association between activity of daily living and tau deposition in alzheimers disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06621
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Basic / Social brain science
• Research Institution: Tohoku University
• Principal Investigator: Harada Aiko (石木愛子) 東北大学, 大学病院, 助教 (30778634)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: アルツハイマー病 / 日常生活動作 / タウ / PET

Outline of Final Research Achievements

Tau accumulation in the brain correlates with the cognitive function in Alzheimer’s disease (AD). The activity of daily living (ADL) which determines the stage of dementia is also seemed to correlate with tau deposition. On order to verify the hypothesis, we performed longitudinal [18F]THK-5351 PET scan which have been developed as tau PET tracer and ADL score in AD and mild cognitive impairment patients. At baseline study, [18F]THK-5351 retention significantly correlated with the ADL score. However, the facts that [18F]THK-5351 bound to monoamine oxidase-B (MAO-B) and might have limited utility as a biomarker of tau protein were revealed in other post-mortem study . In consequence, prearranged follow up study was cancelled.

Free Research Field

老年医学