp/satou/index.html
• [Remarks] 熊本大学ヒトレトロウイルス学共同研究センター 佐藤研究室ホームページ
  • URL: http://www.caids.kumamoto-u.ac.jp/satou/index.html
• [Patent(Industrial Property Rights)] 血清試料検査装置、及び血清試料の検査方法 (2022)
  • Inventor(s): 伊藤寛晃
  • Industrial Property Rights Holder: 伊藤寛晃
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2021-546966
  • Overseas
• [Patent(Industrial Property Rights)] KIF3モーターに基づく精神疾患の治療又は予防、及び薬物スクリーニング (2021)
  • Inventor(s): 廣川信隆, 森川桃, 吉原壮悟, 田中庸介, 武井陽介, 小川覚之, 吉川武男, 國井泰人
  • Industrial Property Rights Holder: 廣川信隆, 森川桃, 吉原壮悟, 田中庸介, 武井陽介, 小川覚之, 吉川武男, 國井泰人
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: WO/2021/100685
  • Overseas