Development of reductive dimetallation reactions

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06593
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Synthetic chemistry
• Research Institution: Hokkaido University
• Principal Investigator: DOI Ryohei 北海道大学, 薬学研究院, 助教 (40780052)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 還元的カップリング / ニッケル触媒 / アルキン

Outline of Final Research Achievements

The reductive dimetallation reaction has, unfortunately, never been realized. Instead, I have successfully developed nickel-catalyzed reductive carboxylation of ynamide with carbon dioxide. Interestingly, the regioselectivity of the carboxylation was controlled by reductant. I have already reported reductive carboxylation with zinc powder to afford dehydroamino acid at Chemical Communication. I will also prepare manuscript of reductive carboxylation using organozinc reagent. I will conduct intramolecular reaction instead of intermolecular one to achieve reductive dimetallation.

Free Research Field

有機遷移金属化学