Developmental interaction between the thalamus and the cerebral cortex

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06822
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kanazawa University
• Principal Investigator: Ebisu Haruka 金沢大学, 医学系, 博士研究員 (40780226)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 視床

Outline of Final Research Achievements

We uncovered the mechanism underlying pattern formation of the mouse thalamus. Our analysis using Foxp2 (R552H) knock-in mice revealed that Foxp2 is necessary for posterior thalamic differentiation. Thalamus-specific loss-of-function studies using in utero electroporation showed that Foxp2 is important thalamus-autonomously. Injection of neuronal tracers revealed that the thalamocortical projection was also controlled by Foxp2. These results indicate that Foxp2 is an important regulator for pattern formation of the thalamus.

Free Research Field

脳神経科学