2017 Fiscal Year Final Research Report
Developmental interaction between the thalamus and the cerebral cortex
Project/Area Number |
16H06822
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | Kanazawa University |
Principal Investigator |
Ebisu Haruka 金沢大学, 医学系, 博士研究員 (40780226)
|
Project Period (FY) |
2016-08-26 – 2018-03-31
|
Keywords | 視床 |
Outline of Final Research Achievements |
We uncovered the mechanism underlying pattern formation of the mouse thalamus. Our analysis using Foxp2 (R552H) knock-in mice revealed that Foxp2 is necessary for posterior thalamic differentiation. Thalamus-specific loss-of-function studies using in utero electroporation showed that Foxp2 is important thalamus-autonomously. Injection of neuronal tracers revealed that the thalamocortical projection was also controlled by Foxp2. These results indicate that Foxp2 is an important regulator for pattern formation of the thalamus.
|
Free Research Field |
脳神経科学
|