Deciphering the pathogenesis of neuropsychiatric disease using Depdc5 conditional KO mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06765
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Laboratory animal science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ishida Saeko 東京医科歯科大学, 難治疾患研究所, 助教 (50777927)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: てんかん / 自閉症

Outline of Final Research Achievements

The comorbidity between epilepsy and psychosis is well known, but the underlying common pathogenesis remains unclear. Recently, mutations of DEP　domain　containing protein 5 （DEPDC5）gene have been reported from patients with various type of epilepsies and/or psychiatric disorders including autism spectrum disorder (ASD). It suggests that understanding the function of Depdc5 provides new insights into pathogenesis of both diseases.
Depdc5 is reported as an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), a central regulator of cell growth, proliferation and protein synthesis. However, the function in brain is still unknown. Because homozygous Depdc5 knockout rodents are embryonic lethal, in this study, we conditionally deleted Depdc5 in brain of mice, and characterized their phenotypes.

Free Research Field

実験動物学